DOTS Therapy Research Articles

Adjunct therapy of Jivantyadi Ghrita with Anti Tubercular drugs in Rajyakshama (Pulmonary Tuberculosis) – A Case Report

Rajyakshma is oldest disease known to mankind as its first reference found in oldest literature Rugveda. It is called as King of Diseases, which indicates its severity. Tuberculosis remains major public health problem not only in India but also in world. According to WHO one third of global population is suffering from tuberculosis. Anti-tubercular therapy is long lasting and has many side effects, so it is necessary to develop adjunct therapy which will minimize the hazards and help patient to improve the immune status. Aims and objective – To evaluate the toxicity reduction and early restoration by adjunct therapy of Jivantyadi Ghrit. Methodology - In the present case study DOTs therapy in the dose of 3 tablets once per day was given as an adjunct with Jivantyadi Ghrit 10 ml BD per day was administered for a period of 6 months in the diagnosed case of pulmonary tuberculosis. Assessment was recorded. Results – WBC count and ESR rate reduced to normal, Haemoglobin level increased, SGPT and Sr. Bilurubin level remains normal. Also significant resolution of lung Koch’s lesions was noted radiologically. Conclusion - Jivantyadi Ghrit as an adjunct therapy with DOTs reduces the side effects (especially hepatic) of DOTs therapy and also shows significant clinical improvement in sign and symptoms of PTB.

Factors Contributing to TB at Primary Health Center in Sidoarjo - Indonesia

Introduction: Tuberculosis (TB) is caused by Mycobacterium tuberculosis, and remains a burden in Indonesia. Many factors contribute to the TB prevalence, including age, sex, body mass index, sputum smear conversion, HIV infection, and Diabetes Mellitus. The objective of this study is to identify factors contributing to TB prevalency at the primary health center.Methods: This research used as a cross-sectional study and was conducted in March 2020. The population of this study was TB patients at Porong Primary Health Center in Sidoarjo, East Java Province, Indonesia. Samples were all TB patients who registered in Porong Primary Health Center and were taken by total sampling. The sample size was 51 TB patients. There were no inclusion and exclusion samples criteria implemented. Data were collected that used the secondary data of TB Patients Registration, between 1st – 31st March April 2020. Data were analyzed using frequency distribution with SPSS Version 21.Results: Result shows there were 30 (58.80%) male TB patients, 34(66.70%) TB patients were adults, 48 (94.10%) TB patients had sputum smear conversion from positive to negative after two months DOTS therapy, there were 48 (94,10%) TB patients not infected by HIV Virus, and there were 36 (70,60%) TB patients had a history of Diabetes Mellitus.Conclusion: Factors contributing to TB prevalence are many, including age, sex, body mass index, sputum smear conversion, HIV infected, and Diabetes Mellitus. To improve care of TB patients requires integration and comprehension of care at the primary health center.

Predominance of Streptococcus pneumoniae among TB patients complicates Dots chemotherapy at infectious diseases hospital Kano, Northwest Nigeria

Directly observed treatment Short course regimen has been know to be efficacious in the chemotherapy management of tuberculosis. However, co- infection with other opportunistic bacteria could limit this success to the level of clinical suspecting the emergence of false positive multidrugs resistant TB among the patients which in many cases can lead to establishment of erroneous treatment schedule. Accordingly this facility based surveillance monitors co-infection with other bacteria in TB patients attending Dots clinic at IDH Kano, Nigeria with view to ascertaining the drug susceptibility so as to proffer better chemotherapy strategies. A total 35 non - duplicated positive AFB sputum sample collected from patients with pulmonary tuberculosis on Dots where processed according to standard bacteriological procedures including macroscopic, culture and microscopic examination using both AFB gram staining and culture methods for screening and isolation of other bacterial pathogens. These were confirmed biochemically. Overall 54.3% of the patients were Still AFB positive, Streptococcus pneumoniae and Staphylococcus species we’re predominat in up to 84.2% and 15.8% of the patients respectively. This study indicated secondary bacterial pathogenesis with pulmonary symptoms resembling TB among the patients including those that were even isolated for being refrectory to Dots an false positive conclusion of drug resistant TB. However, ofloxacin and ceftriaxone which show appreciable potencies against secondary bacterial pathogens identified where used to treat successfully, patients claimed posses drug resistant TB. It’s imperative that, success of Dots therapy could be improved by augumentin with very potent non TB antibacterial such as Streptococcus pneumoniae regimen. Keys. TB.

An Exploratory Study To Identify Factors Affecting Non Compliance To Dots Therapy Among Tb Patients At Selected Dots Centre Vadodara

An Exploratory Study To Identify Factors Affecting Non Compliance To Dots Therapy Among Tb Patients At Selected Dots Centre Vadodara

Mobile health to improve adherence to tuberculosis treatment in Khartoum state, Sudan.

