Background:Slow eye movements (SEMs), which occurs during eye-closed periods with high time coverage rate during simulated driving process, indicate drivers’ sleep onset. New Method:For the multi-scale characteristics of slow eye movement waveforms, we propose a multi-scale one-dimensional convolutional neural network (MS-1D-CNN) for classification. The MS-1D-CNN performs multiple down-sampling processing branches on the original signal and uses the local convolutional layer to extract the features for each branch. Results:We evaluate the classification performance of this model on ten subjects’ standard train–test datasets and continuous test datasets by means of subject-subject evaluation and leave-one-subject-out cross validation, respectively. For the standard train–test datasets, the overall average classification accuracies are about 99.1% and 98.6%, in subject-subject evaluation and leave-one-subject-out cross validation, respectively. For the continuous test datasets, the overall average values of accuracy, precision, recall and F1-score are 99.3%, 98.9%, 99.5% and 99.1% in subject-subject evaluation, are 99.2%, 98.8%, 99.3% and 99.0% in leave-one-subject-out cross validation. Comparison with existing method:Results of the standard train–test datasets show that the overall average classification accuracy of the MS-1D-CNN is quite higher than the baseline method based on hand-designed features by 3.5% and 3.5%, in subject-subject evaluation and leave-one-subject-out cross validation, respectively. Conclusions:These results suggest that multi-scale transformation in the MS-1D-CNN model can enhance the representation ability of features, thereby improving classification accuracy. Experimental results verify the good performance of the MS-1D-CNN model, even in leave-one-subject-out cross validation, thus promoting the application of SEMs detection technology for driver sleepiness detection.