Droplet Distribution Research Articles

Exploring the emulsification potential of chitosan modified with phenolic acids: Emulsifying properties, functional activities, and application in curcumin encapsulation

This study successfully grafted caffeic acid and 3,4-dihydroxybenzoic acid into chitosan through a coupling reaction, yielding grafting ratio of 8.93 % for caffeic acid grafted chitosan (CA-GC) and 9.15 % for 3,4-dihydroxybenzoic acid grafted chitosan (DHB-GC) at an optimal concentration of 4 mmol phenolic acids. The characterization of modified chitosans through ultraviolet visible spectrometer (UV–vis), Fourier transform infrared spectrometer (FTIR), proton nuclear magnetic resonance (1H NMR), and x-ray photoelectron spectrometer (XPS) confirmed the successful grafting of phenolic acids. In the subsequent step of emulsion preparation, confocal laser scanning microscope images confirmed the formation of O/W (oil-in-water) emulsions. The phenolic acid-grafted chitosans exhibited better emulsification properties compared to native chitosan, such as reduced droplet size, more uniform emulsion droplet distribution, increased ζ-potential, and enhanced emulsifying activity and stability. Moreover, the modified chitosans demonstrated increased antioxidant activities (evidenced by DPPH and β-carotene assays) and displayed greater antimicrobial effects against E. coli and S. aureus. Its efficacy in curcumin encapsulation was also notable, with improved encapsulation efficiency, sustained release rates, and enhanced storage and photostability. These findings hint at the potential of modified chitosans as an effective emulsifier.

Comparative Study of Droplet Diameter Distribution: Insights from Experimental Imaging and Computational Fluid Dynamics Simulations

The interfacial area between two phases plays a crucial role in the mass transfer rate of gas–liquid processes such as absorption. In this context, the droplet size distribution within the flow field of a droplet-based absorber significantly affects the surface area, thereby influencing the absorption efficiency. This study focuses on developing a computational fluid dynamics (CFD) model to predict the size and distribution of water droplets free-falling in a transparent square tube. This model serves as a digital twin of our experimental setup, enabling a comparative analysis of experimental and computational results. For the accurate measurement of droplet size and distribution, specialized experimental equipment was developed, and a high-speed camera along with Fiji software was used for the capturing and processing of droplet images. At the point of injection and at two different heights, the sizes and distributions of falling droplets were measured using this setup. The interaction between the liquid water droplets and the gas phase within the square tube was modeled using the Eulerian–Lagrangian (E-L) framework in the STAR-CCM+ software. The E-L multiphase CFD model yielded approximations with errors ranging from 11 to 27% for various average mean diameters, including d10, d20, d30, and d32, of the liquid droplets at two distinct heights (200 mm and 400 mm) for both nozzle plates. This comprehensive approach provides valuable insights into the dynamics of droplet-based absorption processes.

Effect of TEMPO-oxidized bacterial cellulose nanofibers stabilized Pickering emulsion of cinnamon essential oil on structure and properties of gelatin composite films

Pure gelatin film often exhibits high hydrophilicity and a lack of antibacterial activity, hindering its practical application in the field of food preservation. To address these issues, we incorporated 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized bacterial cellulose (TOBC) nanofibers stabilized cinnamon essential oil (CEO) Pickering emulsions into the gelatin matrix to develop active food packaging films. The study revealed that the good distribution of emulsion droplets in the film matrix. While with increasing Pickering emulsion proportion, the microstructures of composite films were more heterogeneous, showing some pores or cavities. In addition, the insertion of TOBC-stabilized CEO emulsions could improve the elongation at break (EAB), water-resistance, UV blocking ability, and antibacterial activity of film, but reduced its tensile strength (TS) and water vapor barrier properties (WVP). Notably, the film prepared with 4 % TOBC-stabilized CEO Pickering emulsion demonstrated enhanced preservation of strawberries. Overall, the as-prepared gelatin-based active composite films have considerable potential for food packaging.

