Altered movement patterns during single-leg movements in soccer increase the risk of lower-extremity non-contact injuries. The identification of biomechanical parameters associated with lower-extremity injuries can enrich knowledge of injury risks and facilitate injury prevention. Fifty-six elite youth soccer players performed a single-leg drop landing task and an unanticipated side-step cutting task. Three-dimensional ankle, knee and hip kinematic and kinetic data were obtained, and non-contact lower-extremity injuries were documented throughout the season. Risk profiling was assessed using a multivariate approach utilising a decision tree model (classification and regression tree method). The decision tree model indicated peak knee frontal plane angle, peak vertical ground reaction force, ankle frontal plane moment and knee transverse plane angle at initial contact (in this hierarchical order) for the single-leg landing task as important biomechanical parameters to discriminate between injured and non-injured players. Hip sagittal plane angle at initial contact, peak ankle transverse plane angle and hip sagittal plane moment (in this hierarchical order) were indicated as risk factors for the unanticipated cutting task. Ankle, knee and hip kinematics, as well as ankle and hip kinetics, during single-leg high-risk movements can provide a good indication of injury risk in elite youth soccer players.