Dry Powder Research Articles

Inhalable tobramycin EEG powder formulation for treating Pseudomonas aeruginosa-induced lung infection

Pulmonary delivery of antibiotics is an effective strategy in treating bacterial lung infection for cystic fibrosis patients, by achieving high local drug concentrations and reducing overall systemic exposure compared to systemic administration. However, the inherent anatomical lung defense mechanisms, formulation characteristics, and drug-device combination determine the treatment efficacy of the aerosol delivery approach. In this study, we prepared a new tobramycin (Tobi) dry powder aerosol using excipient enhanced growth (EEG) technology and evaluated the in vitro and in vivo aerosol performance. We further established a Pseudomonas aeruginosa-induced lung infection rat model using an in-house designed novel liquid aerosolizer device. Notably, novel liquid aerosolizer yields comparable lung infection profiles despite administering 3-times lower P. aeruginosa CFU per rat in comparison to the conventional intratracheal administration. Dry powder insufflator (e.g. Penn-Century DP-4) to administer small powder masses to experimental animals is no longer commercially available. To address this gap, we developed a novel rat air-jet dry powder insufflator (Rat AJ DPI) that can emit 68–70 % of the loaded mass for 2 mg and 5 mg of Tobi-EEG powder formulations, achieving a high rat lung deposition efficiency of 79 % and 86 %, respectively. Rat AJ DPI can achieve homogenous distribution of Tobi EEG powder formulations at both loaded mass (2 mg and 5 mg) over all five lung lobes in rats. We then demonstrated that Tobi EEG formulation delivered by Rat AJ DPI can significantly decrease CFU counts in both trachea and lung lobes at 2 mg (p < 0.05) and 5 mg (p < 0.001) loaded mass compared to the untreated P. aeruginosa-infected group. Tobi EEG powder formulation delivered by the novel Rat AJ DPI showed excellent efficiencies in substantially reducing the P. aeruginosa-induced lung infection in rats.

Hyperpolarizing Small Molecules using Parahydrogen and Solid-State Spin Diffusion.

Parahydrogen-induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with polarization levels of >10 % in the solution-state, but is strongly limited in generality since it requires chemical reactions/ interactions with H2. Here we report a new method to widen the scope of PHIP hyperpolarization: a source molecule is produced via PHIP with high 13C polarization, and precipitated out of solution together with a target species. Spin diffusion within the solid carries the polarization onto 13C spins of the target, which can then be dissolved for solution-state applications. We name this method PHIP-SSD (PHIP with solid-state spin diffusion) and demonstrate it using PHIP-polarized [1-13C]-fumarate as the source molecule, to polarize different 13C-labelled target molecules. 13C polarizations of between 0.01 and 3 % were measured on [1-13C]-benzoic acid, depending on the molar ratio of fumarate:benzoate in the solid state. We also show that PHIP-SSD does not require specific co-crystallization conditions by grinding dry powders of target molecules together with solid fumarate crystals, and obtain 13C signal enhancements of between 100 and 200 on [13C,15N2]-urea, [1-13C]-pyruvate, and [1-13C]-benzoic acid. This approach appears to be a promising new strategy for facile hyperpolarization based on PHIP.

Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion

AbstractParahydrogen‐induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with polarization levels of &gt;10 % in the solution‐state, but is strongly limited in generality since it requires chemical reactions/ interactions with H2. Here we report a new method to widen the scope of PHIP hyperpolarization: a source molecule is produced via PHIP with high 13C polarization, and precipitated out of solution together with a target species. Spin diffusion within the solid carries the polarization onto 13C spins of the target, which can then be dissolved for solution‐state applications. We name this method PHIP‐SSD (PHIP with solid‐state spin diffusion) and demonstrate it using PHIP‐polarized [1‐13C]‐fumarate as the source molecule, to polarize different 13C‐labelled target molecules. 13C polarizations of between 0.01 and 3 % were measured on [1‐13C]‐benzoic acid, depending on the molar ratio of fumarate:benzoate in the solid state. We also show that PHIP‐SSD does not require specific co‐crystallization conditions by grinding dry powders of target molecules together with solid fumarate crystals, and obtain 13C signal enhancements of between 100 and 200 on [13C,15N2]‐urea, [1‐13C]‐pyruvate, and [1‐13C]‐benzoic acid. This approach appears to be a promising new strategy for facile hyperpolarization based on PHIP.

