Double Time Research Articles

Sarah Morgan Bryan Piatt and the Double Time of Motherhood

Sarah Morgan Bryan Piatt and the Double Time of Motherhood

Vibrations on mastoid process alter the gait characteristics during walking on different inclines.

Eighty-eight percent of the persons with bilateral vestibular dysfunction have reported at least one fall within the past 5 years. The apparent alternations due to the bilateral vestibular dysfunctions (BVD) are the gait characteristics, such as slower walking speed, prolonged stance phase, and shorter step length. Unexpectedly, due to the prevalence of this BVD being relatively low, attention is not obtained as same as in other vestibular disorders. Moreover, how does walking on different inclines, part of daily activities, alter the gait characteristics under the unreliable bilateral vestibular systems? Previous studies used vibration-based stimulations (VS) as a perturbation to understand the postural control during walking while the bilateral vestibular systems were perturbed. Therefore, this study attempted to extend the knowledge to understand the alternations in spatial-temporal gait characteristics under perturbed bilateral vestibular systems while walking on different inclines. Nineteen healthy young adults participated in this study. Eight walking conditions were randomly assigned to each participant: 0%, 3%, 6%, and 9% grade of inclines with/without VS. The preferred walking speed was used for gait analysis. The dependent variables were stance time, double support time, step length, step time, step width, foot clearance, and respective variabilities. All dependent variables were defined by two critical gait events: heel-strike and toe-off. Pre-Hoc paired comparisons with Bonferroni corrections were used to prioritize the dependent variables. A two-way repeated measure was used to investigate the effect of VS and the effect of inclines on the selected dependent variables from Pre-Hoc analysis. Post-Hoc comparisons were also corrected by the Bonferroni method. The step length, step time, foot clearance, and foot clearance variability were selected by the Pre-Hoc analysis because the corrected paired t-test demonstrated a significant VS effect (p < 0.05) on these gait parameters at least one of four inclines. The significant interaction between the effect of VS and the effect of inclines was found in step length (p = 0.005), step time (p = 0.028), and foot clearance variability (p = 0.003). The results revealed that implementing a VS increased step length and step time when walking on 0%, 3%, and 9% of grade inclines. In particular, the foot clearance variability was found when walking on 9% of grade inclines. The observations in the current study suggested that VS increased the step length, step time, foot clearance, and foot clearance variability while walking on inclines. These results suggested that these gait parameters might be promising targets for future clinical investigations in patients with BVD while walking on different inclines. Importantly, the increases in spatial-temporal gait performance under bilateral VS might be an indicator of gait improvement while walking on different inclines.

Effects of Incorporating Double Time Delays in an Investment Savings-Liquidity Preference Money Supply (IS-LM) Model

The Investment Savings-Liquidity preference Money supply (IS-LM) model is represented as a graph depicting the intersection of products and the money market. It elaborates how an equilibrium of money supply versus interest rates may keep the economy in control. In this paper, we combine the basic business cycle IS-LM model with Kaldor’s growth model in order to create an augmented model. The IS-LM model, when coupled with a certain economics expansion (in our instance, the Kaldor–Kalecki Business Cycle Model), provides a comprehensive description of a developing but robust economy. Right after the introduction of capital stock into the system, it cannot be employed and also, while making some investment choices, this requires some time in execution, which ultimately alters resources, i.e. capital. Thus, in the capital accumulation, we will be incorporating double time delays in Gross product and Capital Stock. These time delays represent the time periods during which investment decisions were made and executed and the time spent in order for the capital to be put to productive use. After formulating a mathematical model using delayed differential equations, dynamic functioning of the system around equilibrium point is examined where three instances appeared based on time delays. These cases are: when both delays are not in action, when only one delay is in action and when both delays are in action. It is shown that time delay affects the stability of the equilibrium point and, as the delay crosses a critical point, Hopf bifurcation exists. It is observed that by using Kaldor type investment function, the delay residing in capital stock only will destabilize in less time as compared to when both the delays are present in the system. The system is sensitive to certain parameters which is also analyzed in this work.

