Use Of Drugs In Disease Research Articles

Theoretical And Methodological Foundations Construction and Application of The Model Study of Endothelioprotective Properties of Drugs Used to Treat Coronavirus Infection Covid-19

So far, with COVID-19 initiated bythe SARS-CoV-2 coronavirus, clinical practice has not introduced a method and appropriate treatment practice, either aimed at the cause of the disease or disorder, or the elimination of the main link in the pathogenesis, which would prove its effectiveness and safety. Clinical studies that are currently being conducted around the world mainly include the use of drugs for diseases in COVID-19.

Adherence to prescribed drug therapy among adult patients of General Out-Patient Department of a Tertiary Hospital in Nigeria

Objective : The widespread problems of adherence to medication denied substantial number of patients the maximum benefits of medical treatment, resulting in poor health outcomes, lower quality of life and increased health care costs. The objective of this study was to determine the extent of drug adherence among patients seen in a tertiary hospital in Nigeria. Methods : The study was a descriptive cross-sectional survey carried out among 381 patients attending the General Out-Patient Department (GOPD) of a Teaching Hospital in Nigeria. Interviewer administered questionnaire was used as the research tool and case notes of the patients were used to obtain information on drug adherence. Results : About half of the patients 194 (50.9%) adhered fully with doctor's prescription on the use of drugs for diseases they presented to the hospital. More than three quarters (78.0%) of patients aged 56 years and above adhered fully with prescription compared with 11.1% in the age group 15-25 years. The older patients had better adherence to medication than the younger patients with a statistically significant difference (p = 0.001). Many of the patients with no formal education (69.0%) adhered fully with prescription compared with 28.6% with post secondary education p = 0.001. Conclusion : Health education intervention and active role of health care providers in patients'-provider communication towards addressing the determinants of non-adherence will play a major role in improving adherence to medication. Key words: Drug, adherence, Teaching, Hospital, Nigeria

Pharmaceutically active compounds in water, Aksaray, Turkey

Pharmaceutically active compounds (PACs) are widely used around the world to maintain human and animal health. There is growing concern that these compounds pass through sewage‐treatment plants and enter the environment for potential harmful effects on living things. In this study, the occurrence of nine PACs (acetaminophen, caffeine, carbamazepine, codeine, methyltestosterone, metoprolol, propranolol, stanozolol, and testosterone) in hospital wastewater, sewage wastewater, raw water used for drinking water, and treated water was studied in three sampling events representing different flow conditions, i.e., December, April, and June 2010–2011. Most of the target compounds were detected in both hospital and sewage wastewater samples rather than in drinking water samples. The most frequently detected compounds in the samples were acetaminophen and caffeine with increased concentrations of up to 160 µg/L in sewage wastewater, while their concentrations were significantly lower in raw water. Generally, a seasonal variation of the test compounds in the samples was significant. All drugs were detected in higher levels during winter as drug use for diseases might increase through this season and a faster degradation and removal might occur during summer. The results showed that water had been polluted with these substances, and although purified by water treatment, reached humans via drinking water.

The Use of Drugs in Disease

The Use of Drugs in Disease

THE EMPLOYMENT OF DIGITALIS AND ACONITE IN THE TREATMENT OF CARDIAC DISEASE.

Among all the difficulties which have beset the subject of the proper use of drugs in disease, and there have been many, as we all know, it can not be doubted that the factor of greatest importance has been the employment of remedies by physicians without their having a correct conception, and sometimes no conception at all, of the pathological process underlying the condition which is to be relieved. This depends on the fact that many practitioners lack preliminary training, not only in morbid anatomy and morbid physiology or pathology, but also fail to study the possible effect of well-known drugs in abnormal states. The employment of certain remedies in disease has cast discredit on therapeutics by their abuse, while many physicians who have carefully studied diseased organs become so saturated, so to speak, with the seriousness of the lesions which they find that they scoff at the thought that