Double-edged Sword Research Articles

Understanding User Experience with Smart Home Products

ABSTRACT There has been a surge in the popularity of smart home products. Existing literature primarily focuses on the initial adoption of these products, with less attention given to the post-adoption stage. This has created a research gap in understanding user experience (UX) and the key dimensions of user satisfaction and dissatisfaction. This study aims to address this gap by examining both positive and negative user experiences with smart home products. Using robotic vacuum cleaners as a case study, we analyze key UX dimensions derived from their positive and negative reviews on Amazon.com that influence user satisfaction and dissatisfaction, respectively. Dimensions contributing to satisfaction include “functionality,” “smartness,” and “enhanced capacity (mopping feature).” In contrast, “insufficient smartness,” “poor customer service,” and “connectivity problems” are critical dimensions for user dissatisfaction. Notably, “smartness” serves as a double-edged sword, potentially leading to high satisfaction but also significant dissatisfaction if poorly implemented. Our analysis also includes a comparative examination of robotic vacuums with traditional vacuums, highlighting the different UX dimensions associated with each product type. Using fuzzy-set qualitative comparative analysis (fsQCA), we further examine the configurations of these UX dimensions that contribute to satisfaction and dissatisfaction. To generalize our findings, we applied our framework to smart thermostats and proposed a UX model for smart home products. Our findings not only fill the research gap in smart home literature but also offer valuable insights for practitioners in designing smart home products and developing marketing strategies. Our research method can be applied to understand user experience with various types of smart home products and other innovative technologies.

Sharpening the double-edged sword: Revisiting the evolving role of social media within medical education

Sharpening the double-edged sword: Revisiting the evolving role of social media within medical education

The Effect of Job Skill Demands Under Artificial Intelligence Embeddedness on Employees' Job Performance: A Moderated Double-Edged Sword Model.

With the widespread application of AI technology, the skills and abilities required by employees in their work are undergoing fundamental changes, redefining the roles of employees. This research aims to explore the effect of job skill demands under AI embeddedness on well-being in organizations and job performance. Based on conservation of resources theory, this research randomly selected 479 employees from 8 companies in China using a time-lag method as samples, and conducted statistical analysis with ordinary least squares (OLS). This research found that, job skill demands under AI embeddedness will both increase employees' competency needs, promoting their well-being in organizations and job performance and decrease employees' job embeddedness, inhibiting their well-being in organizations and job performance. Meanwhile, technological anxiety moderated the impact of job skill demands under AI embeddedness on job embeddedness.

The Double-Edged Sword: How State Capacity Prolongs Autocratic Tenure but Hastens Democratization

This paper is concerned with state capacity and autocrat survival. We argue that state strength in autocracies increases leader tenure but reduces the stability of the regime itself; stronger autocracies run a higher risk of transitioning to democracy. This trade-off arises as a result of how state capacity affects the behavior of elite challengers. A stronger state reduces the likelihood of the ruler being ousted by force, inducing rival elites to switch tactics to peaceful support for democracy. An autocrat may prolong his tenure by investing in state capacity, but this brings on the downfall of the autocratic regime itself. We analyze the implications of our argument using a variety of historical sources providing information on 47 autocracies from 1800 to 2012. Our empirical findings, in part based on original data collection, are in line with the theoretical expectations: in strong states autocrats survive, but autocracies die.

Microglia-mediated neuroinflammation in traumatic brain injury: a review.

Traumatic brain injury (TBI) is a leading cause of disability worldwide, characterized by a complex interplay of primary and secondary injury mechanisms. Microglia, the resident immune cells of the central nervous system, play a crucial role in the inflammatory response following TBI. To review the current understanding of microglia-mediated neuroinflammation in TBI, exploring its dual nature as a protective and detrimental process. A comprehensive literature review was conducted using databases such as PubMed, Scopus, and Google Scholar. Relevant studies investigating the role of microglia in TBI were included. In the early stages of TBI, microglia exhibit a protective response, releasing cytokines and chemokines to promote neuronal survival and tissue repair. However, prolonged or excessive microglial activation can lead to neurotoxicity and exacerbate secondary injury. Microglia-mediated neuroinflammation involves complex signaling pathways, including Toll-like receptors, purinergic receptors, and the complement system. Microglia-mediated neuroinflammation in TBI is a double-edged sword. While acute microglial activation can promote repair, chronic or excessive inflammation contributes to neuronal damage and functional deficits. Understanding the temporal and molecular dynamics of microglial responses is crucial for developing therapeutic strategies to modulate neuroinflammation and improve outcomes after TBI.

