The Fe35Ni35Cr20Mn10 high-entropy alloy wires can achieve a large strain of 8.73 and a section reduction ratio of 99.98 %,and possess a high strength of 1868 MPa via traditional wire drawing. The microstructure evolution and mechanical properties of cold-drawn Fe35Ni35Cr20Mn10 high-entropy alloy are characterized by microstructure observation and tensile test. The results showed that The Fe35Ni35Cr20Mn10 HEA has excellent plastic forming capacity and excellent phase stability during plastic deformation. The Fe35Ni35Cr20Mn10 HEA has excellent continuous drawing ability, the main deformation mechanism is the plane slip and cross slip of the dislocation and the dynamic recovery of the sublamellar layer make the lamellar structure maintain a dynamic equilibrium state, and the lamellar thickness is basically unchanged to support the continuous plastic deformation under high strain conditions. The dynamic balance of coarsening and refining of lamellar structure in the process of plastic deformation is mainly due to the merging of HEA lamellar caused by the movement of trigeminal node induced by strain. Texture evolution showed that the <111> and <100> fiber textures were the stable texture component and the texture component content remained unchanged even under further increased strain. The Fe35Ni35Cr20Mn10 high-entropy alloy wire with high strain of 8.73 possesses excellent strength, and its tensile strength is 1868 MPa at room temperature, which has the largest strain. The dislocations proliferation, lamellar structure refinement and texture strengthening lead to high strength of the Fe35Ni35Cr20Mn10 high-entropy alloy wire.