Dual Function Research Articles

Biocompatible WSe2@BSA Dots with Merged Catalyst and Coreactant for Efficient Electrochemiluminescence.

Electrochemiluminescence (ECL) is a powerful tool for clinical diagnosis due to its exceptional sensitivity. However, the standard tripropylamine (TPrA) coreactant for Ru(bpy)3Cl2, the most widely studied and used ECL system, is highly toxic. Despite extensive research on alternative coreactants, they often fall short in poor efficiency. From a reaction kinetics perspective, accelerating electrooxidation rate of Ru(bpy)3Cl2 is an essential way to compensate the efficiency limitation of coreactants, but is rarely reported. Here, a hybrid electrocatalyst@coreactant dots for the ECL of Ru(bpy)3Cl2 is reported. The as-prepared WSe2@bovine serum albumin (WSe2@BSA) dots is biocompatible, and demonstrate dual functions, i.e., the BSA shell works as a coreactant, meanwhile, the WSe2 core effectively catalyzes Ru(bpy)3Cl2 oxidation. As a result, WSe2@BSA dots exhibit an exceptionally high efficiency comparable to TPrA for the ECL of Ru(bpy)3Cl2. In addition, the procedure for synthesizing WSe2@BSA dots is facile (room temperature, atmospheric conditions), rapid (5min), and scalable (for millions of bioassays). A biosensor utilizing WSe2@BSA dots shows promise for highly sensitive detecting glypican-3 in clinical liver cancer serum samples, especially for alpha-fetoprotein-negative patients. This work opens a new avenue for developing a highly efficient ECL system for biosensing and clinical diagnosis.

From single to multi‐purpose reservoir: A framework for optimizing reservoir efficiency

AbstractThe prevailing challenge centers on the limited application of single‐purpose flood control reservoirs transitioning to multi‐purpose reservoirs, which, despite their potential, often fall short in addressing the escalating demands for diverse water resource management. These challenges are compounded by outdated operational rules and changing environmental conditions. This research develops a framework to enhance the dual functionality of reservoirs, initially designed for flood control, to also support water supply through the determination of maximum safe water levels (MSWLs). Utilizing historical inflow data and reservoir simulation models, the study identifies opportunities for optimizing United States Army Corps of Engineers Louisville District reservoirs. It highlights certain reservoirs as ideal for augmenting water supply capabilities without compromising flood control performance. Others remain critical for flood management due to limited water supply potential, underscoring the importance of maintaining a focus on flood control. The findings illuminate the intricate balance required between managing flood risks and enhancing water supply, indicating that precise operational adjustments can significantly improve reservoir sustainability and efficiency. This method offers a viable pathway to convert single purpose reservoirs into multi‐purpose reservoirs, meeting growing water demands while ensuring robust flood mitigation, and making a step toward better water utilization.

Sonication-Assisted Self-Assembled Resveratrol Nanoparticles with Enhanced Antiviral and Anti-inflammatory Activity against Respiratory Syncytial Virus-Induced Pneumonia.

Respiratory syncytial virus (RSV)-induced viral pneumonia in children is common worldwide. Its high occurrence and lack of an effective vaccine make it a leading cause of death in children. Severe RSV infection can trigger uncontrolled inflammatory responses in patients, so the development of small molecule drugs with the dual function of "direct antivirus" and "inflammatory response regulation" is welcome. Resveratrol (Res) has been reported to have antiviral and anti-inflammatory pharmacological effects, but its application is limited because of its poor water solubility and oral bioavailability. Based on small-molecule nanotechnology, we developed a sonication-assisted self-assembly method for preparing insoluble Res into highly soluble resveratrol nanoparticles (Res NPs). The obtained Res NPs exhibited a higher water solubility and a faster dissolution rate, which was more conducive to the effectiveness of Res in addressing RSV-induced viral pneumonia. In vitro studies had shown that Res NPs played an antiviral role by inhibiting RSV replication and reducing the production of pro-inflammatory cytokines. Nebulized inhalation administration of Res NPs prolonged the drug's residence time in the lungs, which appears to increase the accumulation and effectiveness of Res NPs. Additionally, in vivo studies had demonstrated significant benefits of Res NPs in inhibiting RSV viral load and improving the pulmonary microenvironment in RSV-infected mice. Both antiviral and anti-inflammatory experiments had confirmed that the pharmacological activity of Res NPs is superior to that of Res. This suggested that nanosizing Res was an effective way to enhance the original pharmacological activity of Res and also offered a new formulation strategy for treating viral pneumonia.

