Porous asphalt mixtures are gaining popularity due to their ability to effectively drain surface water and mitigate traffic noise in regions with high rainfall. However, compared to conventional asphalt pavements, these types of pavements with high void content necessitate specific guidelines for achieving an optimal mix design. The performance characteristics of porous asphalt mixtures are notably influenced by the grading and composition of materials, especially with regards to their resistance to moisture damage. This study aimed to investigate the properties of porous asphalt mixtures using limestone and siliceous aggregates with varying gradations, while maintaining bitumen contents of 5% and 6%. In accordance with the regulations set forth by the National Center for Asphalt Technology, the findings indicate that siliceous-based aggregates exhibit improved void characteristics (increased by 3%) and permeability (increased by 11%). However, they also display reduced resistance to moisture-induced failures (decreased by 4%). On the other hand, adhering to the gradation recommendations provided by the National Asphalt Pavement Association guidelines, except for a slight decrease of 3% in moisture sensitivity, yields an overall enhancement of 25% in other performance characteristics. To analyze the data, statistical methods were employed, resulting in regression models with a minimum R2 value of 0.97. These models helped determine the optimal binder percentage for different aggregate types and gradations, providing valuable insights for practical implementation.