The effect of various factors on rate of drying of wheat (below the critical moisture content) has been studied at temperatures in the range 12°-45° c., and under absolute pressures in the range 0.5–8 cm. of mercury. The results imply that the rate of diffusion of moisture within individual grains remains the factor governing rate of drying in vacuo in the manner known for air-drying in the falling-rate period, and that the rate of change of the diffusion coefficient with temperature (over the range 12° 46° c.) is the same as that of the vapour pressure of water. Within the range 13–30% moisture content (dry-weight basis), the rate of drying in vacuo is directly proportional to the free water content, but the term ‘free’ means the difference, not between total and equilibrium moisture contents as in air-drying, but between total and firmly held or bound water, the level of which must depend upon temperature: at 30°-40° c. it is about 9–10% (dry-weight basis). However, with wheats of similar total moisture content, the rate of drying is greater if the concentration of moisture in the outer layers is higher than that in the interior of individual grains, as in freshly wetted wheat. Variation in pressure affects directly only the rate of removal of vapour which has already left the solid, but this in turn affects the rate of drying. The effect depends on impedance to vapour movement caused by form of apparatus and disposition of the material, and can be substantially counteracted by admission of a small sweeping current of air, the optimum proportion of which is equimolecular with respect to the evaporated water.