A novel multiscale cGAN approach for enhanced salient object detection in single haze images

In computer vision, image dehazing is a low-level task that employs algorithms to analyze and remove haze from images, resulting in haze-free visuals. The aim of Salient Object Detection (SOD) is to locate the most visually prominent areas in images. However, most SOD techniques applied to visible images struggle in complex scenarios characterized by similarities between the foreground and background, cluttered backgrounds, adverse weather conditions, and low lighting. Identifying objects in hazy images is challenging due to the degradation of visibility caused by atmospheric conditions, leading to diminished visibility and reduced contrast. This paper introduces an innovative approach called Dehaze-SOD, a unique integrated model that addresses two vital tasks: dehazing and salient object detection. The key novelty of Dehaze-SOD lies in its dual functionality, seamlessly integrating dehazing and salient object identification into a unified framework. This is achieved using a conditional Generative Adversarial Network (cGAN) comprising two distinct subnetworks: one for image dehazing and another for salient object detection. The first module, designed with residual blocks, Dark Channel Prior (DCP), total variation, and the multiscale Retinex algorithm, processes the input hazy images. The second module employs an enhanced EfficientNet architecture with added attention mechanisms and pixel-wise refinement to further improve the dehazing process. The outputs from these subnetworks are combined to produce dehazed images, which are then fed into our proposed encoder–decoder framework for salient object detection. The cGAN is trained with two modules working together: the generator aims to produce haze-free images, whereas the discriminator distinguishes between the generated haze-free images and real haze-free images. Dehaze-SOD demonstrates superior performance compared to state-of-the-art dehazing methods in terms of color fidelity, visibility enhancement, and haze removal. The proposed method effectively produces high-quality, haze-free images from various hazy inputs and accurately detects salient objects within them. This makes Dehaze-SOD a promising tool for improving salient object detection in challenging hazy conditions. The effectiveness of our approach has been validated using benchmark evaluation metrics such as mean absolute error (MAE), peak signal-to-noise ratio (PSNR), and structural similarity index measure (SSIM).

An eco-friendly approach of preparation electric-driven thermochromic fabrics based on foam finishing

The novel strategy to endow Janus fabric with double-sided dual functions based on foam finishing was reported, which is an energy-efficient and environmentally-friendly method. The wet-state foam infiltration mechanism on the fabric surface was investigated, and the stability of the foam in solution was analysed in relation to surface tension and viscosity, as well as the loading capacity of the functional particles and the effect on fabric properties. And the controlled discoloration Janus fabric, driving by voltage, has been successfully created. The fabric shows remarkable electrothermal color-changing properties and wearability, and can be self-supplied with Joule heat to meet the demand of color change at any time: the temperature of the Janus fabric rapidly increases from room temperature to over 53.6 °C in 15 s at the applied voltage of 8 V, and the fabric temperature can be adjusted in the range of 20–62.5±3℃ at the voltage of 0–8 V. The fabric color can be transformed from blue to white within 6 s, and it can restore the color after 10 s of power off. Besides, the Janus fabric has excellent flexibility and resistance to heating fatigue, which can withstand 1000 bending cycles, and it was found that the Janus fabric has excellent temperature and color stability after 300 heating/cooling cycles and 6 hours of continuous energization. Compared to conventional finishing, the foam-finished Janus fabric not only possesses greater air permeability and handling properties, but also more energy savings. The experimental results show that the study of foam finishing is useful for expanding the application of surface science in fabric performance enhancement and provides a valuable reference for the green and smart development of textiles.

