Because of their long submerged columns, deep-draft semi-submersible floating structures are particularly susceptible to vortex-induced motions. This paper focuses on the steady and unsteady forces that act on such a column pair, as well as on the frequency and strength of the shed vortices behind the downstream column. Wind tunnel experiments were performed on two rounded and lightly rough square-section prisms in cross-flow for Reynolds numbers from 100,000 up to 7 million. They are arranged inline at centre-to-centre distances of S/D = 2.8, 4, and 5.6 and at 0° or 45° incidence angle. The trend of the drag curve for the upstream prism deviates at S/D = 2.8 and 4 sharply from that for a single prism. The drag force on the downstream prism strongly depends on both S/D and α. At S/D = 2.8, a thrust force occurs either in certain (α = 0°) or in all (α = 45°) flow states. Larger spacing values lead to an overall higher drag and a flattening of the Cd2 (ReD) curve. The highest fluctuating lift forces on the downstream prism are obtained at α = 45°. Regarding the vortex shedding frequency, differences between both incidence angles occur at S/D = 5.6 only.