Drug Treatment Compliance Research Articles

Application of Alfalfa App in the management of oral anticoagulation in patients with atrial fibrillation: a multicenter randomized controlled trial

BackgroundIn recent years, mobile medical technology has made great progress in chronic disease management, but its application in patients with atrial fibrillation (AF) still needs to be clarified.ObjectiveThis study aims to determine whether the newly developed smartphone app for patients with AF (Alfalfa App) can improve anticoagulation knowledge, drug treatment compliance, and satisfaction of AF patients.MethodsAlfalfa App integrates the functions of patient education, remote consultation, and medication reminder through a simple user interface. From June 2020 to December 2020, patients with AF were recruited in five large tertiary hospitals in China. Patients were randomly divided into the Alfalfa App or routine nursing groups. Patients’ knowledge, medication adherence, and satisfaction with anticoagulation were assessed using validated questionnaires at baseline, 1 month, and 3 months.ResultsIn this randomized controlled trial, 113 patients with AF were included, 57 patients were randomly assigned to the Alfalfa App group, and 56 patients were randomly assigned to the routine nursing group. Forty-eight patients in the Alfalfa App group completed a three-month follow-up, and 48 patients in the routine nursing group completed a three-month follow-up. Basic demographic data were comparable between the two groups. The average age of AF patients was 61.65 ± 11.01 years old, and 61.5% of them were male. With time (baseline to 3 months), the knowledge scores of the Alfalfa App group (P<.001) and the routine nursing group (P = .002) were significantly improved, the compliance scores of the routine nursing group(P<.001) and Alfalfa App group(P<.001) significantly improved. Compared with the routine nursing group, patients’ knowledge level and medication compliance using the Alfalfa App at 1 month and 3 months were significantly higher (all P < .05). There were significant differences in knowledge and compliance scores between the two groups with time (all P < .05). The satisfaction degree of drug treatment in the Alfalfa App group was significantly better than that in the routine nursing group (all P < .05).ConclusionsAlfalfa App significantly improved the anticoagulation knowledge, drug treatment compliance, and satisfaction of AF patients. In oral anticoagulation management for AF patients, mobile medical technology that integrates the functions of patient education, remote consultation, and medication reminder may be helpful.Trial registrationRegistration number, ChiCTR1900024455. Registered on July 12, 2019.

LYMPHATIC FILARIASIS DRUG TREATMENT POLICIES IN EASTERN INDONESIA: WHAT TARGET CHARACTERISTICS MATTER?

Background: Lymphatic filariasis (LF) drug treatment compliance remains a challenge in Eastern Indonesia. Aims: The study sought to determine which aspects of Eastern Indonesia's LF drug treatment compliance policies were most pertinent. Methods: The 2018 Indonesian Basic Health Survey data was employed. The analysis units were adults (≥ 15 years) who had received LF drug treatment. LF drug treatment compliance was analyzed based on respondent characteristics (age, gender, marital status, education, occupation, wealth and comorbidities) using binary logistic regression. Results: The proportion of adherence to LF treatment in Eastern Indonesia was 73.1%. Respondent characteristics that influenced LF treatment compliance were age group &gt; 24 (aOR = 1.374, 95% CI: 1.305-1.447), female (aOR = 1.307, 95% CI: 1.263-1.353), all educated respondent status (aOR = 2.152, 95% CI: 2.043-2.268), and all employed respondents (aOR = 1.437, 95% CI: 1.365 - 1.512). Married respondents and those with all levels of wealth status were less likely to take LF drug treatment. Conclusion: Policy focus on improving LF treatment compliance among the younger male, the less educated, the unemployed, and those with lower social economic status. Keywords: compliance, Eastern Indonesia, lymphatic filariasis, public health

Brain Re-Irradiation Or Chemotherapy: a phase II randomised trial of re-irradiation and chemotherapy in patients with recurrent glioblastoma (BRIOChe) – protocol for a multi-centre open-label randomised trial

IntroductionGlioblastoma (GBM) is the most common adult primary malignant brain tumour. The condition is incurable and, despite aggressive treatment at first presentation, almost all tumours recur after a median of...

