Profiled double-skin composite walls (PDSCWs) consist of two profiled steel plates and infilled concrete, and they have been widely utilized with the development of prefabricated structure systems. By using re-entrant profiled sheets in PDSCWs, the stability performance of faceplates is greatly enhanced and almost no additional members are needed to connect the faceplates and infilled concrete. Hence, these PDSCWs with re-entrant profiled faceplates have an excellent potential for applications as bearing walls in low- and medium-rise building structures. In view of the simultaneous multi-story fabrication and erection of the PDSCWs in practice, global buckling performance of slender PDSCWs under axial compression is investigated in this paper. A refined finite element (FE) model is established and then validated by previous experimental results. A numerical parametric analysis is conducted to study the PDSCW performance by considering the parameters including geometrical dimensions, steel and concrete strengths, faceplate types and amplitudes of initial imperfection. By comparing the extensive examples obtained from FE models with stability curves in different design codes, the curves in GB50017 and AS2327 are found to be able to conservatively predict the resistance of slender PDSCWs. For better statistical performance, a modified design formula based on curve c in GB50017 is recommended. The proposed formula can fit well with the numerical examples with a more reasonable level of accuracy; therefore, this formula is reliable and can provide valuable references for designing the PDSCWs in practice.