Visual and circadian regulation of Drosophila BDBT and BDBT effects on DBT and PER localization

BRIDE OF DOUBLETIME (BDBT) interacts with the circadian kinase DOUBLETIME (DBT) and accumulates in eye foci during the dark of a light:dark cycle. BDBT foci are shown here to be broadly expressed in constant dark and low in constant light. Analysis of circadian photoreceptor cry and visual photoreceptor ninaE mutantsshowed that disappearance of eye BDBT foci requires both the CRYPTOCHROME and the RHODOPSIN-1 pathways. The arr1 and arr2 mutants, which affect rhodopsin quenching, eliminated BDBT foci under dark conditions. arr1 and arr2 mutants also caused increased nuclear PER protein. The changesin BDBT foci do not result from altered BDBT levels in the eye but from changes in its immunodetection. Knockdown of BDBT specifically in theeye produced constitutively nuclear PER and constitutively cytosolic DBT. The results show that BDBT is necessary for co-transport of DBT and PER into the nucleus and suggest that this process is regulated by a light-dependent mechanism.

Consistent Design of PID Controllers for an Autopilot

Abstract A consistent approach to the development of tuning rules for course-keeping and path-tracking PID controllers for a ship autopilot are presented. The consistency comes from the observation that for each of the controllers the controlled plant can be modelled by an integrator with inertia. In the case of the course controller, it is the well-known Nomoto model. The PID controller may be implemented in series or parallel form, the consequence of which is a 2nd or 3rd order of the system, specified by a double or triple closed-loop time constant. The new tuning rules may be an alternative to the standard ones given in [1,2]. It is shown that, whereas the reference responses for the standard and new rules are almost the same, the new rules provide better suppression of disturbances such as wind, waves or current. The parallel controller is particularly advantageous. The path-tracking PID controller can provide better tracking accuracy than the conventional PI. Simulated path-tracking trajectories generated by a cascade control system are presented. The novelty of this research is in the theory, specifically in the development of new tuning rules for the two PID autopilot controllers that improve disturbance suppression.

Jednolite projektowanie regulatorów kursu i ścieżki dla autopilota statku

Uniform approach to selection of PID settings for heading and path tracking controllers that create a cascade control system for ship autopilot is presented. Uniformity of the design follows from observation that for each of the controllers the controlled plant looks like an integrator with time constant. In case of the heading controller, the plant is represented by the known Nomoto model. Due to elimination of the plant time constant by the controller, each of the closed loop systems becomes of 2nd order. One assumes that such system should have a double time constant, different in a prescribed ratio from time constant of the controlled plant. It is shown that the heading controller designed in this way suppresses disturbances better than the controller with standard settings.

Maximal aerobic and anaerobic power and time performance in 800 m double poling ergometer

The purpose of this study was to investigate to what extent aerobic power (MAP), maximal anaerobic power (MANP), anaerobic capacity measured as time to exhaustion at 130% MAP (TTE), and maximal accumulated oxygen deficit (MAOD) correlated with 800 m double poling time trial performance (800TT) in a ski ergometer. A second aim was to investigate the relationship between TTE and MAOD, and to what extent TTE and MAOD would relate to anaerobic power reserve (APR). Eighteen cross-country skiers were tested for peak oxygen uptake (VO2peak) and oxygen cost of double poling to assess MAP. Peak power measurements during a 100 m TT were performed to assess MANP. TTE and an 800TT with continuous VO2 measurements were performed to assess time performance and MAOD. All tests were performed on a ski ergometer. Both MAP and MANP correlated strongly (r = − 0.936 and − 0.922, respectively, p < 0.01) with 800TT. Neither TTE nor MAOD correlated with 800TT. TTE correlated moderately with MAOD, both in mL kg−1 and in %VO2peak (r = 0.559, p < 0.05 and 0.621, p < 0.01, respectively). Both TTE and MAOD seemed to be a product of APR. These results suggest focusing on MAP and MANP, but not anaerobic capacity to explain time performance in an event with approximately 3 min duration.

Acclimatization of force production during walking in persons with Parkinson's disease