Unlocking stability and efficiency in benzyl isothiocyanate-loaded emulsions: Unveiling synergistic interactions of fish skin gelatin and pectin

In this research endeavor, a novel emulsion delivery system was devised to enhance the retention of the fat-soluble active substance known as benzyl isothiocyanate (BITC). Fish skin gelatin (FSG) and pectin (PEC) were chosen as complex emulsifiers and collectively referred to as FSG-PEC. The interaction between FSG and PEC was examined by turbidity, flourier transform infrared, fluorescence, ultraviolet, methylene blue, and molecular docking. Emulsification activity, emulsification stability, contact angle, appearance structure, average particle size, zeta potential, oil droplet distribution, and retention rate of the encapsulated BITC, were evaluated to determine the optimal concentration ratio of the FSG-PEC complex for effectively safeguarding BITC. The results showed that the turbidity of FSG and PEC was minimal at pH 7, indicating relative stability of the complex. The primary molecular forces between FSG and PEC were electrostatic and hydrogen bond interaction. The interfacial stability, emulsifying activity and stability of FSG-PEC complex at a 2:1 ratio surpassed those of other ratios. Consequently, this optimal ratio was utilized to prepare FSG-PEC emulsion delivery system containing BITC. The resulting emulsion, stored for 14 days at 4 °C, demonstrated compelling attributes with a particle size of 433.33 ± 1.12 nm, a potential of −32.87 ± 0.35 mV, and a BITC retention rate of 59.87 ± 0.65%. The combination of the indicators finally concluded that 2:1 was the optimal ratio to construct the FSG-PEC complex emulsion delivery system. This study constitutes an initial exploration of the interaction dynamics between FSG and PEC, providing a theoretical foundation for subsequent applications.

Cellulose nanofibrils-stabilized food-grade Pickering emulsions: Clarifying surface charge's contribution and advancing stabilization mechanism understanding

Pickering emulsions stabilized by cellulose nanofibrils (CN) have sparked significant attention, however the fundamental mechanisms underpinning the stabilization process remain insufficiently elucidated. Focusing on an academic debate of surface charge's contribution to stabilization, this study first explored how the varying carboxyl group contents of TEMPO-oxidized CN (TCNs) impacted Pickering emulsions' formation and stability. TCNs with 662 μmol/g carboxyl groups exhibited distinctive attributes, including larger particle sizes (322 nm in length), improved thermal stability (maximum decomposition temperature of 317 °C), and increased viscosity (1.57 Paִִ⋅s) compared to their counterparts with 963–1011 μmol/g charge density. Notably, the former one, with a larger three-phase contact angle (51.5°), higher interfacial tension, and greater detachment energy (21.69 × 10−18 J), resulted in a homogeneous dispersion of spherical oil droplets and super-stable Pickering emulsions with a consistent emulsifying index of 100% over 30 days. These findings clearly clarified that TCNs with a lower charge density exhibit superior emulsifying properties. In addition, for the first time, a distinct oil droplet-decorated fibrillar structure was observed, probably suggesting that TCNs might be able to serve as anchoring matrixes to guide the distribution of oil droplets. These structures seemed to impeded the migration and accumulation of the oil droplets, consequently enhancing the stability of the resulting Pickering emulsions. To sum, this study clearly elucidated the role of surface charge in stabilizing cellulose-based Pickering emulsions and proposed a new model to expound the cellulose-oil interaction mechanisms, thus providing new theoretical and practical insights on utilization of CN as highly effective emulsifier for super-stable food-grade Pickering emulsions.

Effect of LDL Extracted from Human Plasma on Membrane Stiffness in Living Endothelial Cells and Macrophages via Scanning Ion Conductance Microscopy.

Mechanical properties of living cells play a crucial role in a wide range of biological functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion-Conductance Microscopy (SICM) correlated with confocal imaging and demonstrated the topographical changes and mechanical properties alterations in EA.hy926 and THP-1 exposed to LDL extracted from CVD patients' blood samples. We show that the cells stiffened in the presence of LDL, which also triggered caveolae formation. Endothelial cells accumulated less cholesterol in the form of lipid droplets in comparison to THP-1 cells based on fluorescence intensity data and biochemical analysis; however, the effect on Young's modulus is higher. The cell stiffness is closely connected to the distribution of lipid droplets along the z-axis. In conclusion, we show that the sensitivity of endothelial cells to LDL is higher compared to that of THP-1, triggering changes in the cytoskeleton and membrane stiffness which may result in the increased permeability of the intima layer due to loss of intercellular connections and adhesion.

