In this paper, the sampling and reconstruction problems in function subspaces of Lp(Rn) associated with the multi-dimensional special affine Fourier transform (SAFT) are discussed. First, we give the definition of the multi-dimensional SAFT and study its properties including the Parseval’s relation, the canonical convolution theorems and the chirp-modulation periodicity. Then, a kind of function spaces are defined by the canonical convolution in the multi-dimensional SAFT domain, the existence and the properties of the dual basis functions are demonstrated, and the Lp-stability of the basis functions is established. Finally, based on the nonuniform samples taken on a dense set, we propose an iterative reconstruction algorithm with exponential convergence to recover the signals in a Lp-subspace associated with the multi-dimensional SAFT, and the validity of the algorithm is demonstrated via simulations.