Supplying of the pharmaceutical industry with medicinal raw materials is carried out mainly due to it cultivation on an industrial scale. For three years (2020–2022), in the conditions of the Krasnodar region in the fields of the North Caucasian branch of VILAR there were studied the ways of hormonal regulation of the formation of seed productivity of essential oil crops – two varieties of Matricaria chamomilla and Salvia officinalis. The results of the conducted research showed that the treatment of plants in the budding phase with growth regulators Zircon (0.04 l/ha) and Gibbersib (0.03 kg/ha) led to a more friend-ly flowering of plants and, accordingly, to an increase in the yield of Matricaria seeds by 15–28 % and Sal-via by 20–28 %. At the same time, their quality im-proves – the weight of 1000 seeds increase by 6–14 %. The use of these growth regulators contributes to increasing the resistance of the studied medicinal crops to dry weather conditions and ensures a reduction in seed yield losses up to 12–26 %, while in the control it was till 22–33 %. With the complex application of Lignohumat (0.05 l/ha) in the initial growth phases of the abovementioned crops and growth regulators (Zircon and Gibbersib) in the budding phase, an increase in seed yield is observed, both in comparison with the control and with some regulators. The highest efficiency was noted in the Lignohumat + Zircon variant, where the seed yield exceeded the control by 28–39 % and in the variant with Zircon – by 9–13 %.