Experimental investigation of surface wettability on frosting propagation characteristics

The frost propagation process on surfaces plays a crucial role in the initial stages of surface condensation frosting, making it a significant aspect of the entire process. To investigate the relationship between surface wettability and the frost propagation velocity during condensation frosting, a microscopic visualization experiment platform was established. Three high-reflectivity surfaces with varying wettability were prepared to meet the experimental requirements. The frost propagation process can be divided into two stages: the freezing of intra-droplet and the ice bridge propagation between droplets. Experiment results revealed that the primary factor affecting the propagation speed of the ice bridge is the distance between the ice bridge and the droplet. As this distance reduces from approximately 16 μm to 2 μm, the propagation velocity of the ice bridge increases dramatically from around 2 μm/s to about 12 μm/s. Furthermore, the overall frost propagation velocity on surfaces with different wettability properties, were evaluated. The results indicate that the significant difference in droplet distribution characteristics and ice bridge propagation coefficients on superhydrophobic surfaces is the cause of slow frost formation during frosting on cold surfaces. This study identifies the key factor affecting the frost propagation and the inhibition of frost formation, namely, the droplet size distribution characteristics of superhydrophobic surfaces. These insights and findings provide a foundation for the design and optimization of anti-frost surfaces.

The Enhancement of Oil Delivery and Bearing Performance via a Guiding-Structured Nozzle under Oil–Air Lubrication

The oil–air lubrication method is specifically employed for high or ultra-high-speed spindle rolling bearings. Under high-speed conditions, the air curtain formed inside the bearing cavity obstructs oil delivery, thereby limiting further increases in spindle rotation speed. To enhance oil delivery capability, a guiding-structured nozzle has been developed to concentrate the jet flow and improve penetration through the air curtain. Tests were conducted on an oil–air lubricated bearing test bench to investigate the impact of nozzle structures and oil types on torque and temperature rise. The results demonstrate that compared to conventional nozzles, the guiding-structured nozzle requires smaller optimal amounts of oil supply, indicating its superior ability to deliver oil. Further examination of oil jet patterns and droplet distributions confirms that the guiding-structured nozzle provides a more concentrated jet flow with uniform distribution and smaller droplet sizes in diameter. These characteristics contribute to highly efficient oil delivery. Additionally, synthetic oils reduce droplet size, torque, and temperature rise in mixed lubrication regimes due to their formation of an anti-friction absorption layer on rubbing surfaces.

Using a New Fe3O4@CPAM Magnetic Flocculant and Microwave to Demulsify Heavy Oil-in-Water Emulsions.

In this study, cationic polyacrylamide (CPAM)-coated magnetic nanoparticles (MNPs) Fe3O4@CPAM were synthesized for treating heavy O/W emulsions. This Fe3O4@CPAM was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM) techniques, and its synergistic performances with microwaves were evaluated in detail with respect to the microwave radiation power, radiation time, and magnetic nanoparticle concentration. On this basis, the distribution of oil droplets and the wettability and chargeability of magnetic nanoparticles were measured without or with microwave radiation using biomicroscopy, contact angle measurement instrument, and a ζ-potential analyzer, thus revealing the synergistic demulsification mechanism between microwave and magnetic nanoparticles. The results showed that excessively high or low microwave radiation parameters had an inhibitory effect on the magnetic nanoparticle demulsification, and microwave promoted the magnetic nanoparticle demulsification only when the radiation parameters were in the optimal range. In addition, the water separation rate showed an increasing and then decreasing trend with the increase of magnetic nanoparticles concentration, with or without microwave action. As an example, the water separation rate of the emulsion for 1 h was 21.34% when the Fe3O4 concentration was 175 mg/L without microwave action, while it increased to 55.56% with microwave action. In contrast, when the concentration of Fe3O4@CPAM was 175 mg/L, the water separation rate was 42.86% without microwave radiation, while it was further increased to 77.38% under microwave radiation. These results indicate that magnetic nanoparticles and their complexes significantly affect the water separation process under different conditions. There is a more obvious coupling synergistic effect between Fe3O4@CPAM and microwave. This was due to the lower absolute potential of Fe3O4@CPAM and its higher hydrophobicity.