Individuals with Parkinson’s disease walk slowly, with short strides resulting in decreased mobility. Treadmill walking assessments are utilized to understand gait impairment in persons with Parkinson’s disease and treadmill-based interventions to mobility have become increasingly popular. While walking on a treadmill, there is a reported initial acclimatization period where individuals adjust to the speed and dynamics of the moving belt before producing consistent walking patterns. It is unknown how much walking time is required for individuals with Parkinson’s disease to acclimate to the treadmill. We investigated how spatiotemporal parameters and ground reaction forces changed during treadmill acclimatization. Twenty individuals with idiopathic Parkinson’s (15 Males, 5 Females) walked for a five-minute treadmill session on an instrumented treadmill while motion capture data were collected. The measures of interest included ground reaction force measures (peak propulsive force, peak braking force, propulsive impulse, and braking impulse) and spatiotemporal measures (stride length, stride time, or double support time). Analyses demonstrated significantly increased propulsive impulse (p <.001) after the first minute, with no significant difference for the remaining minutes (p ≥ 0.395). There were no significant changes in the spatiotemporal measures (P =.065). These results quantify the stabilization of ground reaction force during the treadmill acclimatization period. Based on our findings, if steady-state gait is desired, we recommend participants walk for at least two minutes before data collection. Future clinical investigations should consider ground reaction force as sensitive parameters for evaluating gait in persons with Parkinson’s disease in treadmill-based assessments or interventional therapies.

Does GERAS DANCE improve gait in older adults?

BackgroundOlder adults at increased fall risk walk slower with less rhythm and coordination. This study explored the effect of dance on spatiotemporal gait parameters in older adults. MethodsParticipants (N = 23) in a single-arm trial were enrolled in the 12-week GERAS DANCE program (total dose of 36 h). Gait was assessed at baseline and 12-weeks under two experimental conditions: normal walking or walking while performing serial subtraction by 3. Outcome measures were gait speed, stride length time, double support time, stride length and stride width. Separate two-way repeated measures ANOVAs were used to determine estimates of the magnitude of effect of GERAS DANCE on spatiotemporal gait parameters and a paired t-test was used to examine differences in cognitive performance before and after dance. ResultsOlder adults (72.50 ± 7.13 years; 75% female) had excellent attendance (82.73% adherence). GERAS DANCE resulted in increased gait speed (p<0.001), reduced stride length time (p = 0.034), reduced double support time (p = 0.001), increased stride length (p = 0.003) and marginally reduced stride width (p = 0.064), regardless of the experimental condition. Improvements in walking performance were observed with sustained performance on the serial subtraction task before and after GERAS DANCE. ConclusionsGERAS DANCE may be a safe and feasible program to help improve spatiotemporal gait parameters in older adults with early memory or mobility impairments. Next steps include testing the efficacy for fall prevention to help inform clinical practice guidelines and virtual intervention implementation.

Simulation-Based Optimization of Transport Efficiency of an Urban Rail Transit Network

It has been proven that developing urban rail transit (URT) is the key to solving the traffic problems in big cities, and transport efficiency is essential for scientific line planning and construction, operation management and sustainable development of urban rail transit. This paper focuses on the transport efficiency of the URT network and adopts shadow efficiency theory creatively to combine factors of passengers, capacity, and efficiency effectively. A quantitative calculation method of system utility based on “double time penalty” is proposed. According to the characteristics of Beijing URT, this paper puts forward a single optimization strategy and combinatorial optimization strategy and analyzes the results with DEA. The simulation of Beijing subway network proves the availability of the method and its optimization effects.

Validation of an Ear-Worn Wearable Gait Analysis Device.

Wearable devices capable of measuring gait parameters may provide a means to more economical gait analysis compared to conventional equipment comprising of a motion capture system and a forced treadmill. Beflex Coach (Beflex, Republic of Korea) is one such device but worn on the ear as Bluetooth earphones, unlike other wearables worn on the wrist, feet, or torso. In this study, the validity of the device was examined against a motion capture system and a forced treadmill for walking and running parameters. Five walking parameters (cadence, single support time, double support time, vertical oscillation (VO), and instantaneous vertical loading rate (IVLR)) and six running parameters (cadence, stance time, flight time, peak force, VO, and IVLR) were studied. Twenty young adults participated in walking or running on a forced treadmill at different speeds (walking: 0.8, 1.25, and 1.7 m/s for walking; running: 2, 2.5, and 3 m/s) while the two systems operated simultaneously. As a result, all parameters showed excellent associations (ICC > 0.75) and good agreements in Bland-Altman plots. The results of the study support the potential use of the ear-worn device as an inexpensive gait analysis equipment.