Nanocomposite Foils of PS/Cu : Dual Functionality of Optical Enhancement and Antibacterial Activity on Aeromonas hydrophila

Nanocomposite Foils of PS/Cu : Dual Functionality of Optical Enhancement and Antibacterial Activity on Aeromonas hydrophila

Integrating machine learning and parametric design for energy-efficient building cladding systems in arid climates: Sport hall in Kerman

Climate change, driven by fossil fuel dependence, presents a significant challenge for the construction industry, particularly in energy-intensive regions like arid climates. This research investigates the potential of integrating machine learning and parametric optimization to enhance the energy efficiency of spatial structure domes in such environments. Focusing on a sports pavilion in Kerman, Iran, the study examines the crucial role of cladding systems in building energy performance. Employing a rigorous four-phase methodology, the research optimizes dome cladding materials for hot, dry climates using a dual objective function: energy cost and material cost. The process involves a comprehensive literature review, data-driven material selection, advanced energy simulations, and optimization analysis. Parametric modeling tools (Rhino, Grasshopper, Honeybee) facilitate the comparative analysis of various cladding systems. Multivariate Polynomial Regression (MPR) enables predictive modeling of energy consumption and material costs, streamlining the design process for architects. The optimized solution is a hybrid cladding model composed of 10 % polycarbonate and 90 % aluminum. Analysis reveals that the hybrid system offers superior energy optimization compared to pure aluminum (4.58 %) and polycarbonate (5.70 %). While polycarbonate has a lower initial material cost, the hybrid system achieves a balance between material expenditure and long-term energy efficiency. This highlights the importance of considering life-cycle costs when evaluating building envelope materials. This research advances a framework that leverages machine learning and parametric design for building envelope optimization. This framework empowers architects and engineers to create energy-efficient structures within arid environments, promoting a more sustainable built environment.

Symmetric engineered central cross-shaped broadband metamaterial absorber with high absorption and stability for solar sailing and solar energy applications

We propose a theoretical design and analysis of a broadband metamaterial absorber (MMA) with significant potential for solar sailing applications which is a method of spacecraft propulsion that usages the momentum of sunlight to propel a spacecraft through space. The absorber features a metal-dielectric-metal configuration with a tungsten (W) based resonator and ground plane, and a Silicon-dioxide (SiO₂) substrate. Addressing the critical need for materials that can efficiently harness solar radiation for propulsion in space, our design achieves an average absorption of 99.15 % over a broad spectrum from 250 nm to 1200 nm, covering the UV–Visible–NIR regions, with near-unity absorption peaks at 362 nm and 915.8 nm. It maintains high absorptions of 84.9 % and 86 % under transvers electric and transvers magnetic modes respectively, demonstrating excellent wide incident angle stability and polarization insensitivity due to its symmetric design. PCR values close to zero confirm its functionality as an absorber rather than a polarizer. The MMA shows minimal deformation across temperatures from 500 K to 1750 K and remains stable under various mechanical stresses, proving its durability and efficiency in space. Additionally, in solar thermophotovoltaic (STPV) systems, the MMA demonstrates high photothermal conversion efficiency (PTCE) over a wide temperature range (500 °C to 1500 °C) and different concentration factors. This dual functionality highlights its potential for both efficient space exploration and terrestrial solar energy harvesting, making it a versatile tool for future technological applications.

A two-in-one molybdenum disulfide-chitosan nanoparticles system for activating plant defense mechanisms and reactive oxygen species to treat Citrus Huanglongbing

Citrus Huanglongbing (HLB) poses an enormous challenge to Citrus cultivation worldwide, necessitating groundbreaking interventions beyond conventional pharmaceutical methods. In this study, we propose molybdenum disulfide-chitosan nanoparticles (MoS2-CS NPs) through electrostatic adsorption, preserving the plant-beneficial properties of molybdenum disulfide (MoS2), while enhancing its antibacterial effectiveness through chitosan modification. MoS2-CS NPs exhibited significant antibacterial efficacy against RM1021, and the closest relatives to Candidatus Liberibacter asiaticus (CLas), Erwinia carotovora, and Xanthomonas citri achieved survival rates of 7.40 % ± 1.74 %, 8.94 % ± 1.40 %, and 6.41 % ± 0.56 %, respectively. In vivo results showed, CLas survival rate of 10.42 % ± 3.51 %. Furthermore, treatment with MoS2-CS NPs resulted in an increase in chlorophyll and carotenoid content. Concomitantly, a significant reduction in malondialdehyde (MDA), soluble sugar, hydrogen peroxide (H2O2), and starch contents was also observed. Mechanistically, MoS2-CS NPs enhanced the activity of antioxidant-related enzymes by upregulating the expression of antioxidant genes, thereby galvanizing the antioxidant system to alleviate oxidative stress. Collectively, this dual functionality—combining direct antibacterial action with the activation of plant defense mechanisms—marks a promising strategy for managing Citrus Huanglongbing and suggests potential agricultural applications for MoS2-based antibacterial treatments.

