Browning and a serious drop in anthocyanin level occur during microwave-assisted spouted bed drying (MWSB) of purple-flesh sweet potato (PFSP) cubes. Blanching pretreatment inhibits browning and also affects the drying behavior. Effects of microwave blanching (MWB), hot water blanching (HWB), and steam blanching (SB) were examined experimentally. The results showed that MWB leads to rapid peroxidase (POD) degradation, reduces the drying time, and yields highest anthocyanin level after MWSB drying. However, the color of the dried product was not as bright and purple as those obtained by HWB and SB treatments. Microwave blanching can improve the MWSB drying process to maintain the anthocyanin level in dried products while reducing the drying time.