Malleable, printable, bondable, and highly conductive MXene/liquid metal plasticine with improved wettability

Integration of functional fillers into liquid metals (LM) induces rheology modification, enabling the free-form shaping of LM at the micrometer scale. However, integrating non-chemically modified low-dimensional materials with LM to form stable and uniform dispersions remain a great challenge. Herein, we propose a solvent-assisted dispersion (SAD) method that utilizes the fragmentation and reintegration of LM in volatile solvents to engulf and disperse fillers. This method successfully integrates MXene uniformly into LM, achieving better internal connectivity than the conventional dry powder mixing (DPM) method. Consequently, the MXene/LM (MLM) coating exhibits high electromagnetic interference (EMI) shielding performance (105 dB at 20 μm, which is 1.6 times that of coatings prepared by DPM). Moreover, the rheological characteristic of MLM render it malleable and facilitates direct printing and adaptation to diverse structures. This study offers a convenient method for assembling LM with low-dimensional materials, paving the way for the development of multifunctional soft devices.

Sustainable valorization of mining waste: Phosphate sludge repurposing for advanced ceramic production

Managing the vast quantities of waste constantly generated by mining activities is one of the major environmental and economic problems facing mankind today. Fluorapatite is separated from the associated gangue minerals by a series of crushing and screening, washing, and flotation processes. These processes produce a significant amount of phosphate sludge, which is stored on the mine site in drift rock and large surface ponds. One possible environmental option is to reuse it as an alternative raw material in ceramics and building materials. Consequently, two phosphate sludges from two different Moroccan towns, Youssoufia and Khouribga, were studied. Due to the complexity of these raw materials resulting from long geological processes, in-depth physical, chemical, mineralogical, and thermal characterization is required. Dry compressed powder pellets were sintered at 900 °C, 1000 °C, and 1100 °C for 2 h. The study focuses on the effect of sintering temperature on mineralogical transformations and ceramic properties such as apparent porosity, water absorption, and mechanical strength. At 1100 °C, a slight increase in density was observed for both phosphate sludges. Water absorption was reduced by 2.51 % in both sludges for pellets sintered at 1100 °C compared to those sintered at 900 °C. Mechanical strength improved significantly, with an increase of about 60 % for samples sintered at 1100 °C, recording 227 N for Youssoufia sludge and 247 N for Khouribga sludge. This work has provided new data on the physical, chemical, mineralogical, and thermal changes in ceramics as the sintering temperature increases. These data will be useful for the manufacture of high-value ceramics.

Exploring the Equilibrium State Diagram of Maltodextrins across Diverse Dextrose Equivalents.

This study investigates the equilibrium state diagram of maltodextrins with varying dextrose equivalents (DE 10 and 30) for quercetin microencapsulation. Using XRD, SEM, and optical microscopy, three transition regions were identified: amorphous (aw 0.07-0.437), semicrystalline (aw 0.437-0.739), and crystalline (aw > 0.739). In the amorphous region, microparticles exhibit a spherical morphology and a fluffy, pale-yellow appearance, with Tg values ranging from 44 to -7 °C. The semicrystalline region shows low-intensity diffraction peaks, merged spherical particles, and agglomerated, intense yellow appearance, with Tg values below 2 °C. The crystalline region is characterized by fully collapsed microstructures and a continuous, solid material with intense yellow color. Optimal storage conditions are within the amorphous region at 25 °C, aw 0.437, and a water content of 1.98 g H2O per g of dry powder. Strict moisture control is required at higher storage temperatures (up to 50 °C) to prevent microstructural changes. This research enhances understanding of maltodextrin behavior across diverse dextrose equivalents, aiding the development of stable microencapsulated products.

Pulmonary administration of cross-linked chitosan nanoparticles of genistein for regulating blood glucose

The research study focused on the development and characterization of sustained release formulation of genistein (GEN)-loaded chitosan (CS) nanoparticles to deliver in the form of dry powder inhaler (DPI) via pulmonary route to offer higher stability and anti-diabetic activity. The GEN-loaded nanoparticles were prepared by cross-linking reaction of CS and sodium hexametaphosphate (SHMP). The optimized formulation displayed particle size (PS) of 684.2 ± 26.5 nm, zeta potential (ZP) of 19.6 ± 4.50 mV, % entrapment efficiency (% EE) of 87.33 ± 8.46 % and drug release profile of 85.48 ± 5.50 % for 48 h. The in-vivo studies exhibited a superior sustained release formulation of GEN in the regulation of blood glucose levels (BGLs). The powder showed the emitted fraction (EF) of 86.76 % and effective inhalation index (EI) of 85.41 %. The reduction of BGLs (85 %) was observed in the diabetic group. This might be due to the inhibition of proliferation of pancreatic β-cells (growth factor inhibition targeting cAMP and ERK1/2 pathway), antioxidative activity, reducing insulin resistance, and the adipose tissue mass and alteration of the hepatic glucose metabolism. Hence, these results proved the delivery of GEN in the form of DPI system as a favorable route for treating type-1 diabetes mellitus with a longer duration of action.

