Introduction: Post-ERCP pancreatitis (PEP) is one of the most feared and most common complications of an ERCP, with an incidence of approximately 9.7%. While several risk factors for PEP have been established, the relationship between post-procedure diet and PEP is not well understood. We sought to evaluate whether a regular diet immediately post-ERCP was associated with an increase in PEP. Methods: This was a retrospective study during which consecutive patients at two academic medical centers who underwent ERCP in 2021 were evaluated. Inclusion criteria were a) patients ≥ 18 years old; b) inpatient status prior to ERCP; c) no prior history of ERCP; d) no prior history of pancreatitis; e) no prior history of Sphincter of Oddi dysfunction. Data collected from these patients included patient demographics, ERCP procedure details, pre- and post- ERCP diet orders, and post- procedure complications. Association with PEP was evaluated using X2 and Fisher’s exact tests. Results: 100 consecutive patients met inclusion criteria and were included in this study. Overall, 74 patients (74%) received a modified post-ERCP diet, and 26 (26%) of patients received a regular post-ERCP diet. There was no significant difference in the incidence of PEP between these two groups (7/74 (9.4%) vs 0/26 (0%), p = 0.185). Cannulation type was found to be significantly associated with the development of PEP (standard cannulation, 2/72 (2.7%) vs other cannulation (double wire, needle knife, sphincteroplasty- assisted), 5/25 (20%), p=0.011). No other factors were found to have a significant association with the development of PEP (Table). Conclusion: In this cohort of 100 patients, post-ERCP diet choice was not found to be associated with the development of PEP. In fact, the only factor that was associated with PEP was a non-standard cannulation during ERCP, which is a well-established risk factor. The lack of association of post ERCP diet with PEP is an important finding because it is a common practice for endoscopists to recommend a modified consistency diet post ERCP to reduce the risk of PEP despite the lack of supporting evidence for this recommendation. Immediate advancement to a regular diet has significant benefits including aiding in patient recovery, reducing hospital length of stay, and improving patient satisfaction. Larger scale studies to corroborate this data in a prospective fashion are indicated. Table 1. - Factors Associated with the Development of Post-ERCP Pancreatitis Post-ERCP Pancreatitis Yes No p-value Main Exposure: Post-ERCP Diet, n (%) 0.1852 Modified 7 (9.46) 67 (90.54) Regular 0 26 (100.00) Demographic Characteristics Sex, n (%): 1.0000 Male 4 (7.27) 51 (92.73) Female 3 (6.67) 42 (3.33) Age in Years: 0.5122 Mean (SD) 58.29 (21.69) 63.46 (18.46) Comorbidities History of Pancreatitis, n (%) 1.0000 Yes 0 (0.00) 10 (100.00) No 7 (7.78) 83 (92.22) History of Cholelithiasis, n (%) 0.3411 Yes 0 (0.00) 19 (100.00) No 7 (8.64) 74 (91.36) ERCP Characteristics Indication, n (%) 0.8308 Benign Bile Duct Pathology 6 (8.45) 65 (91.55) Malignancy 1 (6.25) 15 (93.75) Benign Pancreas Duct Pathology 0 (0.00) 13 (100.00) Cannulation Type (N = 97*), n (%) 0.0116 Standard 2 (2.78) 70 (97.22) Other 5 (20.00) 20 (80.00) Sphincterotomy, n (%) 0.1856 Yes 4 (5.06) 75 (94.94) No 3 (14.29) 18 (85.71) Biliary Stent, n (%) 0.1139 Yes 6 (11.54) 46 (88.46) No 1 (2.08) 47 (97.92) Pancreatic Stent, n (%) 0.3108 Yes 2 (12.50) 14 (87.50) No 5 (5.95) 79 (94.05) Complexity Grade, n (%) 1.0000 Grade 3 1 (7.69) 12 (92.31) Grade 1-2 6 (6.90) 81 (93.10) Post-Procedure Fluid (mL, N = 81*), n (%) 0.9525 Mean (SD) 870.00 (710.28) 904.45 (778.64) Rectal Indomethacin Given, n (%) 0.1037 Yes 7 (9.86) 64 (90.14) No 0 (0.00) 29 (100.00) *N listed due to missing data for some patients at these data points