The vortex-induced vibrations (VIV) of two flexible circular cylinders in tandem arrangements were studied using numerical simulations and verified by experimental data. Simulations were conducted for a constant mass ratio of 1.08, the spacing ranges of 6D to 18D, and the reduced velocities of 2.35–6.71. It is shown that the numerical results are in a good agreement with the experimental data of the amplitude and frequency of response. The features of the vibration amplitude, the dominant frequencies, the vortex structures and the fluid force acting on the cylinders are discussed. The results indicate that there is a great difference between the response of the upstream cylinder and that of the downstream cylinder. When the reduced velocity is beyond the critical reduced velocity Vr*, the dominant frequencies of the upstream cylinder and the downstream cylinder are no longer the same. And both the reduced velocity and the spacing of the cylinders have a great influence on the wake-induced vibrations (WIV) responses of the downstream cylinder. Considering these influences, an empirical model for WIV frequency response of the downstream cylinder with a low mass ratio was proposed and verified.