The effect of complex decongestive therapy on spatio-temporal parameters and balance in women with breast cancer-related upper extremity unilateral lymphedema

BackgroundThe aim of this study was to investigate the effect of complex decongestive therapy on spatio-temporal parameters and balance in individuals with breast cancer-related upper extremity unilateral lymphedema. MethodsThe study was designed as a prospective, cross-sectional study. Thirty sessions of complex decongestive therapy were applied. Participants' pre-and post-treatment spatio-temporal parameters and balance parameters were evaluated with the Win Track platform. In addition, the Timed Up and Go test was used to evaluate the dynamic balance. Plethysmography, a water displacement method, was used to measure upper extremity volume. FindingsSignificant improvement was observed in limb volume asymmetry after complex decongestive therapy. While the stride length of the affected side was 409.93 mm before the treatment, it increased to 500.93 mm after the treatment, and a significant increase was observed (p = 001). Significant improvements were found in the other spatio-temporal parameters of the participants. Compared to the pre-treatment, a significant decrease was detected in the average cadence value, Timed Up and Go value, double stance time, and maximum plantar pressure point of the participants. Significant improvements were found in the participants' balance. InterpretationComplex decongestive therapy applied to individuals with unilateral upper extremity lymphedema provides significant improvement in both spatio-temporal and balance parameters. However, we recommend complex decongestive therapy as an effective and safe treatment to reduce the volume of lymphedema. Patients with unilateral lymphedema that may cause postural asymmetry should be informed about balance and gait disturbance and should be encouraged to receive lymphedema treatment as soon as possible.

Phosphorylation Promotes the Accumulation of PERIOD Protein Foci.

Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes. A very recent study reported that the clock protein PERIOD (PER) is organized into discrete foci at the nuclear envelope in fly circadian neurons, which is believed to be important for controlling the subcellular localization of clock genes. Loss of inner nuclear membrane protein lamin B receptor (LBR) leads to disruption of these foci, but how they are regulated is yet unknown. Here, we found that PER foci are likely phase-separated condensates, the formation of which is mediated by intrinsically disordered region in PER. Phosphorylation promotes the accumulation of these foci. Protein phosphatase 2A, which is known to dephosphorylate PER, hampers the accumulation of the foci. On the other hand, the circadian kinase DOUBLETIME (DBT) which phosphorylates PER enhances the accumulation of the foci. LBR likely facilitates PER foci accumulation by destabilizing the catalytic subunit of protein phosphatase 2A, MICROTUBULE STAR (MTS). In conclusion, here, we demonstrate a key role for phosphorylation in promoting the accumulation of PER foci, while LBR modulates this process by impinging on the circadian phosphatase MTS.

Effect of Medication and Deep Brain Stimulation on Gait in Parkinson's Disease and its Quantitative Analysis Using Mobishoe - A Comparative Study.

Movement abnormalities pertaining to balance, posture, and gait are observed in Parkinson's disease patients. Gait characteristics vary widely and their analysis has been performed traditionally in gait labs. Freezing and festination usually occur at an advanced stage of the disease and are associated with reduced quality of life. Therapeutic strategies and surgical interventions are often modulated by the physician depending upon the clinical manifestations. Introduction of accelerometers and wireless data transmission systems made quantitative gait analysis possible and cost-effective. To assess spatiotemporal gait parameters (step height, length (spatial), and swing support time of each foot and double support time (temporal)) in subjects who underwent deep brain stimulation surgery using a purpose-built instrument-Mobishoe. A simple footwear-based gait sensing device-Mobishoe was built in-house. Thirty-six participants were included in the study after obtaining consent. Participants were made to wear Mobishoe and walk an empty corridor of 30m before Deep Brain Stimulation (DBS) in the drug on and off stated and post DBS in DBS stimulation on and medication off state (B1M0), DBS stimulation off-medication off state (B0M0), DBS stimulation off-medication on (B0M1), and DBS stimulation on and on medication (B1M1). Data was electronically captured and analyzed offline in MATrix LABoratory (MATLAB). Various gait parameters were extracted and analyzed. Improvement in gait parameters was observed when the subject was on medication, on stimulation, or on both when compared to baseline. Improvement was similar with both medication and stimulation and was synergistic when both were used. Significant improvement was noted in spatial characteristics when the subjects were on both the treatments, which is the ideal treatment modality. Mobishoe is an affordable device which can measure spatiotemporal characteristics of gait. The best improvement was seen when the subjects were on both the treatment groups and the improvement can be justified as a synergistic effect of stimulation and medication.