The effect of intensive family-centered health education on the awareness rate, diagnosis, and treatment of post-stroke depression in community families

ObjectiveTo investigate the effects of intensive family-centered health education on the awareness rate, diagnosis, and treatment of post-stroke depression (PSD) in community families.MethodsElderly patients (60–90 years) from 20 community service centers affiliated with the Department of Neurology and the Medical Association of Tongling Municipal Hospital who had been diagnosed with stroke between January 2017 and June 2020 were screened using the hospital and community electronic medical record system. In this randomized cluster trial, 119 patients from 10 communities were assigned as the control group and received routine community treatment, while 126 patients from the other 10 communities were assigned as the experimental group and received routine treatment plus family-centered intensive health education. After 12 months of medical intervention, the assessment of PSD in the two groups was performed by a neurologist and a psychiatrist, both blind to the study design, using the Hamilton Rating Scale for Depression.ResultsThe awareness rates of the causes, clinical manifestations, treatment plan, and family care of PSD in the experimental group were 88.89, 91.30, 93.65, and 92.06%, respectively. In the control group, the awareness rates of these parameters were 72.27, 69.75, 71.43, and 65.55%, respectively, and the differences between the two groups were statistically significant (P < 0.05). In the experimental group, the rates of PSD diagnosis, prompt medical attendance, drug treatment compliance, and psychotherapeutic treatment compliance were 27.78, 22.22, 18.25, and 11.90%, respectively. In the control group, the rates of these parameters were 13.79, 6.03, 3.48, and 1.72%, respectively, and the differences between the two groups were statistically significant (P < 0.05).ConclusionIntensive family-centered health education can improve the level of knowledge of PSD in the community, promote the timely treatment and diagnosis of PSD in patients, and improve the compliance rates of drug therapy and psychotherapy, so this is worthy of promotion.

A Qualitative Study of Drug Treatment Conformity Behavior among Young Drug Users Who Are in Recovery in China.

In response to social concerns about young drug users, this study aimed to qualitatively explore the types of drug treatment conformity behaviors and the processes of behavior formation among this population. Twenty-one young drug users were selected through purposive sampling, in-depth interviews were conducted using a semi-structured approach, and the data were then analyzed. The social conformity theory is used as the framework of the analysis, and the results indicate that drug treatment behaviors can be differentiated by the three types of motivation that produce conformity with drug treatment: the cognitive, affective, and utilitarian. These three types of motivations produce three types of conformity, respectively: drug treatment abidance, drug treatment compliance, and drug treatment obedience. They are affected by informational social influences, normative influences of significant others, and normative structural levels, respectively. We also propose a model of the information processing involved in drug treatment conformity. Based on an in-depth analysis of the characteristics and formation processes of the three different types of conformity, intervention strategies are proposed. This study has important guiding significance for helping young drug users maintain their drug rehabilitation ethics and successfully return to society.

Stem Cells Treatment for Wilson Disease.

Wilson Disease (WD) is a copper excretion disorder, mainly caused by mutations in the ATP7B gene. Pharmacological therapies and liver transplantation are currently the main treatment methods for WD, but they face problems such as drug treatment compliance, adverse reactions, and shortage of liver donors. Stem cell therapy of WD may correct abnormal copper metabolism permanently, which is the focus of current research. In this review, we summarized the latest research on stem cells treatment for WD, as well as current challenges and future expectations.

Analysis of Factors Related to Drug Treatment Compliance and Nursing Prevention Strategies in Patients with Diabetes Mellitus

Analysis of Factors Related to Drug Treatment Compliance and Nursing Prevention Strategies in Patients with Diabetes Mellitus

A Meta-Analysis of Influencing Factors of Drug Therapy Compliance in Chinese Children with Bronchial Asthma

We systematically attempt to evaluate the influencing factors of drug treatment compliance in childhood asthma and to provide evidence for improving patient’s treatment compliance and improving treatment success rate. The Chinese literatures that met the inclusion and exclusion criteria, such as Wanfang Medical Database, China National Knowledge Infrastructure, VIP Chinese Science and Technology Periodical Database and Chinese Biomedical Database were systematically searched. Two researchers screened the literature, conducted strict quality evaluation, extracted data from literatures that met the quality standards and used RevMan5.3 statistical software to make forest charts for outcome indicators and analyze effects. A total of 13 literatures were included. Meta-analysis results showed that lack of asthma knowledge, bad psychology and parent’s trust in medical staff had no statistically significant effects on children’s treatment compliance, while the degree of illness had a statistically significant impact on compliance (p<0.1), the pooled odds ratio and 95 % confidence interval was 0.31 (0.22-0.43). The severity of illness is the main factor for drug treatment compliance in childhood asthma.

