In the Kharif grain sorghum growing areas of Karnataka, the sorghum production suffers greatly due to weed problem, which offers limitations to crop. It was found that weed infestation become unmanageable throughout the growing period by the traditional methods of interculturing and manual weeding due to continuous and heavy rains during entire vegetative and early reproductive stages of Kharif sorghum. Hence, integration of herbicides with some cultural operations and use of pre-emergence, post-emergence herbicides in combination with mechanical methods can prove to be more successful. A field experiment entitled “Weed management in kharif grain sorghum” was conducted during Kharif 2019 at ARS, Hagari in deep black soil with neutral reaction (pH 7.50), organic carbon (5.5 g kg-1), available nitrogen (248.00 kg ha-1), available phosphorus (36.75 kg ha-1) and available potassium (312.00 kg ha-1). An experiment was laid out in Randomized Complete Block Design (RCBD) with three replications. There were fourteen treatments comprising of weed management practices. The dominant weeds observed in the experimental fields were among grasses Brachiaria reptans, while in broad leaved weeds, Amaranthus viridis and among sedges, Cyperus rotundus. Significantly lower population of grasses, sedges, and broad leaved weeds, weed dry weight, weed index (%) and higher weed control efficiency throughout the crop growth period was noticed in sequential pre-emergence application of atrazine 50 WP @ 0.50 kg a.i. ha-1 as PE fb 2,4-D Na Salt 80 WP @ 0.75 kg a.i. ha-1 as PoE at 25 DAS except weed free treatment. Atrazine 50 WP @ 0.50 kg a.i. ha-1 as PE fb 2,4-D Na Salt 80 WP @ 0.75 kg a.i. ha-1 as PoE at 25 DAS recorded significantly higher plant height, dry matter accumulation, leaf area, test weight, grain yield, straw yield, harvest index, gross return, net return and benefit cost ratio (160.8 cm, 183.4 gplant-1, 24.1 dm2 plant-1, 30.53 g, 4195 kg ha-1, 9891 kg ha-1, 29.80 %, Rs. 1,03,675ha-1, Rs. 71,636 ha-1and 3.24, respectively) except weed free and it was on par with atrazine 50 WP @ 0.50 kg a.i. ha-1 as PE fb IC at 25 DAS and HW at 25 DAS and IC at 40 DAS.