Succeed to culture a novel lineage symbiotic bacterium of Mollicutes which widely found in arthropods intestine uncovers the potential double-edged sword ecological function

Succeed to culture a novel lineage symbiotic bacterium of Mollicutes which widely found in arthropods intestine uncovers the potential double-edged sword ecological function

To Leave or to Stay? Research on the Double-Edged Sword Effect of Illegitimate Tasks on Employee Turnover Intention.

Purpose: This study explores the double-edged sword impact of illegitimate tasks on turnover intention and how this influence is manifested. Design/methodology/approach: Multisource data were collected from employees in different industries in South China at two points in time. The hypotheses were tested with hierarchical multiple regression analysis in combination with PROCESS macro-based bootstrapping. Findings: Illegitimate tasks can both weaken employees' turnover intention by triggering challenge stressor appraisal and enhance employees' turnover intention by triggering hindrance stressor appraisal. The research results confirm the double-edged sword effect of illegitimate tasks on employees' turnover intention. Practical implications: To mitigate employees' turnover intention and reduce turnover rates, organizational managers need to pay attention to the negative impact of illegitimate tasks and be concerned about employees' subjective cognition of these tasks. Additionally, organizations must optimize work design to reduce unnecessary tasks and assign unreasonable tasks to suitable employees. Originality/value: Based on the cognitive appraisal theory of stress, this study constructs a double-edged sword effect model. The results show that illegitimate tasks not only have negative impacts on employee turnover intention but also have potential positive impacts through two mediating pathways: challenge stressor appraisal and hindrance stressor appraisal. The research results indicate that illegitimate tasks have both a dark side and a bright side.

Nursing home leader response during COVID-19: a qualitative descriptive study about use of external resources during the pandemic

BackgroundUS nursing homes were ground zero for COVID-19 and nursing home leaders faced multiple challenges to keep residents and staff safe. Understanding the leader’s role and their use of external resources to rapidly respond to the pandemic is important to better prepare for the next infectious disease outbreak emergency. The purpose of this study is to describe Missouri nursing home leaders’ use of external resources to manage challenges encountered during the pandemic.MethodsThis qualitative descriptive study uses data from semi-structured interviews conducted with leaders from 24 Midwestern nursing homes between March 2022 and March 2023. Interviews were transcribed verbatim and analyzed using Dedoose software. Directed content analysis, guided by Donabedian’s Structure, Process, Outcome framework, was used for analysis. Interviews were conducted as part of a larger mixed-methods study focused on developing knowledge and recommendations to improve US nursing homes’ capacity to respond to infectious disease outbreaks.ResultsForty-three interviews were conducted across the 24 homes. Participants included administrators (n = 24), nurse leaders (n = 19), and infection preventionists (n = 16). Six sub-categories of external resources/support were used by leaders to manage challenges during the pandemic:1) corporate support and communications, 2) statewide resources, 3) community-based resources, 4) health care coalitions focused on emergency response planning, 5) existing affiliations with local organizations i.e., hospitals, and 6) community members and families. Corporate support was a primary resource; however, it was limited to chain-based homes. Leaders from standalone homes seemed most reliant on statewide agencies, existing affiliations, and other community-based resources due to their lack of corporate connections. Health care coalitions were few, but when available, helped nursing homes prepare for the pandemic onset. Family and community members were vital despite being off-site from nursing homes at the pandemic onset.ConclusionLeaders played a pivotal role in accessing and using external resources to manage challenges during the pandemic. Statewide and community-based agencies and existing affiliations were particularly critical for standalone homes who otherwise had little to no means of support. Federal, state and local agencies must consider opportunities to build multi-agency regional collaborations, local health care coalitions and community-based partnerships that include nursing homes as member. Finally, community members and family were important in providing support, thus closing visitation is a double-edged sword that needs careful, future consideration.

Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer.

Environmental exposure to a mixture of chemical xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis and the development of breast cancer (BC). Before anything else, we are what we eat. In this review, we highlight both "the good" and "the bad" sides of the daily human diet and dietary patterns that could influence BC risk (BCR) and incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, and raw food, increases apoptosis and autophagy, antioxidation, cell cycle arrest, anti-inflammation, and the immune response against BC cells. Moreover, a healthy diet could lead to a reduction in or the inhibition of genomic instability, BC cell stemness, growth, proliferation, invasion, migration, and distant metastasis. We also emphasize that, in addition to beneficial compounds, our food is more and more contaminated by chemicals with harmful effects, which interact with each other and with endogenous proteins and lipids, resulting in synergistic or antagonistic effects. Thus, a healthy and diverse diet, combined with appropriate nutritional behaviors, can exert anti-carcinogenic effects and improve treatment efficacy, BC patient outcomes, and the overall quality of life of BC patients.