DFT simulated Quercetin imprinted polymer: Selective recovery of Quercetin from onion solid waste

Onion peels (OP) are byproduct of food processing industries that poses economic and environmental challenges. However, being rich source of bioactive compounds like Quercetin (Qt), a polyphenolic antioxidant with potential health benefits, harnessing value from such waste can imbibe sustainable practices and protect environment. With this view, the present study targets selective recovery of Qt from OP waste using rationally designed molecularly imprinted polymer (MIP). Density Functional Theory (DFT) was used for the theoretical selection of the best conformer of Qt (template), methacrylic acid (MAA) as functional monomer, ratio of Qt-MAA for getting stable pre-polymerization complex, and to avoid hit and trial experiments. The theoretical results were validated experimentally by synthesizing MIP/ control polymer (NIP) using MAA as functional monomer, EGDMA as a cross-linker and AIBN as initiator. Synthesized MIP/NIP were characterized using various characterization techniques to confirm successful imprinting. Prepared MIP and NIP could effectively rebind the Qt molecule with binding capacity of 46.67 and 20.89 mg g-1 respectively. Furthermore, synthesized MIP could selectively recover 62.81 % of Qt from 1 g of dry onion peel powder. This study can be effectually used for sustainable recovery of Qt in large scale for various foods, cosmetic and pharmaceutical applications.

In Vitro Evaluation of Colistin Conjugated with Chitosan-Capped Gold Nanoparticles as a Possible Formulation Applied in a Metered-Dose Inhaler.

Inhaled colistin is used to treat pneumonia and respiratory infections through nebulization or dry powder inhalers. Nevertheless, the development of a metered-dose inhaler (MDI) for colistin, which could enhance patient convenience and treatment efficacy, has not yet been developed. Colistin is known for its ability to induce cellular toxicity. Gold nanoparticles (AuNPs) can potentially mitigate colistin toxicity. Therefore, this study aimed to evaluate the antimicrobial effectiveness of colistin conjugated with chitosan-capped gold nanoparticles (Col-CS-AuNPs) and their potential formulation for use with MDIs to deliver the aerosol directly to the deep lung. Fourier-transform infrared spectroscopy, nuclear magnetic resonance, and elemental analysis were used to characterize the synthesized Col-CS-AuNPs. Drug release profiles fitted with the most suitable release kinetic model were evaluated. An MDI formulation containing 100 µg of colistin per puff was prepared. The aerosol properties used to determine the MDI performance included the fine particle fraction, mass median aerodynamic diameter, and geometric standard deviation, which were evaluated using the Andersen Cascade Impactor. The delivered dose uniformity was also determined. The antimicrobial efficacy of the Col-CS-AuNP formulation in the MDI was assessed. The chitosan-capped gold nanoparticles (CS-AuNPs) and Col-CS-AuNPs had particle sizes of 44.34 ± 1.02 and 174.50 ± 4.46 nm, respectively. CS-AuNPs effectively entrapped 76.4% of colistin. Col-CS-AuNPs exhibited an initial burst release of up to 60% colistin within the first 6 h. The release mechanism was accurately described by the Korsmeyer-Peppas model, with an R2 > 0.95. The aerosol properties of the Col-CS-AuNP formulation in the MDI revealed a high fine particle fraction of 61.08%, mass median aerodynamic diameter of 2.34 µm, and geometric standard deviation of 0.21, with a delivered dose uniformity within 75-125% of the labeled claim. The Col-CS-AuNP MDI formulation completely killed Escherichia coli at 5× and 10× minimum inhibitory concentrations after 6 and 12 h of incubation, respectively. The toxicity of CS-AuNP and Col-CS-AuNP MDI formulations in upper and lower respiratory tract cell lines was lower than that of free colistin. The stability of the Col-CS-AuNP MDI formulation was maintained for at least 3 months. The Col-CS-AuNP MDI formulation effectively eradicated bacteria over a 12-h period, showing promise for advancing lung infection treatments.