Treatment Pattern of Antiepileptic Drugs in Pediatric with Epilepsy

Studying drug utilization helps to develop twin concepts for therapeutic formulation and essential drug lists. The main preference of using Antiepileptic drug (AED) therapy is that patients can be seizure-free for their lifetime. Treating children with epilepsy remains a major challenge, despite having several AEDs. Hence, we aimed to study drug utilization patterns among pediatric patients with epilepsy. This prospective study was conducted on 150 patients lesser than 18 years of age, receiving antiepileptic drugs. A specially designed case record form was used to collect the data on socioeconomic status, disease data, and treatment details. The majority of the children were females (60.6%), ages ranged from day 1 to 4 years (56.6%). About 35.33% were skilled laborers followed by 32.23% semi-skilled. Around 49.3% of patients belonged to the lower-middle-class family and 41.33% were diagnosed to have generalized tonic-clonic seizures (GTCS). The majority of the children were on monotherapy (81.33%) while 18.66% were on dual therapy or polytherapy. Regarding the usage of antiepileptic drugs, we found that 70.66% of children were on older AEDs like sodium valproate (27.33%) followed by clobazam (31.33%). Levetiracetam was the only new antiepileptic drug that was prescribed in 10% of patients. Monotherapy is considered as best modality, due to its low cost, safety profile, and lesser drug interactions. It can also improve drug treatment compliance and adherence. Along with older AEDs, there has been an increase in the utilization of newer AEDs, which help to broaden the therapeutic option towards the management of childhood epilepsy with a better safety profile.

Comparative efficacy and safety of interventions for treating head lice: a protocol for systematic review and network meta-analysis

BackgroundHead lice infestation is a major public health problem around the globe. Its treatment is challenging due to product failures resulting from rapidly emerging resistance to existing treatments, incorrect treatment...

Spiritual Well-Being and Its Association with Coronary Artery Disease.

Cardiovascular diseases are the main cause of mortality in the world, generating important socioeconomic and cultural impacts. Spirituality has been associated with the main risk factors for acute myocardial infarction, influencing lifestyle, and drug treatment compliance. Estimate the level of spiritual well-being and its association with coronary artery disease. We conducted a case-control study with 88 adults (42 cases and 46 controls) individually interviewed. Using a spiritual well-being scale and collecting socioeconomic and demographic information. We compared groups by Chi-square and Mann-Whitney tests. Friedman's analysis of variance was used to evaluate the differences between the values assigned to the scale items in each group. Statistically, there was no significant difference between categories and levels of spiritual well-being in any of the groups. Both had high rates, driven by the high level of religious well-being. There was no difference between the rates attributed to the items on the subscale of religious well-being, in the case or control groups (p = 0.959 and p = 0.817). However, the existential well-being subscale revealed variability between the scores attributed to each item in both groups (p < 0.001). The results revealed a high level of spiritual well-being in the analyzed sample. There was no correlation between the levels of spiritual, religious, and existential well-being with coronary artery disease, possibly due to the reduced ability of the religious well-being subscale to discriminate between groups.

Reality and some Factors Related to Treatment Adherence in HIV/AIDS Children at Outpatient Clinic, Vietnam National Children’s Hospital

Purpose: To characterize the prevalence and factors associated with ARV adherence in HIV/AIDS-infected children at outpatient clinics, Vietnam National Children's Hospital.&#x0D; Methods: A cross-sectional study was conducted at outpatient clinics, Vietnam National Children's Hospital in 2019.&#x0D; Results: The study results showed that 63% of HIV/AIDS infected children adhered to treatment and 37% of them did not adhere to ARV. The study investigated the relevance of 11 factors and found 5 factors related to pediatric noncompliance, including a short treatment period of less than 1 year (OR: 17.1; 95% CI: 2,26-75,5 and p &lt; 0,01); waiting time for taking drugs is too long (OR: 19.3; 95% CI: 7.9-50.9 and p &lt; 0.01); main caregivers aged ≥ 50 (OR = 42.3; 95% CI from 17.9-120.1 and p &lt; 0.01.&#x0D; Conclusions: The prevalence of ARV adherence in HIV/AIDS-infected children was 63%. Counseling intervention models to improve drug treatment compliance should be concentrated on newly infected children, treatment duration less than 1 year and their primary caregivers over 50 years old.