The double-edged sword of transparency: ESG disclosure's effect on competitive dynamics in manufacturing

This study explores the role and impact of Environmental, Social, and Governance (ESG) information on investor decision-making, focusing on the lack of standardized ESG reporting among companies. Although ESG disclosures can enhance a company’s legitimacy and attract investor interest, the voluntary nature of reporting has led to inconsistent practices and limited information quality. The research aims to develop a standardized ESG reporting model that meets investor needs while assessing the effects of ESG performance on corporate outcomes. Using a mixed-methods approach, the study combines qualitative research to formulate an ESG reporting model and quantitative methods to evaluate its impact on company performance. Data were collected from 167 manufacturing companies in Indonesia, selected based on their consistent publication of sustainability reports over four consecutive years. The findings reveal that ESG shows consistent high significance across all three models (Sig = 0.000 for Model-1, Model-2, and Model-3 regression). This uniform high significance underscores the growing importance of ESG factors in various aspects of corporate performance and perception. It suggests that ESG considerations are integral not only to stock returns and firm valuation but also to a company's competitive positioning. The study concludes that while ESG reporting is essential for corporate transparency, it may not always align with positive financial outcomes. This suggests the need for more comprehensive ESG frameworks to balance investor expectations and corporate performance.

Transparency and fact-checking in open societies

Transparency is more than a motto for professional fact-checkers; it is a professional requirement that permeates their daily practice. Although transparency has been theorised and critiqued extensively in journalism studies, there has been less research on its practical implications for news workers. This paper aims to fill this gap by focusing on fact-checking practices in the Nordic countries. The paper highlights the double-edged sword of transparency by drawing on 14 semistructured interviews with fact-checkers and newsroom managers from the four independent fact-checking organisations in Finland, Sweden, Norway and Denmark. Transparency is seen as a means to achieve accountability and credibility in reporting and as a tool to hold public figures accountable. However, transparency does not protect Nordic fact-checkers from criticism or harassment for delivering uncomfortable truths. This study also links fact-checkers discourses with the material traces of transparency on their respective websites, showing that transparency can be approached differently in practice. This research provides valuable insights into the nuanced role of transparency in fact-checkers’ daily routines while acknowledging its limitations in that transparency is not without flaws, even in societies characterised by a culture of openness and transparency.

The Double-Edged Sword Property of Mesenchymal Stem Cell-Derived Exosomal microRNAs in Colorectal Cancer.

Mesenchymal stem cells (MSCs)-based therapies are promising therapeutic strategies for cancer treatment, because of their strong immunomodulatory and tissue regeneration abilities. In case of colorectal cancer (CRC), MSCs indicate a double-edged sword activity. Some reports declared the inhibitory effects of MSCs on the proliferation, migration, and infiltration of cancer cells to suppress the CRC initiation and development, whereas others showed the tumor-promoter impacts of MSCs on the progression of CRC. Recent investigations have revealed that exosomal microRNAs (Exo-miRs) derived from MSCs (MSCs-Exo-miRs) are attributed to such paradoxical effect. Thus, the current review aimed to seek the role of MSCs-Exo-miRs in CRC progression and their therapeutic potential for the CRC treatment.

Hormones as a double-edged sword: the role of hormones in cancer progression and the potential of targeted hormone therapies.

Cancer remains a significant cause of mortality in the world, with increasing prevalence worldwide. There are numerous treatments ranging from surgery to chemotherapy and radiotherapy, but since cancer is a heterogeneous disease, only few patients possibly respond to treatments. However, it opens a huge space for the advent of targeted therapies such as hormone therapy, immunotherapy, and target-specific drugs. Hormonal therapy using hormone agonists/antagonists or hormone receptor inhibitors-called the next-generation hormonal agents-hits distinct hormonal pathways that are involved in breast, prostate and ovarian cancer. Preliminary results show that through combination of drugs, it is possible that the synergistic effects may actually lead to better survival than with the use of single drugs. With manageable adverse effects, hormonal therapy offers much hope for treatment of this rather challenging malignancy of the hormone-sensitive cancers, especially in combination with other treatments.

