This paper evaluates the influence of different variables on drivers’ willingness to accept and use a vehicle-mounted perfume automatic dispersal device (VP-ADD) connected to the vehicle’s electronic map. Based on the technical acceptance model, we clarify and condense the explanation of the model used to evaluate the impact of user behavior attitudes and device characteristics on six factors, perceived usefulness, perceived ease of use, attitude towards use, intention to use, perceived playfulness, and perceived risk, proposing eight hypotheses. Then, we assessed the responses of 562 drivers in China using SPSS for reliability and validity and AMOS for structural equation modeling to test our hypotheses. The findings reveal that the perceived usefulness, ease of use, playfulness, and risk significantly affected the willingness to accept and use the VP-ADD. Furthermore, the perceived risk has a negative influence, while the perceived usefulness, perceived ease of use, perceived playfulness, and attitude towards use have a positive influence. This research is significant for further development and application of the VP-ADD. It is essential to alleviate driver fatigue, ensure traffic safety, and provide theoretical and empirical support for designing more popular driving assistance devices. Furthermore, it offers valuable insights for developing fatigue driving warning policies, in-vehicle device guidelines, and traffic safety regulations.