Biochemical and nutritional analysis of seaweed (Iyengaria stellata) and its therapeutic significance, using antioxidant, antimicrobial, and hypoglycemic activities

Seaweeds have gained significant attention for their bioactive compounds and extensive use in pharmaceuticals, nutraceuticals and cosmeceuticals. Therefore, comprehensive analysis was conducted to investigate the nutritional composition, identify and quantify the Phyco-chemicals and to evaluate the pharmacological potential using hypoglycemic, antimicrobial and antioxidant activities of Iyengaria stellata extract. The results of nutritional analysis revealed 39.72±2.60 % total ash, 14.54±0.44 % crude fat, 9.61±0.60 % proteins, 5.29±0.52 % crude fibers, 10.49±1.00 % moisture content, and total energy was 108.26±2.01 Kcal 100 g−1 of dry powder. Approximately, 15 compounds were tentatively detected in ethyl acetate extract with major compounds being Pentadecanoic acid, 14-methyl-, easter (31.62 %), (Z) -9- stearic acid, methyl easter (13.36 %), Elaidic acid, methyl easter (11.46 %), Phytol (6.31 %), n-Hexadecanoic acid (7.47 %), Linolelaidic acid, methyl ester (5.64 %) and 1-octadecyne (5.34 %). Similarly, n-butanol extract contained 16 compounds with primary compounds being Hexadecanoic acid, methyl ester (25.96 %), Elaidic acid methyl ester (21.39 %), Linolelaidic acid methyl ester (11.53 %), Octadecanoic acid, methyl ester (5.89 %), and Hexanedioic acid, dioctyl ester (5.26 %). FT-IR analysis revealed the presence of similar groups of compounds i.e. alcohols, phenols, lipids, carboxylic acids, amines, aromatics, ketones and halogens. Total phenolic contents (TPC) in ethyl acetate and n-butanol extract were measured as 2.982±0.876 mg GAEg−1 and 1.538±0.711 mg GAE g−1, whereas Total Flavonoids contents (TFC) were 2.058 ± 0.121 mg QE g−1 and 1.614 ± 0.643 mg QE g−1, respectively. Ethyl acetate extract exhibited more antioxidant potential with an IC50 (2.59±1.34) compared to n-butanol extract (2.75±1.60). Moreover, n-butanol extract exhibited strong antimicrobial activity. The most susceptible strains were E. coli, S. aureus and P. aeruginosa. In terms of in-vivo hypoglycemic activity, the n-butanol extract proved to be more effective which significantly reduced the blood glucose level up to 226.17±3.43, 201.33±4.63 and 265.17±3.92 at 300, 200 and 100 mg kg−1 doses respectively after 24 h. In conclusion, the seaweed I. stellata exhibited significant potential in terms of its antioxidant, antimicrobial, and hypoglycemic properties.

Delivery of Inhaled Medication in Children: Revisiting Pharmacological and Practical Issues for Better Health Outcome

For safe and effective therapy of respiratory disorders in children, delivering the medication at the site of disease i.e. directly into the respiratory tract via aerosolized medication is critical. But, the anatomical and physiological differences in the respiratory tract of infants/children and adults make the delivery of aerosolized medication complicated. This review article gives an overview of the delivery of inhaled medication in children and discuss the pharmacological and specific clinically relevant aspects of medication delivery using nebulizers, pressurized metered dose inhalers (MDIs), and dry powder inhalers (DPIs) in children. As a physician, one should always keep in mind the various factors like properties of the device, aerosol particle, patient factors such as disease state, ventilatory pattern, and administration technique that can affect drug deposition via aerosol delivery devices.