Carbonaceous Shape-Stabilized Octadecane/Multi-Walled Carbon Nanotube Composite Materials for Enhanced Energy Storage and Electromagnetic Interference Shielding.

Developing materials for efficient energy storage and effective electromagnetic interference (EMI) shielding is crucial in modern technology. This study explores the synthesis and characterization of carbonaceous shape-stabilized octadecane/MWCNT (multi-walled carbon nanotube) composites, utilizing activated carbon, expanded graphite or ceramic carbon foam, as shape stabilizers for phase change materials (PCMs) to enhance thermal energy storage and EMI shielding, for energy-efficient and advanced applications. The integration of octadecane, a phase change material (PCM) with carbonaceous stabilizers ensures the material's stability during phase transitions, while MWCNTs contribute to improved thermal storage properties and EMI shielding capabilities. The research aims to develop novel composites with dual functionality for thermal storage and EMI shielding, emphasizing the role of carbon matrices and their MWCNT composites. SEM and CT microtomography analyses reveal variations in MWCNT incorporation across the matrices, influenced by surface properties and porosity. Leaching tests, infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) confirm the composite's stability and high latent heat storage. The presence of nanotubes enhances the thermal properties of octadecane and ΔH values almost reached their theoretical values. EMI shielding effectiveness measurements indicate that the composites show improved electric properties in the presence of MWCNTs.

Hydroxylamine‐O‐Sulfonic Acid (HOSA): A Recent Synthetic Overview

AbstractHydroxylamine‐O‐sulfonic acid has been used as a versatile nitrogen source in synthetic organic chemistry. It has dual function and utilized both as a nucleophile and an electrophile during different synthetic transformations. This reagent is stable and easy to handle in both aqueous and organic solvents. It can be used with different functional groups under mild reaction conditions, making its widely applicable for constructing complex molecules. It has been utilized for various applications such as agrochemicals, pharmaceuticals, and polymer industries in the formation of S−N, C−N, O−N, and N−N bonds, as well as for efficient cyclization reactions under metal‐free conditions with excellent stereo– and regioselectivity. The present review provides a brief overview of all the advancements made in the past two decades using hydroxylamine‐O‐sulfonic acid as a nitrogen source.

Conductively coupled terahertz metamaterials with dual functions of electromagnetically induced transparent and Fano effects for sensing applications

A terahertz metamaterial structure consisting of two U-shaped split-ring resonators and a horizontal cut-line resonator is designed for realizing the electromagnetically induced transparency (EIT) effect and the Fano resonance effect. The genesis of the EIT and Fano resonance bifunctionality is illustrated by combining the near-field distribution analysis of transparent windows and transmission dips. Interestingly, the bifunctional dual-band transparency effect could transform into a single-functional single-band transparency effect when we change the position of the square metal sheet in the vertical direction of the composited terahertz metamaterial structure. In addition, based on the high-quality factor of Fano resonance response, the proposed bifunctional terahertz metamaterial device has good refractive index sensing sensitivity. These results indicate that our proposed terahertz metamaterial can provide guidance for the design of subsequent multifunctional and integrated metamaterials and optoelectronic devices.

Annulative Coupling of β‐Ketosulfoxonium Ylides and β‐Ketothioamides: Access to Thiazolines and Thiazolidin‐4‐Ones

AbstractA catalyst‐ and additive‐free one‐step protocol for synthesizing thiazolines and thiazolidin‐4‐ones, utilizing the annulative coupling between β‐ketosulfoxonium ylides and β‐ketothioamides has been described. The dual functionalization of β‐ketosulfoxonium ylides through S‐alkylation and intramolecular N‐cyclization leads to the generation of both C−S and C−N bonds. The developed synthetic methods facilitate the synthesis of diverse functionalized thiazolines and thiazolidin‐4‐one derivatives, validated through large‐scale reactions.

