Drug Molecular Structure Research Articles

Microcalorimetric studies on the binding of some benzodiazepin derivatives to human serum albumin

The authors have employed a microcalorimetric method to study the nature of the interactions between several benzodiazepin molecules and human serum albumin. The thermodynamic functions of complexation have been determined at different pH, ionic strength and electrolyte support conditions. Both electrostatic and hydrophobic interactions have been demonstrated to exist in proportions which vary according to the drug's molecular structure.