Cryomilled electrospun nanofiber mats containing d-mannitol exhibit suitable for aerosol delivery of proteins

Dry powder inhalers (DPIs) are the first choice for inhalation drug development. However, some conventional DPI formulation processes require heating, which may damage high molecular weight drugs such as proteins and nucleic acids. In this study, we propose a novel DPI preparation process that avoids the use of heat. Dry powders were prepared by cryomilling nanofiber mats composed of polyvinyl alcohol, D(−)-mannitol (Man), and α-chymotrypsin (α-Chy) as the model drug using the electrospinning method. The addition of Man conferred high dispersibility and excellent in vitro aerosol performance to the nanofiber mat powder in a very short milling time (less than 0.5 min) as assessed using the Andersen cascade impactor. Powders were classified according to the degree of friability, and among these, nanofiber mats containing 15 % Man and milled for 0.25 min exhibited the highest aerosol performance. Nanofiber mats containing Man milled for less than 0.5 min also exhibited greater α-Chy enzymatic activity than a nebulized α-Chy solution. Furthermore, single inhalation induced no significant lung tissue damage as evidenced by lactate dehydrogenase activity assays of mouse bronchoalveolar lavage fluid. This novel DPI formulation process may facilitate the safe and efficient inhalational delivery of therapeutic proteins.

A Novel Inhalable Dry Powder to Trigger Delivery of Voriconazole for Effective Management of Pulmonary Aspergillosis.

Invasive pulmonary aspergillosis (IPA) is a fatal fungal infection with a high mortality rate. Voriconazole (VCZ) is considered a first-line therapy for IPA and shows efficacy in patients for whom other antifungal treatments have been unsuccessful. The objective of this study was to develop a high-potency VCZ-loaded liposomal system in the form of a dry-powder inhaler (DPI) using the spray-drying technique to convert liposomes into a nanocomposite microparticle (NCMP) DPI, formulated using a thin-film hydration technique. The physicochemical properties, including size, morphology, entrapment efficiency, and loading efficiency, of the formulated liposomes were evaluated. The NCMPs were then examined to determine their drug content, production yield, and aerodynamic size. The L3NCMP was formulated using a 1:1 lipid/L-leucine ratio and was selected for in vitro studies of cell viability, antifungal activity, and stability. These formulated inhalable particles offer a promising approach to the effective management of IPA.

FT-IR-based fingerprint combined with unsupervised chemometric analysis revealed particle sizes and aqueous-ethanol ratio alter the chemical composition and nutraceutical value of Daucus carota

This study reported the effects of particle size of dry powder and the optimum solvent extraction on the nutraceutical value of carrot by observing its FT-IR fingerprint, TPC, TFC, and antioxidant activity. The dried-powdered carrot was ultrasound-assisted extracted using EtOH, water, and EtOH-water. The TFC, TPC, and antioxidant activity were analysed by a colorimetric method using a spectrophotometry UV-Vis. The chemotaxonomy of samples was analysed using FT-IR combined with chemometrics analysis. The TFC, TPC, and antioxidant capacity were significantly different for each sample with the highest TFC, TPC, and antioxidant obtained on particle size 149 μm with EtOH-water (50:50) as the most prominent solvent (19.51 mgQE/g, 9.90 mgGAE/g, IC50: 16.7 ± 0.89 µg/mL). FT-IR profiling of samples also illustrates a minor different pattern of the spectrum, indicating there is a difference in their chemical composition. The particle size and EtOH-water ratio influence the chemical composition and antioxidant activity of carrots.

Evaluating the effect of sodium alginate and sodium carboxymethylcellulose on pulmonary delivery of levofloxacin spray-dried microparticles.

Patients with cystic fibrosis commonly suffer from lung infections caused by Pseudomonas aeruginosa. Recently, the Levofloxacin (LVF) nebulizing solution (Quinsair®) has been prescribed for the antimicrobial management. The sustained-release (SR) dry powder formulation of LVF is a convenient alternative to Quinsair®. It has the potential to enhance patient convenience and decrease the likelihood of drug resistance over time. In this paper, we set forth to formulate and evaluate the potential application of sodium alginate (SA) and sodium carboxymethylcellulose (SCMC) for sustained pulmonary delivery of LVF. The spray-dried (SD) LVF microparticles were formulated using SCMC and SA along with L-leucine (Leu). The microparticles were analyzed in terms of particle size, morphology, x-ray diffraction (XRD), in-vitro drug release, and aerodynamic properties. Selected formulations were further proceeded to short-term stability test. The polymer-containing samples displayed process yield of 33.31%-39.67%, mean entrapment efficiency of 89% and volume size within the range of 2-5 μm. All the hydrogel microparticles were amorphous and exhibited rounded morphology with surface indentations. Formulations with a drug-to-excipient ratio of 50:50 and higher, showed a 24-h SR. The aerodynamic parameters were fine particle fraction and emitted dose percentage ranging between 46.21%-60.6% and 66.67%-87.75%, respectively. The short-term stability test revealed that the formulation with a 50:50 drug-to-excipient ratio, containing SA, demonstrated better physical stability. The selected formulation containing SA has the potential to extend the release duration. However, further enhancements are required to optimize its performance.