Size, Distribution, and Acoustic Impedance Quantization of Bubbles and Droplets Using Ultrasonic Complex Sound Pressure

Size, Distribution, and Acoustic Impedance Quantization of Bubbles and Droplets Using Ultrasonic Complex Sound Pressure

Experimental Investigation on the Symmetry and Stabilization of Ethanol Spray Swirling Flames Utilizing Simultaneous PIV/OH-PLIF Measurements

A detailed experimental study of ethanol spray swirling flames was performed in an axial bluff body stabilized burner. The characteristics of the non-reacting and reacting sprays were recorded by particle imaging velocimetry (PIV) and planar laser-induced fluorescence (PLIF) of the OH radical. A few typical flames with different structures (outer-side-flame-lifting, stable, and near-blow-off) were compared and analyzed. The parameters of the spray, including the spray half-angle (α) and droplet number density (nd), are quantified, and it has been found the flame structure and stability were strongly correlated with the droplet distribution. Several parameters of the flow field, such as velocity magnitude (|U| vorticity (ωz), and turbulent kinetic energy (TKE), are quantitively analyzed, and it is observed that the local strain rate rose as the air flow rate increased, which is not conducive to local flame stability. Regarding the flame, quantities such as progress variable (<c>), flame height (Lf), lift–off height (hlf), and symmetry factor (Snd and S<c>) are calculated, and it can be observed that the flame symmetry keeps worsening when approaching blow–off, and the inner flame branch exhibits a worse stabilization than the outer one. Our comprehensive investigations offer a deeper understanding of stable combustion in such two–phase flames.

Influence of Selected Compositions of Wall Materials and Drying Techniques Used for Encapsulation of Linseed Oil and Its Ethyl Esters

The aim of the study was to compare the encapsulation of linseed oil and its ethyl esters using two coating materials (maltodextrin with whey protein concentrate (WPC) vs. maltodextrin with gum arabic) and two drying methods (spray-drying vs. freeze-drying) to obtain powders with the highest oxidative stability. A comparison was made based on the properties of emulsions (morphology, particle size distribution, and stability) and powders (morphology, physicochemical properties, fatty acid composition, and oxidative stability). The powder’s oxidative stability was determined based on the Rancimat protocol. The most uniform distribution of oil droplets in prepared emulsions was stated for ethyl esters in a mixture of maltodextrin and gum arabic. Emulsions with WPC had a bimodal character, while those with gum arabic had a monomodal character. Gum arabic promoted emulsion stability, while in samples containing WPC, sedimentation and creaming processes were more visible. Powders obtained using spray-drying had a spherical shape, while those obtained by freeze-drying were similar to flakes. Although encapsulation efficiency was the highest for freeze-dried powders made of linseed ethyl esters with gum arabic, the highest oxidative stability was stated for powders made by spray-drying with WPC as wall material (independently of linseed sample form). These powders can be easily applied to various food matrices, increasing the share of valuable α-linolenic acid.

Cold-Pressed Sacha Inchi Oil: High in Omega-3 and Prevents Fat Accumulation in the Liver.

The ability of oil supplementation to inhibit various metabolic syndromes has been recognized. However, there are currently no studies determining the effects of oil supplements on healthy conditions. Plukenetia volubilis L., also known as Sacha inchi, is a seed rich in essential unsaturated fatty acids that improves metabolic syndrome diseases, such as obesity and nonalcoholic fatty liver. However, the health benefits and effects of Sacha inchi oil (SIO) supplementation remain unclear. This study aims to evaluate the chemical effects and properties of Sacha inchi oil. The results of the chemical compound analysis showed that Sacha inchi is an abundant source of ω-3 fatty acids, with a content of 44.73%, and exhibits scavenging activity of 240.53 ± 11.74 and 272.41 ± 6.95 µg Trolox/g, determined via DPPH and ABTS assays, respectively, while both olive and lard oils exhibited lower scavenging activities compared with Sacha inchi. Regarding liver histology, rats given Sacha inchi supplements showed lower TG accumulation and fat droplet distribution in the liver than those given lard supplements, with fat areas of approximately 14.19 ± 6.49% and 8.15 ± 2.40%, respectively. In conclusion, our findings suggest that Sacha inchi oil is a plant source of ω-3 fatty acids and antioxidants and does not induce fatty liver and pathology in the kidney, pancreas, and spleen. Therefore, it has the potential to be used as a dietary supplement to improve metabolic syndrome diseases.

Application of ultra-low-volume spray for the control of vegetable disease in greenhouse: Investigation of formulation performance and potential dermal exposure.

