Abstract: Pharmaceutical medication serialization is often a regulatory requirement established by large nations to combat pharmaceutical drug counterfeiting. Since the 19th century, drug fraud has been a serious issue for the healthcare sector. The regulator y and healthcare organizations struggle from time to time to reduce the danger of negative outcomes brought on by fake medications. According to estimates from the World Health Organization (WHO), four out of every ten pharmaceuticals sold in underdeveloped or disadvantaged nations may be tainted. Ultimately, because of stolen, diverted, and counterfeit pharmaceuticals, drug makers lose billions of dollars annually. The regulatory authorities are currently developing severe regulations to prevent criminals from supplying and diverting fake or stolen medicine in the supply chain. To offer patients with safe and authentic medications, the healthcare business needs strict rules and secure traceability technologies. In essence, pharmaceutical drug serialization offers benefits by enhancing the supply chain's drug security by lowering adverse occurrences and investigations. Additionally, tracking and tracing technology is used in pharmaceutical drug serialization to take advantage of the advantages of tracking individual drug packages in the supply chain.