The article presents the results of changes in the fertility of meadow-brown bleached soil in a long-term stationary experiment, laid down in 1941. It has been established that applying various systems of manure, lime, and mineral fertilizers in a single and double dose for 79 years improves the agrochemical soil properties. The content of organic matter in the variants of the manure-lime-mineral system with single and double doses of mineral fertilizers increased from 3.00% (control) to 3.11 and 3.21%, respectively. The phosphate regime of the soil improved when manure and lime were used together with mineral fertilizers in a doubled rate up to 137 mg/kg, and against liming with a single dose of mineral fertilizers up to 76 mg/kg, in the control variant - 15 mg/kg. Under the influence of lime and single norms of mineral fertilizers for wheat, the soil solution is deoxidized to a neutral value of 6.1, in the control variant without fertilizers the soil is subacid - 5.1. In the variant with the use of only double doses of mineral fertilizers, an increased yield of 4.8 t/ha and protein content of 13.8% in spring wheat was noted, in the control - 4.3 t/ha and 12.4%, respectively. The analysis of the correlation dependence of yield and protein per grain with a complex agrochemical property showed a strong direct relationship - r = 0.91; 0.78 respectively.