The use of pesticides in greenhouse vegetable cultivation is necessary and significant. However, traditional pesticide application methods such as the use of backpack sprayers with water-diluted pesticides have certain drawbacks, e.g., uneven distribution, high labor intensity, and safety risks. In this work, fluazinam ultra-low-volume liquids (Flu-ULVs) were prepared using oily solvents as carriers. The effects of different oils on the physical properties of the preparations were investigated. The Flu-ULV can be sprayed directly using a hand-held ultra-low-volume (ULV) sprayer without dilution with water. Compared with commercial water-based suspension concentrates of fluazinam, the Flu-ULV samples showed better wetting of tomato leaves, better atomization, and more uniform droplet distribution. At a dosage of 300 mL/ha, the coverage rate of tomato leaves ranged from 32.47% to 79.3%, with a droplet deposition density of 556 to 2017 droplets/cm2. Application of Flu-ULVs provided 70.86% control efficacy against gray mold in tomatoes, which was higher than those achieved with reference products. Dermal exposure to Flu-ULVs was also evaluated in greenhouse experiments. The coverage rates for all parts of the operator's body ranged from 0.02% to 0.07%, with deposition volumes of 2.23 to 12.26 μg/cm2. Ground ULV spraying of fluazinam was proved to be an effective and safe management option for the control of tomato gray mold in greenhouses. This study laid a foundation for the use of ultra-low volume spray to control vegetable diseases in greenhouse, especially those induced by high humidity environment. © 2024 Society of Chemical Industry.

Review of atomization characteristics of liquid jets in crossflow

The atomization process of liquid fuels is vital in scramjet engines. The level of atomization directly impacts the subsequent evaporation, mixing, and combustion processes. Therefore, understanding the atomization mechanism of liquid jets in crossflow is necessary to promote the mixing process of scramjet engines and improve the combustion efficiency. This article overviews the atomization process of liquid jets in transverse airflow based on the breakup mechanism, atomization characteristics, and factors affecting atomization. The deformation and fragmentation of droplets are influenced primarily by the Weber number and have little correlation with the Reynolds number. There are similarities in the properties between the primary fragmentation of liquid jets and the breakup of liquid droplets in crossflow. The primary breakup of liquid jets in crossflow is characterized primarily by continuous jet column breakup. The Rayleigh–Taylor instability causes columnar breakup, while the Kelvin–Helmholtz instability causes surface breakup in the jet. The size distribution of droplets follows C-, I-, or S-shaped distributions, while the velocity distribution of droplets follows an inverse C-shape. Finally, the shortcomings of current research are pointed out, namely, the lack of research on the jet breakup mechanism in crossflow under actual scramjet engine configurations and inflow conditions. In the future, it can be combined with artificial intelligence to reveal the jet breakup mechanism under actual working conditions and establish a wide range of theoretical prediction models.

Experimental investigation on liquid breakup regimes and spray characteristics in slinger atomizers with various injection orifices

Slinger atomizers, known as one type of rotary atomizers, have been widely applied in various small gas turbine engines. The fuel can be well atomized by taking advantage of the high rotational speed of the turbine shaft. The geometric characteristics of the injection orifice play an important role in determining the atomization performance of the slingers. The breakup regimes and the droplet size of the slinger atomizers with slot-shaped orifices have rarely reported in the past. Herein, three types of slinger atomizers with different orifice shapes and orifice diameters are tested at rotational speeds of 8000–20 000 rpm and liquid feed rates of 4 up to 20 g/s. High-speed shadowgraph imaging, high-speed digital imaging, and planar Mie technologies are applied to provide the spray breakup process, liquid film injection features, and droplet distribution, respectively. Spray visualizations show that the orifice diameters strongly affect the breakup modes, whereas the orifice shapes have a slight effect. The variation regarding droplet sizing under different heights from the slinger plane is analyzed. The uniformity of the droplet distribution in slot-shaped slinger atomizers is better than that in round-shaped slinger atomizers. Moreover, the smaller orifice diameter results in a small Sauter mean diameter (SMD) for the slinger atomizers with slot-shaped orifices. Finally, a mathematical expression is obtained to predict non-dimensional droplet size (SMD/d) for different slinger atomizers. The present results appear to be the first systematic investigation of the spray characteristics in slinger atomizers with slot-shaped orifices.

