<i>Purpose:</i> To study the influencing factors of the time limit for maintaining abstinence of drug addicts and provide a scientific basis for the formulation of targeted intervention to extend the time limit of ethics. <i>Methods: </i>A total of 237 individuals were randomly selected from 23,350 individuals who were released from compulsory isolation for drug addiction and received long-term follow-up from December 1, 2010 to December 1, 2020. Among them, 215 individuals had relapsed after drug withdrawal (with a duration of maintaining abstinence ranging from 0 to 120 months), and 22 individuals had maintained abstinence after drug withdrawal for more than 120 months were used as the research objects. The relapse reasons self-assessment scale, social regression factors self-assessment scale, and three-dimensional personality scale-curiosity subscale were used to conduct a questionnaire survey to analyze the psychological and social factors influencing drug abuse patients. <i>Results:</i> The differences in the number of times of drug withdrawal, education level, marital status, and duration of drug abuse among drug withdrawal patients with different durations of maintaining abstinence were statistically significant (P < 0.05). The differences in the relapse reasons self-assessment scale among drug withdrawal patients with different durations of maintaining abstinence, such as physiological symptoms, job discrimination, drug-related temptations, rehabilitation effects, and social regression factors such as family acceptance, police acceptance, community services, and drug prohibition policies, were statistically significant (P < 0.05). Except for no significant difference with the control group in NS1 (only significant differences were found in the 49-60 month group, P < 0.05), the differences between drug withdrawal patients with different durations of maintaining abstinence and the control group in NS2, NS3, and NS4 were statistically significant (P < 0.05). <i>Conclusion:</i> Factors affecting relapse include drug-related temptations, rehabilitation effects, job discrimination, family and friends' rejection, psychological symptoms, and personality traits; Factors affecting social regression include family acceptance, economic income, drug prohibition policies, fair treatment, and job opportunities. To intervene in the factors leading to relapse in drug abuse patients, attention should be paid to the first withdrawal, education level, physiological symptoms, job discrimination, drug-related temptations, rehabilitation effects, family acceptance, police acceptance, community services, and drug prohibition policies.