This article analyzes the forced and free vibrations of bi-directional functionally graded (BDFG) porous nanobeams under moving loads by considering the thickness effect based on the nonlocal strain gradient theory (NSGT). It is assumed that the material properties of the system are graded across the transverse and axial directions according to power and exponential laws, respectively. Various porosity models, including even, uneven, and asymmetric porosity distribution patterns, are considered to model the porosity effects. The dynamic equation of the system is derived by implementing the physical neutral surface concept. Analytical and numerical approaches are adopted to acquire the vibration response of the system. Mathematical closed-form expressions are provided for various dynamic phenomena, such as two types of cancelation, two types of resonance, maximum resonance, cancelation disappearance, and resonance disappearance. In addition, for the first time in this article, it is demonstrated that BDFG porous nanobeams under moving loads are prone to experience the double cancelation phenomenon. Several comparison studies with published data are conducted to validate the results. Also, comprehensive parametric studies are carried out to elucidate the impacts of system parameters such as thickness power index, axial gradient parameter, scale parameter ratio, axial force, porosity coefficient, and porosity distribution pattern on the dynamic magnification factor, critical load speed, and maximum free-response. The outcomes established that by considering the thickness effect, the stiffening behavior of the system is amplified depending on the slenderness ratio. Also, it is concluded that, among the considered porous models, the critical load speed for the system with an even porosity distribution is more dependent on the thickness power index.