HİPERTANSİYON TANISI OLAN HASTALARDA BİLGİ DÜZEYİ VE İLAÇ TEDAVİSİNE UYUMUNUN DEĞERLENDİRİLMESİ

Aim: This study was conducted to determine the relationship between hypertension knowledge levels and compliance with drug treatment of patients diagnosed with hypertension.Methods: This descriptive-relationship-seeking study was conducted at a university hospital in the Aegean Region between June and September 2017. The sample of 193 individuals diagnosed with hypertension, selected by improbable random sampling method, was the sample of the study. In the study, the data were collected using the Patient Information Form, Hypertension Information Level Scale (HIB-DS) and Antihypertensive Drug Treatment Compliance Scale. In the analysis of the data; percentage rate, frequency, mean, chi-square, Kruskal Wallis, Mann Whitney-U tests and Spearman correlation analysis were used.Results: The mean age of the participants was 56.6±9.6 years and the diagnosis period of hypertension was 7.1±5.6 years. The mean score of Hypertension Information-Level Scale (HIB-DÖ) was 11.9 ± 5.6, and the mean score of Antihypertensive Drug Therapy Scale was 8.0±2.1. It was determined that 63.7% of the participants were incompatible with antihypertensive drug treatment.Conclusions: In this study, hypertension knowledge levels and compliance with antihypertensive drug therapy were low in patients with hypertension; It was determined that as the knowledge levels of hypertension increased, their compliance with antihypertensive drug treatment decreased.

An overview of glucagon-like peptide-1 receptor agonists for the treatment of metabolic syndrome: A drug repositioning.

Metabolic syndrome (MetS) is a clustering of several cardiovascular risk factors that include: obesity, dyslipidemia, hypertension and high blood glucose, and often requires multidrug pharmacological interventions. The management of MetS therefore requires high healthcare cost, and can result in poor drug treatment compliance. Hence drug therapies that have pleiotropic beneficial effects may be of value. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are the newest anti-diabetic drugs that mimic incretin effects in the body. They appear to be safe and well tolerable. Herein, the pharmacology of GLP-1RAs, their side effects, drug interactions and their effects in MetS is assessed. We conducted a Google Scholar, PubMed, Scopus, and Web of Science search since 2010 to identify publications related to the use of GLP-1RAs in treating component features of the MetS. Keywords used for the search were: GLP-1 receptor agonist, exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, MetS, obesity, triglyceride, cholesterol, lipid, hypercholesterolemia hyperlipidemia, atherosclerosis, hypertension, blood pressure, hyperglycemia, hypoglycemia and blood glucose. According to the gathered data, GLP-1RAs appear safe and well tolerated. Pre-clinical and clinical studies have evaluated the lipid-lowering, anti-atherosclerotic, anti-hypertensive and anti-diabetic effects of this class of drugs. Some these effects are related to a reduction in food-seeking behavior, an increase in atrial natriuretic peptide level and hence vascular relaxation and natriuresis, and an increase of pancreas β-cell mass and protection against glucotoxicity. Collectively, this review indicates that there may be some value in GLP-1RAs repositioning to manage MetS risk factors beyond their anti-diabetic effects.

Path Analysis on the Determinants of Adherence to Anti Tuberculosis Drug Treatment in Kaur District, Bengkulu, Indonesia