Hydrophobically associated amphiphilic copolymer fracturing fluid with dual Functions of fracturing and flooding for enhanced oil recovery

Polymer fracturing fluids are widely used in oil and gas extraction; however, the residues left after gel breaking can easily clog fractures, leading to formation damage and a decline in economic benefits. To address this issue, this study developed a new type of hydrophobic associative amphiphilic copolymer, P(AM-AA-AAEOn), prepared through the copolymerization of fatty alcohol polyoxyethylene ether (AAEOn), acrylic acid, and acrylamide. The properties of the system, including shear resistance and thixotropy, shear recovery, viscoelasticity, salt responsiveness, and interfacial tension, were thoroughly investigated by measuring its hydrodynamic size, molecular weight, root-mean-square radius of gyration, and second virial coefficient. Experimental results demonstrated that with a monomer ratio of 300:100:1, this fracturing fluid system exhibited excellent shear resistance, viscoelasticity, effective sand carrying, and corrosion inhibition, along with good gel-breaking and compatibility properties. Further oil displacement tests revealed that P(AM-AA-AAEOn), due to its superior interfacial activity and wettability, significantly enhanced oil recovery efficiency by 25.01%. These characteristics not only resolved the issue of flowback in traditional polymer fracturing fluids but also facilitated the efficient integration of fracturing and oil displacement. The innovation of this research lies in the development of a novel, efficient, and environmentally friendly fracturing fluid, which provides significant theoretical and practical foundations for oilfield fracturing technology and holds promising industrial application prospects.

Ruthenium-Catalyzed Interrupted Transfer Hydrogenation: An Approach for Reductive Functionalization of Quinolinium and Napthyridinium Salts.

Until now, a myriad of effective approaches have emerged for the functionalization of N-heteroaryl C-H bonds. In contrast, dearomatization and construction of fused heterocycles from activated heteroarenes is still a subject to explore. In this work, we present a refined approach for both dearomatization of N-heteroarenes and the synthesis of fused heterocycles from activated heteroarenes ruthenium catalysis using paraformaldehyde along with additive and base. Notably, quinolinium salts with a hydrogen at the C-4 position yield a methoxymethyl-substituted fused cyclic product through the Thorpe Ingold effect. An innovative aspect of this research is the dual functionality of paraformaldehyde as both a hydride donor and electrophile, utilizing readily available feedstock chemicals. A broad range of electron withdrawing and donating substituents was tolerable under standardized reaction conditions.

Hollow mesoporous Prussian blue nanoenzymes as Rapamycin carrier for targeted treatment of ischemia/reperfusion-induced acute kidney injury through pro-mitophagy and oxidative stress alleviation

The kidney’s abundant mitochondrial content and substantial oxygen requirements make it particularly vulnerable to a series of detrimental events following ischemia/reperfusion (I/R). These events encompass oxidative stress, mitochondrial impairment, depletion of adenosine triphosphate (ATP), and inflammation, cumulatively leading to acute kidney injury (AKI). Currently, no approved therapy beyond supportive care is available for AKI. While numerous studies have focused on neutralizing pre-existing reactive oxygen species (ROS) to mitigate AKI, insufficient attention has been paid to addressing the root causes of ROS. Here, we prepared Rapamycin (Rapa)-loaded hollow mesoporous Prussian blue nanoparticles (HMPB-Rapa) and grafted injured renal-targeted hyaluronic acid (HA) onto HMPB-Rapa (HA-HMPB-Rapa), which effectively scavenge pre-existing ROS and the source (massive damaged mitochondria) through the dual function of HMPB carrier and Rapa, thus preventing the further burst of ROS. In the I/R-induced AKI rat model, a single-dose of HA-HMPB-Rapa 6 h after I/R injury effectively inhibited oxidative stress and inflammation, protected renal cells from apoptotic damage, as well as ultimately restored renal function, and attenuated pathological changes. Mechanistically, HA-HMPB-Rapa cleared damaged mitochondria by activating the pro-mitophagy signaling pathway (PINK-1/Parkin-P62-LC3), cutting off the conduction in the intrinsic apoptotic pathway mediated by the Bax-Cyt-c-Cleaved Casp-3 signaling axis, and reduced the expression of renal tubular marker kidney injury molecule-1. HA-HMPB-Rapa represents an exciting new avenue for the treatment of diseases related to I/R-induced injury.

Developing Advanced Antibacterial Alginic Acid Biomaterials through Dual Functionalization.