Role of anharmonicity in the phonon density of states of high temperature superconductors

Owing to the quantum dynamical approach of double time temperature dependent phonon-Green’s functions, the expression for phonon density of states (PDOS) has been developed via an almost complete Hamiltonian which consists of the contributions due to the unperturbed phonons and electrons, anharmonic phonon fields, localized phonon fields and that of electron–phonon interactions. It has been observed that the anhrmonicity play an vital role in the PDOS through energy line width. Enhancement in the PDOS due to electron–phonon interactions has been mainly discussed in this work, which, in turns, will be capable to explain a large number of dynamical properties of crystals even that of superconductors. The temperature dependence of PDOS has been found as a unique feature of the theory, which certainly becomes the outcome of the anharmonic interactions. The presence of electron–phonon interaction parameters in each term is an additional and new feature of the theory.

Substitutional Effect on Dielectric Losses in Polycrystalline CaxSr1-xTiO3 and PbxSr1-xTiO3 Ferro-Electric Mixed Crystals

Abstract: The Dielectric losses are theoretical investigated for CaxSr1-xTiO3 and PbxSr1-xTiO3 single crystal perovskites in paraelectric phase as a function of composition and temperature. In our calculation, the Silverman Joseph`s Hamiltonian augmented with fourth order phonon co-ordinates using double time temperature dependent Green`s Function technique is used. Dielectric loss is estimated for various value of x. The substitutional impurity depend dielectric losses increases with increases in composition x at room temperature and Dielectric loss tangent (tan δ) increases with increasing temperature at constant values of x.

ASSOCIATIONS OF GAIT CHARACTERISTICS AND VARIABILITY WITH WALKING EFFICIENCY IN OLDER ADULTS

Abstract Higher energetic cost of walking per unit distance has been linked to many adverse health outcomes in older adults. Aging-related changes in gait characteristics have been postulated to contribute to energetic inefficiency, but previous studies focused on younger adults, and/or examined only a few gait characteristics. In the Baltimore Longitudinal Study of Aging, 507 older adults ≥50 years (72.3±9.8 years, 48.3% women, 48.3% black) without stroke and Parkinson disease had concurrent measurements of usual-paced gait characteristics using 3D motion analysis and energetic cost of walking using indirect calorimetry during a 2.5-min usual-paced overground walk. We tested the associations of the mean and the coefficient of variance (CV) of cadence (steps/min), swing time (ms), double support time (ms), stance time (ms), step time (ms), step length (cm), and step width (cm) with energetic cost of walking using linear regression models, adjusting for demographics, body composition, comorbidities, and gait speed. We found that a 5-cm shorter step length was associated with 0.40 ml/kg/100m higher cost of walking (p&amp;lt; 0.001). A 1% higher CV in swing time and 1% lower CV in step width was associated with 0.152 ml/kg/100m higher (p=0.044) and 0.023 ml/kg/100m lower (p=0.022) cost of walking, respectively. Our results suggest that mean step length and variability in swing time and step width could potentially contribute to the rising cost of walking in older adults. Future longitudinal studies are needed to understand whether changes in gait variability can predict increased energetic cost of walking and can be intervened to preserve energy efficiency.

ASSOCIATIONS BETWEEN POSTURAL SWAY AND GAIT DOMAINS DURING WALKING WHILE TALKING

Abstract Poor gait performance during walking-while-talking (WWT) is associated with an increased falls risk. Whether this association between WWT and falls is moderated by balance is not known. To address this, we examined 1) cross-sectional associations between postural sway and gait domains during WWT and, 2) whether postural sway moderated the effects of gait domains on falls. Gait (using a computerized walkway) and postural sway in anteroposterior (AP) and mediolateral (ML) directions (using the SwayStar™ system) during WWT were assessed in 357 community-dwelling older adults (M Age 77.9 years; 55.5% female). Principal component analysis was used to derive distinct gait domains: pace (speed, step length), rhythm (swing, stance, step time) and variability (step length variability, double support time variability). Falls incidence over 12 months were ascertained using bi-monthly calls. Multiple linear regression (adjusted for age, sex, and education) was used to examine the associations between postural sway and gait domains. Poisson regression was used to examine the associations of number of falls with gait domains and postural sway. Greater AP- and ML-sway were associated with slower pace, greater rhythm, and greater variability (p&amp;lt; 0.005). Slower pace (not rhythm or variability) was associated with falls incidence (n=95) and the effect of pace on falls (although p&amp;gt;0.005) was reduced by the ML-sway (β for interaction between pace and sway -0.001 95%CI -0.002, 0.0001). These findings suggest that greater sway during WWT is associated with poorer gait performance. Interventions to maintain ML-sway during WWT may assist with reducing the effects of pace on falls risk.