Background: Drug treatment compliance was the behavior of patients to take medication and undergo treatment according to the rules determined by professional health personnels. Many factors influenced the compliance with treatment for tuberculosis patients. This study aimed to examine determinants of drug treatment compliance among tuberculosis patients. Subject s and Method: This was an analytic observational study with a cross-sectional design. The study was conducted at 16 community health centers in Kaur Regency, Bengkulu, Indonesia, from January to February 2019. A sample of 206 study subjects was selected by purposive sampling. The dependent variable was drug treatment adherence. The indepen­dent variables were age, gender, education, income, knowledge, role of drug taking supervisor, side effect of drug treatment, distance to health service, drug availability, family support, and tenure. The data were collected by questionnaire and analyzed by path analysis. Results : Adherence to anti tuberculosis treatment was directly and positively affected by age (b= 2.96; CI 95%= 1.12 to 4.79; p= 0.002), gender (b= 1.48; CI 95%= 0.02 to 2.95; p= 0.047), education (b= 2.18; CI 95%= 0.24 to 4.11; p= 0.027), income (b= 0.85; CI 95%= 0.76 to 2.45; p= 0.031), knowledge (b= 2.27; CI 95%= 0.32 to 4.22; p= 0.023), the role of drug taking supervisor (b= 3.46; CI 95%= 1.57 to 5.36; p<0.001), drug availability (b= 0.04; CI 95%= -6.07 to 6.16; p= 0.989), and family support (b= 2.97; CI 95%= 1.30 to 4.64; p<0.001). It was negatively affected by the side effects of the drug (b= -3.07; CI 95%= -4.90 to -1.24; p= 0.001), distance to health service (b= -1.86; CI 95%= -3.61 to -0.11; p= 0.037), and tenure (b= -2.16; CI 95%= -3.95 to -0.38; p= 0.017). Adherence to anti tuberculosis treatment was indirectly affected by income, knowledge, and role of drug treatment supervisor. Conclusion: Adherence to anti tuberculosis treatment is directly and positively affected by age, gender, education, income, knowledge, the role of drug taking supervisor, drug availability, and family support. It is negatively affected by the side effects of the drug, distance to health service, and tenure. Keywords : treatment adherence, tuberculosis, determinants, path analysis Correspondence: Surahman Hamidi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: surahmanhamidi@student.uns.ac.id. Mobile: 085267­456713. Journal of Epidemiology and Public Health (2019), 4(3): 205-214 https://doi.org/10.26911/jepublichealth.2019.04.03.08

A3674 Effect of Intervention on Prevention and Control of Hypertension

Objectives: To explore the effect of group intervention on prevention and control of hypertension. Methods: Select a similar working environment, aged 20–60 in the study of about 2000, according to the ratio of 3: 1 were randomly divided into management group and conventional group, the management group to carry out primary prevention of cardiovascular disease and screening of hypertensive patients Education and management Reason. Conventional group in accordance with the current routine management practices required to work, not to accept the project team training and intervention.Evaluation of the two groups before and after intervention related indicators. Results: After the intervention of the management group, the knowledge score and the awareness rate of hypertension were all higher than those before the intervention and the intervention of the control group (P < 0.05); after the intervention of the management group, drug treatment), physical exercise were significantly higher than those before intervention, and the drug treatment and physical activity compliance were higher than that of the control group after intervention (P < 0.05) Pressure, total cholesterol, fasting blood glucose were lower than before intervention (P < 0.05), diastolic blood pressure was no significant difference (P > 0.05). Conclusion: Group intervention management model can better prevent and control hypertension and other cardiovascular diseases and development, can improve blood pressure in patients with hypertension, improve patient compliance and self-efficacy medication.Briefly discuss the data and emphasize the significance of the results.

Self-assessment of treatment compliance with antimuscarinic drugs and lower urinary tract condition among women with urinary incontinence.

Our aim was to determine the efficiency of the Medication Compliance Self-Report Inventory (MASRI) in self-reporting antimuscarinic drug treatment compliance among women with urinary incontinence (UI). The study assessed 347 women aged 18-65 (averaging 49.7) years with more than one urinary incontinence (UI) episode per day. Treatment compliance was tested at the beginning and at weeks 4, 8, and 12 using the MASRI, the Brief Medication Questionnaire (BMQ), and visual pill counts. The MASRI's constructive, concurrent, and discriminate validity was studied in comparison with an external standard that uses the chi-square and Spearman coefficient. Receiver operating characteristic (ROC) analysis was performed to identify optimum MASRI cutoffs that would predict noncompliance. Furthermore, the functional condition of the lower urinary tract was tested using voiding diaries, uroflowmetry, and cystometry. The correlation between the percentage of noncompliant women according to the MASRI, and individuals with a belief barrier with respect to the BMQ screen was r = 0.81 (p ≤0.05), r = 0.84 (p ≤0.05), and r = 0.79 (p ≤0.05). The correlation between the percentage of noncompliant women according to the MASRI and of women who missed >20% of their doses according to the Regimen Screen of the BMQ was r = 0.79, p ≤0.05, r = 0.82, p ≤0.01, r = 0.77, and p ≤0.05 at the control points. Finally, the percentage of noncompliant patients who self-reported correctly according to the MASRI data compared with the BMQ was 95.6%, 95.7%, and 96.6% at the control points. The MASRI entails acceptable validity for accurately predicting treatment compliance with antimuscarinic drugs among women who have had UI for >3 months.