Inhalable Polymeric Microparticles for Phage and Photothermal Synergistic Therapy of Methicillin-Resistant Staphylococcus aureus Pneumonia.

Acute methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is a common and serious lung infection with high morbidity and mortality rates. Due to the increasing antibiotic resistance, toxicity, and pathogenicity of MRSA, there is an urgent need to explore effective antibacterial strategies. In this study, we developed a dry powder inhalable formulation which is composed of porous microspheres prepared from poly(lactic-co-glycolic acid) (PLGA), internally loaded with indocyanine green (ICG)-modified, heat-resistant phages that we screened for their high efficacy against MRSA. This formulation can deliver therapeutic doses of ICG-modified active phages to the deep lung tissue infection sites, avoiding rapid clearance by alveolar macrophages. Combined with the synergistic treatment of phage therapy and photothermal therapy, the formulation demonstrates potent bactericidal effects in acute MRSA pneumonia. With its long-term stability at room temperature and inhalable characteristics, this formulation has the potential to be a promising drug for the clinical treatment of MRSA pneumonia.

Wet Tissue Interfacial Water Triggers Ultrafast In Situ Gelation of Sprayable Dry Powder for Postoperative Anti‐Adhesion

AbstractPostoperative adhesions complicate the majority of surgical procedures, imposing an excess medical burden. The segregation of injured tissue from healthy tissue is considered the optimal therapeutic strategy. However, achieving hemostasis while preventing adhesions in the immediate postoperative setting continues to pose a significant challenge. This paper presents the in situ formation of an asymmetrically adhesive hydrogel barrier via a sprayable dry powder (SDP) that enables interfacial water‐induced, ultra‐rapid gelation. Owing to SDP hydrophilicity and the interstitial spaces between particles, it can rapidly and efficiently absorb interfacial water, thereby facilitating smooth cross‐linking between material functional groups and tissue functional groups. In addition, SDP becomes less adhesive after gelation as a layer of interfacial water forms on the surface of the SDP hydrogel, enhancing its anti‐adhesion properties. Animal experiment outcomes demonstrate that SDP exhibits significant asymmetric adhesive properties before and after gelation, successfully preventing postoperative adhesions. As a result, SDP heralds a novel approach to the development of adhesives that can simultaneously mitigate adhesions and promptly arrest bleeding.

Study of the Effect of Hexane Extracts and Dry Powder of Ocimum Leaves and Flowers on the Percentage of Mortality of Adult Southern Cowpea Beetle Callosobruchus maculatus

Study of the Effect of Hexane Extracts and Dry Powder of Ocimum Leaves and Flowers on the Percentage of Mortality of Adult Southern Cowpea Beetle Callosobruchus maculatus

Influence of In-Process Emulsion Size on the Stability of PFH-VAP, a Stable Vitamin A Palmitate Dry Powder Formulation Developed for Use in Food Fortification

Influence of In-Process Emulsion Size on the Stability of PFH-VAP, a Stable Vitamin A Palmitate Dry Powder Formulation Developed for Use in Food Fortification

PELATIHAN ALAT PEMADAM API RINGAN DAN KARUNG GONI SEBAGAI MEDIA PEMADAMAN KEBAKARAN KEPADA MAHASISWA POLIBATAM, SISWA DAN GURU SMK DI BATAM

Fire disaster is one of the many disasters that occur in the wider community both in the office and residential environment. This fire disaster generally occurs due to human factors such as: using electrical loads that exceed the power capacity and placing flammable items near the source of fire. This fire hazard will be easier to overcome if people know how to put out fires properly and know how to use extinguishers such as APAR (Light Fire Extinguisher) and the use of gunny sacks. APAR is generally categorized into 3 types, namely: Dry Chemical Extinguisher, Carbon Dioxide (CO2) Extinguisher, and Foam. Extinguishers containing dry chemical powder are very commonly used because they are able to extinguish almost all types of fires. The use of APAR is most likely to be used because of its portable nature, easy maintenance, and easy to use. In the community service that has been carried out at Batam State Polytechnic, a demonstration on how to extinguish fire with fire extinguisher and the use of gunny sacks was also carried out. Participants of this community service program are students, vocational school students and vocational school teachers.