Summary The historical aspects of opiate dependence in the United Kingdom have been briefly reviewed. Recent practice is governed by the 1971 Misuse of Drugs Act . There is a legal obligation for medical practitioners in the UK to notify individuals they find to be addicted to opiate drugs, to the Chief Medical Officer of the Home Office. Official statistics (collected by the Home Office) provide a broad impression of the trend of opiate related problems and represent the tip of the iceberg in their attempt to quantify the problem in the UK. Local variations, as well as rapid changes in the availability of drugs in any particular location, make it essential to study the incidence of drug problems in relatively small areas. A broad range of prescribed opioid drugs can lead to dependence; however the majority of patients seen in drug dependency units are addicted to heroin bought as a powder at ‘street level'. Those who become dependent on opiate drugs tend to be young adults, males outnumbering females two to one; they would appear to be from all social classes. Whilst most individuals presenting at DDUs will be unemployed and have criminal records, this is not an invariable stereotype. Damage associated with opiate dependence can be divided into social, mental and physical spheres. Social harm is most obvious in the realms of d deterioration in personal relationships, conflict with the Law and difficulty in sustaining employment. Physical harm relates closely to the method of administration of the drug, intravenous opiate addicts being at particular risk of developing hepatitis and HIV infection; opiate addicts show high incidence of venereal infection. Mental harm includes deterioration of personality and depression. Psychotic illnesses as a response to opiate dependence are unlikely to occur. Repeated administration of opiates leads to a rapid build-up of tolerance, and a well-recognized abstinence syndrome will occur when such drugs are withdrawn abruptly. Withdrawal can be managed using methadone linctus by mouth as a substitute drug. It is essential to treat psychological dependence, once physical aspects of withdrawal are under control. Children born to mothers addicted to opiates are likely to show withdrawal symptoms and will require special attention during the neonatal period. Studies of the longer term prospects of opiate addicts suggest that, in the course of a 10-year period, approximately 20% will die, 40% will survive showing a marked increase in their stability and decrease in their drug misuse, and the remaining 40% are likely to spend increasing periods in custody or survive as a result of repeated episodes of treatment. This account of opiate dependence concentrates heavily on the current situation in the UK, drawing deliberately on recent studies, as opiate dependence is a rapidly changing problem, many aspects of which will be specific to the community within which it occurs. The principles of management tend to remain the same whatever the setting.