Using Wearable Inertial Sensors to Assess Mobility of Patients With Hematologic Cancer and Associations With Chemotherapy-Related Symptoms Before Autologous Hematopoietic Stem Cell Transplant: Cross-sectional Study.

Wearable sensors could be a simple way to quantify and characterize mobility in patients with hematologic cancer scheduled to receive autologous hematopoietic stem cell transplant (autoHSCT) and how they may be related to common treatment-related symptoms and side effects of induction chemotherapy. We aimed to conduct a cross-sectional study comparing mobility in patients scheduled to receive autoHSCT with that in healthy, age-matched adult controls and determine the relationships between patient mobility and chemotherapy-related symptoms. Patients scheduled to receive autoHSCT (78/156, 50%) and controls (78/156, 50%) completed the prescribed performance tests using wearable inertial sensors to quantify mobility including turning (turn duration and number of steps), gait (gait speed, stride time, stride time variability, double support time, coronal trunk range of motion, heel strike angle, and distance traveled), and balance (coronal sway, coronal range, coronal velocity, coronal centroidal frequency, sagittal sway, sagittal range, sagittal velocity, and sagittal centroidal frequency). Patients completed the validated patient-reported questionnaires to assess symptoms common to chemotherapy: chemotherapy-induced peripheral neuropathy (Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity subscale), nausea and pain (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire), fatigue (Patient-Reported Outcomes Measurement Information System Fatigue Short Form 8a), vertigo (Vertigo Symptom Scale-short form), and depression (Center for Epidemiological Studies-Depression). Paired, 2-sided t tests were used to compare mobility between patients and controls. Stepwise multivariable linear regression models were used to evaluate associations between patient mobility and symptoms. Patients aged 60.3 (SD 10.3) years had significantly worse turning (turn duration; P<.001), gait (gait speed, stride time, stride time variability, double support time, heel strike angle, stride length, and distance traveled; all P<.001), and balance (coronal sway; P<.001, range; P<.001, velocity; P=.02, and frequency; P=.02; and sagittal range; P=.008) than controls. In patients, high nausea was associated with worse stride time variability (ß=.001; P=.005) and heel strike angle (ß=-.088; P=.02). Pain was associated with worse gait speed (ß=-.003; P=.003), stride time variability (ß=.012; P=.02), stride length (ß=-.002; P=.004), and distance traveled (ß=-.786; P=.005). Nausea and pain explained 17% to 33% and 14% to 36% of gait variance measured in patients, respectively. Patients scheduled to receive autoHSCT demonstrated worse mobility in multiple turning, gait, and balance domains compared with controls, potentially related in part to nausea and pain. Wearable inertial sensors used in the clinic setting could provide granular information about mobility before further treatment, which may in turn benefit from rehabilitation or symptom management. Future longitudinal studies are needed to better understand temporal changes in mobility and symptoms across the treatment trajectory to optimally time, design, and implement strategies, to preserve functioning in patients with hematologic cancer in the long term.

Gait Correlates of Cognitive Function and Future Decline

AbstractBackgroundSlow walking speed is associated with numerous negative health outcomes including global cognitive decline.1 More detailed gait analysis can differentiate among different dementia subtypes,10 but the predictive power of baseline gait metrics for domain‐specific cognitive decline needs further characterization.MethodWe conducted a follow up study on 534 participants of the Mayo Clinic Study of Aging who underwent evaluations every 15 months (median follow‐up = 5.4 years). We analyzed quantitative gait metrics, acquired with a pressure‐sensing walkway (GAITRite® instrument), and cognitive scores using a linear mixed effects model to identify correlations between z‐scored baseline gait metrics (cadence, swing time, stance time, velocity, double support time (DST), stride length, stride length standard deviation (SD), stride time SD, swing time SD, stance time SD, DST SD) and cognitive domain z‐scores (memory, attention, language, visuospatial, global) at baseline and over time. Models controlled for age, sex, and probable REM sleep behavior disorder at baseline.ResultThe table includes both baseline associations and difference in slopes (Δ), relative to the average person, in cognitive domains. These slopes ranged from about ‐0.05 for visuospatial to ‐0.12 for attention.ConclusionIncreased gait velocity and stride length are associated with less severe domain‐specific and global cognitive decline while increased swing time SD and DST are associated with more severe rates of decline in some domains. These findings suggest that baseline gait characteristics could be a helpful predictor of future cognitive changes.