Career Booster or Dead End? The Double-Edged Sword Effects of Entrepreneurial Fear of Failure on Entrepreneurial Exit Intentions in the Process of Sustainable Entrepreneurship

Based on self-regulation theory, this paper constructs two paths through which entrepreneurial fear of failure affects entrepreneurial exit intentions, and explores the moderating effect of the locus of control. We analyze a sample of 308 entrepreneurs from small and medium-sized private enterprises located in Southeast China. The results shown that entrepreneurial fear of failure not only stimulates entrepreneurial identity centrality in a self-regulated driving state but also leads to emotional exhaustion in a state of self-regulated depletion, with two effects on entrepreneurial exit intentions. The facilitating effect of entrepreneurial fear of failure on entrepreneurial identity centrality is stronger for internals than externals, whereas the facilitating effect of entrepreneurial fear of failure on emotional exhaustion is stronger for externals than internals. This research provides a theoretical basis and managerial insights for using entrepreneurial fear of failure to motivate its promoting effects and inhibit its hindering effects on sustainable entrepreneurship.

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy.

Adaptive anti-tumor immunity is currently dependent on the natural immune system of the body. The emergence of tumor immunotherapy has improved prognosis and prolonged the survival cycle of patients. Current mainstream immunotherapies, including immune checkpoint blockade, chimeric antigen receptor T-cell immunotherapy, and monoclonal antibody therapy, are linked to natural immunity. The cGAS-STING pathway is an important natural immunity signaling pathway that plays an important role in fighting against the invasion of foreign pathogens and maintaining the homeostasis of the organism. Increasing evidence suggests that the cGAS-STING pathway plays a key role in tumor immunity, and the combination of STING-related agonists can significantly enhance the efficacy of immunotherapy and reduce the emergence of immunotherapeutic resistance. However, the cGAS-STING pathway is a double-edged sword, and its activation can enhance anti-tumor immunity and immunosuppression. Immunosuppressive cells, including M2 macrophages, MDSC, and regulatory T cells, in the tumor microenvironment play a crucial role in tumor escape, thereby affecting the immunotherapy effect. The cGAS-STING signaling pathway can bi-directionally regulate this group of immunosuppressive cells, and targeting this pathway can affect the function of immunosuppressive cells, providing new ideas for immunotherapy. In this study, we summarize the activation pathway of the cGAS-STING pathway and its immunological function and elaborate on the key role of this pathway in immune escape mediated by the tumor immunosuppressive microenvironment. Finally, we summarize the mainstream immunotherapeutic approaches related to this pathway and explore ways to improve them, thereby providing guidelines for further clinical services.

Is there a danger of making customers feel too empowered? Exploring the double-edged sword of customer orientation and creative benefits

Purpose This study aims to explore the extent to which customer orientation and creative benefits offered by a firm may weaken rather than strengthen customer engagement. In doing so, it sheds new light on how customer orientation and creative benefits may facilitate rather than hinder engagement by customers. Design/methodology/approach A field study provides a test of the proposed effects in a hedonic consumption setting with 1,703 customers of an online dating service. Furthermore, an experimental study with 277 executives in a functional consumption setting (new mobile app) helps affirm the robustness of the field study findings. Findings This research theorizes and examines how communal relationship norms between customers and a firm, along with customers’ psychological empowerment, mediate the effect of customer orientation and creative benefits on customer engagement. A provocative finding of the study is that communal relationship norms help boost, whereas psychological empowerment reduces, the effects of both customer orientation and creative benefits on customer engagement. Research limitations/implications The research examines different relationship norms and how they can become integral to customer–company relationships; this perspective helps reveal the underlying dynamics. It contributes to the literature on customer engagement by theorizing and demonstrating the link between customer orientation and customer engagement, two central constructs in the marketing literature. It theorizes and demonstrates that providing creative benefits brings about a direct competitive advantage for the product itself, and acts as a significant variable that explains the company−customer relationship. Practical implications The findings highlight the advantages and challenges associated with encouraging customer engagement. First, they suggest that companies emphasize their customer orientation and creative benefits. Second, managers should try to minimize the possible process of raising customers’ psychological empowerment while maximizing the impact of communal relationship norms. Originality/value This study identifies psychological empowerment as a key reason customer-oriented companies that provide creative benefits still struggle to engage their customers. It also suggests viable tactics to overcome barriers to enhanced customer engagement, such as by minimizing the effects of customers’ psychological empowerment while maximizing the impact of their perceived communal relationship norms.