A Similarity Measurement Method of Normal Cloud Models for the Operational Status Perception and Computing of Urban Rail Transit

The similarity measurement method is the key part of the normal cloud model as well as its applications. Too much attention has been paid on geometric and numerical features, leading to the weak interpretability and unreasonable results in the similarity measurement method of the normal cloud models. A bidirectional and weighted similarity measurement (BWSM) method is proposed by the number distribution and membership of cloud droplets on a normal cloud model. First, the cloud droplets are analyzed, and their characteristics of number distribution and membership that belong to different cloud models are obtained. Second, the similarity measurement strategy of the normal cloud models is analyzed and used to propose a BWSM method, which is compared with two commonly used similarity measurement methods of normal cloud models. The influence of expectation, entropy, and hyper entropy on the similarity measurement method of the normal cloud models is analyzed. Finally, the method is applied on the operational status perception and computing of urban rail transit. Results show the method has high rationality, validity, and applicability for perceiving and computing the operational status of urban rail transit. The method improves the interpretability of the similarity measurement of the normal cloud models and the credibility of the research based on the similarity measurement of the normal cloud models.

Influence of tea leaf morphology on water interception for droplet impact

AbstractIt is common for plant canopy to intercept water during rainfall or sprinkler irrigation. How tea leaves intercept water droplets are unknown. The objective of this study is to investigate the influence of different shapes of tea leaves on the water droplet retention and distribution. First, the shapes of different tea varieties (Zhongcha 108, Maolu, Longjing 43, Huangjinya, and Anji Baicha) were statistically classified, and a high‐speed camera (with a frame rate of 10 000 fps) was used to record and analyse the interception of single droplet. The results showed that the morphology of tea leaves is flat, V‐shaped and hemispherical. The percentage of flat shaped leaves is the highest in each variety (45.38%–63.20%), the proportion of V‐shaped leaves is 30.40%–42.97%, and the proportion of hemispherical leaves is the least. When the impact velocity is 1.35 ± 0.05 m/s, it takes only 20–26 ms for droplet to start hitting each morphology of leaves and be retained as a static liquid. Droplets were kept as a film of water on the flat leaf, and similar situation happened to the hemispherical leaf, but they slid downward due to gravity. When impact position is near the midrib or leaf surface angle is smaller, retained droplets tends to converge to the bottom of the V‐shape with a symmetrical distribution. This study aids to better understand and model water interception within tea canopies for future practice of irrigation and chemical spraying.

In-flight imaging of aerosol jet printer droplets to enable spatially resolved flow rate measurements

The effect of process drift in aerosol jet (AJ) printing has been a hindering factor in its large-scale adoption in printed electronics. In this study, we developed an in situ droplet imaging system using a double-pulse laser to quantify the distribution and velocity of sparse droplets between the AJ printer nozzle and the substrate. The droplet velocity and distribution were then used to evaluate a spatially resolved droplet flow rate that was capable of detecting and quantifying process drift over time. Using the droplet imaging system, the effect of different focus ratios was analyzed. The droplet flow rate was shown to be indicative of the deposited line morphology for low to moderate focus ratios. At a high focus ratio, the tool was able to identify non-idealities in the fluid properties which are explained in a detailed analysis. AJ printing demonstrates significant promise for the additive manufacturing of electronics, and this work represents a step toward non-invasive, in-flight monitoring in real time.

Nanoparticle-Assisted Liquid Crystal Droplet Sensors Enable Analysis of Low-Concentration Species in Aqueous Medium.

We introduce nanoparticle-assisted liquid crystal (LC) droplet-based sensors that allow determination of low-level concentrations of aqueous soluble species. The silica nanoparticles functionalized with mixed monolayers composed of two distinct groups, hydrophobic alkane tail- and charged group-terminated silanes, facilitated ternary physical interactions between the model analytes (methylene blue (MB) or methyl orange (MO)) and the nematic mesogens 5CB (4-cyano-4'-pentylbiphenyl), and the interfacial species of the nanoparticle. The response of the LC droplets was measured upon nanoparticle adsorption as a function of analyte concentration, which was characterized by the optical determination of the configuration distributions of the LC droplets. We highlight the importance of the charging and the composition of the nanoparticle interfaces for analytical purposes that allow accurate determination of the concentration of the analytes on the order of 0.01 ppb. Such a low concentration corresponds to a low interfacial coverage of nanoparticles, indicating the promisingly high sensitivity of the sensor platform to target analytes. Distinct from the past examples of the LC-based sensors, the nanoparticle-assisted LC sensors allow detection of the species that do not directly cause an ordering transition at the LC-water interfaces, which allow a broader range of analytical targets. The sensor platform that we report herein can be easily tunable for a range of target molecules and will find use in the determination of a wide range of micropollutants in aqueous environments.