Acoustic droplet vaporization (ADV) is the phase transition of liquid droplets into gas microbubbles via ultrasound. Oxygen diffuses from the surrounding fluid into the microbubbles. This study determined the efficiency of oxygen scavenging using a lipid decafluorobutane (DFB) nanoemulsion. DFB nanoemulsions were prepared using high-shear pressure homogenization. Nanoemulsion size distributions and concentrations were measured (n = 10) using a Beckman Coulter Multisizer 4. Oxygen scavenging in 95% oxygenated water was measured in a flow phantom prior to introducing DFB nanoemulsion at concentrations of 0.05 × 10−4, 0.25 × 10−4, 0.5 × 10−4, 2.5 × 10−4, and 5 × 10−4 mL/mL and with ADV nucleated by an EkoSonic catheter driven with 47 W electrical power. The DFB nanoemulsion had a modal diameter of 920 ± 60 nm, polydispersity index (PDI) of 0.11 ± 0.03, and concentration of 3.11 × 10–2 ± 0.01 × 10–2 mL/mL. No statistical significant differences was detected in droplet size distribution metrics for at least 5 h at room temperature and 23 days at 4C. The baseline oxygen partial pressure (pO2) of the water was 553 ± 8 mmHg for all experiments. Peri-ADV pO2 dropped to 505 ± 16, 398 ± 44, 348 ± 11, 231 ± 27, 241 ± 7 mmHg for increasing concentration. A significant difference in pO2 was seen between thelowest and highest concentration (p = 0.0097). The computed ADV transition efficiency was highest at 0.25 × 10−4 mL/mL.
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