This paper delves into the intersection of biomaterials and antibacterial agents, highlighting the importance of alginic acid-based biomaterials. We investigate enhancing antibacterial properties by functionalizing alginic acid with an ionic liquid and a potent chelating agent, tris(hydroxypyridinone) (THP). Initial functionalization with the ionic liquid markedly improves the material's antibacterial efficacy. Subsequent functionalization with THP further enhances this activity, reducing the minimum inhibitory concentration from 6 to 3 mg/mL. Notably, the newly developed dual-functionalized materials exhibit no cytotoxic effects at the concentrations tested, underscoring their potential for safe and effective antibacterial applications. These findings highlight the promising role of dual-functionalized alginic acid biomaterials in developing advanced antibacterial treatments.

Cyclic Acetals as Expanding Monomers to Reduce Shrinkage.

Polarity-reversal catalysts (PRCs) for hydrogen-atom transfer reactions have been known in radical chemistry for more than 60 years but are rarely described and utilized in the field of photopolymerization up to now. Herein, we present the use of thiols in a unique dual function as thiol-ene click reagents and as polarity-reversal catalyst (PRC) for the radical-mediated redox rearrangements of benzylidene acetals. During the rearrangement reaction, cyclic benzylidene acetals are transformed into benzoate esters leading to a significant volumetric expansion to reduce thermoset shrinkage. We were able to show that this expansion on a molecular level reduces shrinkage and polymerization stress but does not significantly affect the (thermo-)mechanical properties of the cross-linked networks. One of the key advantages of this process lies in its simplicity. No additives like sensitizers or combinations of different initiators (radical and cationic) are needed. Furthermore, the same light source can be used for both the polymerization reaction and expansion through rearrangement. Additionally, the applied photoinitiator enables spatial and temporal control of the polymerization; thus, the developed system can be an excellent platform for additive manufacturing processes.

Rare earth oxide promoted Ru/Al2O3 dual function materials for CO2 capture and methanation: An operando DRIFTS and TGA study

Dual-function materials (DFMs) combine sorbent and catalytic components to perform selective CO2 capture and subsequent hydrogenation. This study explores the performance of rare-earth oxides (REOs) as CO2 adsorption sites on Ru/Al2O3. REOs increase CO2 uptake by upwards of +60 % by enhancing the overall catalyst surface basicity and favoring metal–support interactions. Thermogravimetric analysis during CO2 adsorption-hydrogenation cycles exhibited significant catalytic activity and enhanced stability of Ru-REO/Al2O3 at temperatures as low as 200 °C. This leads to methane production of 50–85 µmol g−1, surpassing recently reported values obtained for alkali and alkali-earth promoted Ru-based materials operated at 250 °C. The highest performing studied DFM, RuNd2O3/Al2O3, achieved 85 % CO2 capture efficiency and steadily produced methane in cyclic operation (+120 % CO2 uptake relative to Ru/Al2O3). Operando DRIFTS revealed that the dominant mechanism for methane formation is the hydrogenation of ruthenium carbonyls, which are stabilized by REOs. Upon CO2 exposure, surface carbonates and bicarbonate species form more abundantly on DFMs than on Ru/Al2O3. This confirms that REOs enhance the adsorption and retention of carbonates, which generate additional promoter-related reaction pathways during low-temperature hydrogenation. These findings are crucial in the advancement of sustainable, wider operation range carbon capture and utilization technologies.

Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst

Electrochemical methods with tissue-implantable microelectrodes provide an excellent platform for real-time monitoring the neurochemical dynamics in vivo due to their superior spatiotemporal resolution and high selectivity and sensitivity. Nevertheless, electrode implantation inevitably damages the brain tissue, upregulates reactive oxygen species level, and triggers neuroinflammatory response, resulting in unreliable quantification of neurochemical events. Herein, we report a multifunctional sensing platform for inflammation-free in vivo analysis with atomic-level engineered Fe single-atom catalyst that functions as both single-atom nanozyme with antioxidative activity and electrode material for dopamine oxidation. Through high-temperature pyrolysis and catalytic performance screening, we fabricate a series of Fe single-atom nanozymes with different coordination configurations and find that the Fe single-atom nanozyme with FeN4 exhibits the highest activity toward mimicking catalase and superoxide dismutase as well as eliminating hydroxyl radical, while also featuring high electrode reactivity toward dopamine oxidation. These dual functions endow the single-atom nanozyme-based sensor with anti-inflammatory capabilities, enabling accurate dopamine sensing in living male rat brain. This study provides an avenue for designing inflammation-free electrochemical sensing platforms with atomic-precision engineered single-atom catalysts.