Psychosocial skill training applied to schizophrenia patients at community mental health center and the results

Objective: Although the first choice for the treatment of schizophrenia is drugs, using merely the drugs is insufficient to treat schizophrenia. The main purpose of the study is to provide Psychosocial Skills Training (PSST) to a group of patients who have been treated and consulted by the Community Mental Health Center; and also to test the argued benefits of the treatment comparing the patients with a control group. Methods: Sixty patients who had been receiving regular outpatient treatment at Kucukcekmece Community Mental Health Center and who met the study criteria were chosen as the participants of the study. Both the study group and the control group were composed of 30 patients each, totally 60 patients. The PSST group was divided into three subgroups and the training was given in two sessions each of which lasted forty five minutes. Totally 18 sessions were conducted in approximately five months. The test battery was applied to both the study and the control groups by the researcher at the beginning and at the end of the study. In the test battery, the following tests were applied to the patients: Socio Demographic Data Form, Positive and Negative Syndrome Scale (PANSS), Calgary Schizophrenia Depression Scale (CSDS), Schedule for Assessing the Three Components of Insight (SATCI), Drug Treatment Compliance Rating Scale in Patients with Psychotic Disorders (DTCRS), Quality of Life Scale for Schizophrenia Patients (QLSSP), Social Functionality Scale (SFS). Results: When two groups were compared at the beginning and at the end of the study, significant difference was observed in negative symptoms sub-scale, general psycho-pathology sub-scale and PANSS total points. In the study group, the points of CSDS, SATCI, DTCRS, QLSSP, SFS improved/increased significantly after the training. Conclusion: For the treatment of chronic mental diseases such as schizophrenia, which is characterized by notable malfunctioning in the socialization and functionality of the patients, psychosocial approaches have become quite popular and agreed upon methods. Adding PSST to the treatment of schizophrenia patients whose routine policlinic follow-up activities were performed regularly has caused considerable improvement in psychopathologies, depression levels, insight, compliance, life qualities and functionalities of the patients.

Effect of family functions of postoperative patients with coronary intervention treatment on drug treatment compliance

Objective To explore effect of family function of the interventional heart surgery patients on the drug treatment compliance. Methods Compliance behavior and influence factors of 126 heart patients with interventional operation were investigated by questionaire. Results Family functions was important factor affecting the heart surgery patients drug treatment compliance. Compliance of patients from high-function family was good, who should be encouraged and guided. Conclusion Clinical doctors should encourage and guide the poor family functions of the patients, take positive way to deal with, to better control diseases and improve the quality of life. Family members should be paid more attention, as far as possible some more care, love, understanding and support patients Key words: Interventional heart surgery; Family functions; Drug treatment compliance

Factors that interfere the medication compliance in hypertensive patients.

ABSTRACTObjective:To characterize the factors that interfere in drug treatment compliance in a group of individuals with arterial hypertension.Methods:A non-experimental descriptive study that analyzed a sample of 80 patients diagnosed with arterial hypertension, who underwent medical treatment and were admitted to a university hospital during the period from March to May 2009. To collect data, the Instrument for Evaluation of Attitudes Regarding Taking Medication was applied.Results:In the studied population, 45.1% had sufficient degree of compliance to drug therapy. Individuals with controlled blood pressure, females, white, single, married or widowed, retired, aged between 40 and 59 years, and those aged above 80 years were the interviewees who answered positively regarding compliance and follow-up of drug therapy.Conclusion:Despite the fact that the number of factors that facilitate the process of compliance to drug treatment is greater than the number of complicating factors, we found that more than half of the patients surveyed had an insufficient degree of compliance with drug treatment for high blood pressure, which demonstrates the need to develop studies aimed to identify these factors and their contribution to the promotion of patient autonomy, acceptance, awareness and adaptation regarding their illness.