Upregulated DNMT3a coupling with inhibiting p62-dependent autophagy contributes to NNK tumorigenicity in human bronchial epithelial cells

NNK, formally known as 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanoe, is a potent chemical carcinogen prevalent in cigarette smoke and is a key contributor to the development of human lung adenocarcinomas. On the other hand, autophagy plays a complex role in cancer development, acting as a "double-edged sword" whose impact varies depending on the cancer type and stage. Despite this, the relationship between autophagy and NNK-induced lung carcinogenesis remains largely unexplored. Our current study uncovers a marked reduction in p62 protein expression in both lung adenocarcinomas and lung tissues of mice exposed to cigarette smoke. Interestingly, this reduction appears to be contingent upon the activity of extrahepatic cytochrome P450 (CYP450), revealing that NNK metabolic activation by CYP450 enzyme escalates its potential to induce p62 downregulation. Further mechanistic investigations reveal that NNK suppresses autophagy by accelerating the degradation of p62 mRNA, thereby promoting the malignant transformation of human bronchial epithelial cells. This degradation process is facilitated by the hypermethylation of the Human antigen R (HuR) promoter, resulting in the transcriptional repression of HuR - a key regulator responsible for stabilizing p62 mRNA through direct binding. This hypermethylation is triggered by the activation of ribosomal protein S6, which is influenced by NNK exposure and subsequently amplifies the translation of DNA methyltransferase 3 alpha (DNMT3a). These findings provide crucial insights into the nature of p62 in both the development and potential treatment of tobacco-related lung cancer.

The Privilege of Territory: Christian Wolff at the Origins of Statist International Thought

The modern state is often taken as the only legitimate claimant to the division of the globe. Political theorists offer many theories of territorial rights but tend to agree that the state remains the proper institutional bearer of such rights. This article examines how states became the exclusive bearers of territorial rights by returning to the international theory of the eighteenth-century Prussian jurist Christian Wolff (1679–1754), who wrote in a moment when sovereign states were not the heirs apparent to the globe but competed with other claimants to territorial rights. Despite proposing a radically pluralistic and anti-imperial account of land ownership, Wolff nonetheless paved the way for the state to become the sole bearer of territorial rights. Wolff’s international thought is an illustration of how building a state-centric international order was a double-edged sword: it criticized imperial overreach while also closing the international arena to nonstate forms of collective life. In this process, he offered two distinct ideas of political space: the territorial space of states, and the land ownership tracts of nonstate peoples, including pastoralists and nomads. To Wolff, only states were entitled to full and permanent territorial rights, while nonstate peoples were shut out of the international system, made both de facto and de jure stateless.

Loss of Carbamoyl Phosphate Synthetase 1 Potentiates Hepatocellular Carcinoma Metastasis by Reducing Aspartate Level.

Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Numerous studies have shown that metabolic reprogramming is crucial for the development of HCC. Carbamoyl phosphate synthase 1 (CPS1), a rate-limiting enzyme in urea cycle, is an abundant protein in normal hepatocytes, however, lacking systemic research in HCC. It is found that CPS1 is low-expressed in HCC tissues and circulating tumor cells, negatively correlated with HCC stage and prognosis. Further study reveals that CPS1 is a double-edged sword. On the one hand, it inhibits the activity of phosphatidylcholine-specific phospholipase C to block the biosynthesis of diacylglycerol (DAG), leading to the downregulation of the DAG/protein kinase C pathway to inhibit invasion and metastasis of cancer cells. On the other hand, CPS1 promotes cell proliferation by increasing intracellular S-adenosylmethionin to enhance the m6A modification of solute carrier family 1 member 3 mRNA, a key transporter for aspartate intake. Finally, CPS1 overexpressing adeno-associated virus can dampen HCC progression. Collectively, this results uncovered that CPS1 is a switch between HCC proliferation and metastasis by increasing intracellular aspartate level.

When knowledge workers meet AI? The double-edged sword effects of AI adoption on innovative work behavior

Purpose The purpose of this study was to investigate the impact of artificial intelligence (AI) adoption on knowledge workers' innovative work behaviors (IWB), as well as the mediating role of stress appraisal and the moderating role of individual learning abilities. Design/methodology/approach This study analyzed the questionnaire results of 313 knowledge workers, and data analysis was conducted by using SPSS 25.0, SPSS 25.0 macro-PROCESS and AMOS 28.0. Findings This study found that AI adoption has a double-edged sword effect on knowledge workers' IWB. Specifically, AI adoption can promote IWB by enhancing knowledge workers' challenging stress appraisal, while inhibiting IWB by fostering their hindering stress appraisal. Moreover, individual learning ability significantly moderated the relationship between AI adoption and stress appraisal, which further influenced IWB. Originality/value This study integrates the conflicting findings of previous studies and proposes a comprehensive theoretical model based on the theory of cognitive appraisal of stress. This study enriches the research on AI in the field of knowledge management, especially extending the understanding of the relationship between AI adoption and knowledge workers’ IWB by unraveling the psychological mechanisms and behavior outcomes of users' technology usage. Additionally, we provide new insights and suggestions for organizations to seek the cooperation and support of employees in introducing new technologies or driving intelligent transformation.