Although tuberculosis is a treatable disease, the high frequency of treatment default remains a challenge. The use of mobile phones structurally in a TB program has the potential to lower the frequency of default. However, it’s impact on treatment outcome in Sudan has not yet been evaluated. The aim is to evaluate the potential use of cell phones for lowering treatment default. We conducted a controlled intervention pilot study during the period from 1st of May 2017 to 31st of March 2018, in eight TB treatment units in Khartoum state, Sudan. Newly diagnosed patient with positive sputum smear on DOTS therapy were enrolled in intervention and control groups. SMS reminder were sent to the intervention group.Assessments were done at the beginning and at the end of the treatment. One hundred and forty-eight patients were enrolled, seventy-four patients in each group.The participants in the two groups were similar in demographic characteristics and behavioral and knowledge related factors about TB disease at baseline. The patients in the intervention group had a lower default rate (6.8%), higher documented cure rate (78.4%), better knowledge compared to control group. SMS reminder was useful and facilitated good interaction between patients and health personnel. Mobile texting seemed useful and was highly accepted by participants. Further evaluation of it’s potential benefit was warranted.

Adverse drug reaction prevalence and mechanisms of action of first-line anti-tubercular drugs

PurposeUnderstanding the appearance of anti-tubercular drug-related adverse drug reactions (ADRs) in patients receiving tuberculosis (TB) treatment is important, and may be related to morbidity and mortality if not recognized early. Here, we aimed to characterize the mechanisms underlying adverse drug reactions due to combination anti-tuberculosis therapy of the Revised National Tuberculosis Control Program (RNTCP). MethodsThis was a prospective observational study conducted in 9 DOTS centers of New Delhi, India. All enrolled TB patients receiving first-line tuberculosis treatment as per RNTCP guidelines were monitored for ADRs. All ADRs that appeared during the treatment were recorded and analyzed. ResultsThe study included 1011 TB patients on anti-TB treatment under DOTS. According to Naranjo’s probability scale, of a total 351 (34.72%) reported adverse events, 102 (10.09%) were definite, 59 (5.83%) probable, 123 (12.17%) possible, and 67 (6.63%) doubtful. On the Hartwig severity scale, of the 351 adverse drug events, 225 (22.26%) were mild, 105 (10.38%) were moderate, and 21 (2.08%) were severe. Out of 102 reported adverse drug reactions, 81 (79.41%) were moderate and 21 (20.59%), while 65.28% did not experience any ADRs. ConclusionsDirectly Observed Treatment (DOT) is effective and safe compared to daily treatment regimens. Patients receiving DOTS therapy needed close monitoring for adverse events. Therefore, a pharmacovigilance program should be added at the National level to accesses the adverse event incidence.

Factors Associated with Treatment Compliance among Tuberculosis Patients Receiving Directly Observed Treatment Short Course Therapy

Tubercular infection is still a pervasive public health problem in Nepal despite the massive efforts of National Health Service stakeholders. This study was carried out to identify the factors associated with treatment compliance among Tuberculosis Patients Receiving DOTS in 11 centres of Pokhara valley. A cross-sectional descriptive study design was used to collect information from 142 Tuberculosis patients. Purposive sampling method was used and chi-square test was used at 5% level of significance. Pattern of compliance was categorized as; compliance and non-compliance. Out of 142 respondents, majority (94.37%) of respondents was compliant and minority (5.63%) was non-compliant. Among non-compliant patients, (75.0%) of respondents missed their medicine in intensive phase and the reasons for non-compliance were carelessness of patients, forgetfulness of patients, confusion of staff, side effects of medicines and agitation by political parties. The study found no significant association of treatment compliance with demographic factors, patient related factors, health service factors and social factors (p>0.05). The finding was satisfactory that the compliance of TB patients was high i.e. (94.37%) of respondents were compliant. About (6.00%) of respondents were non-compliant. The reasons for non-compliance were due to their own cause rather than health service factors. They themselves were responsible for being non-compliant. Tuberculosis, being a major public health problem; six percent non-compliance is still a serious health problem and being non-compliant; these patients can transmit tuberculosis to many other healthy people in the family and community. Therefore, tuberculosis patients should be more conscious on treatment compliance to improve their health as well as of family and community.
 Key words: Compliance, non-compliance, DOTS Therapy

Comparative Clinical Assessment of Efficacy of Shataputi Abhrak Bhasma Along With Chausasti Pippali as an Adjuvant to AKT in Pulmonary TB

Worldwide, tuberculosis (TB) is one of the top 10 causes of death, and the leading cause from a single infectious agent. It has been reported that millions of people continue to fall sick with TB each year. Since 1994, with endorsement from WHO; DOTS, Directly Observed Treatment Short-course strategy has been implemented worldwide for control of TB. However, the increasing incidence of TB suggests the need for newer medicines, especially from Ayurveda. Rajayakshma has been correlated with pulmonary tuberculosis due to a great deal of similarities in their manifestations. Abhraka Bhasma and Chausasti Pippali are widely used by Ayurvedic physicians for the treatment of various respiratory diseases. This study was designed to elucidate their anti-tubercular efficacy as an adjuvant to DOTS therapy. The study was conducted on 60 patients diagnosed with Pulmonary TB and showing signs and symptoms of Rajayakshma. They were divided into two groups. The study duration was two months. As per the observations, it was seen that, though both groups were receiving anti-tubercular drugs; the response in the group B patients (DOTS with Shataputi Abhraka Bhasma and Chausasti Pippali) was comparatively better and earlier in some of the symptoms studied. The subjective feeling of the sense of well being was enhanced and reported earlier by the patients of Group B. It can be concluded that co-administration of Shataputi Abhrak Bhasma and Chausasti Pippali along with AKT provided better outcome.

Adverse drug reactions impact on DOTS therapy courses in tuberculosis patients at bidar institute of medical sciences

Adverse drug reactions impact on DOTS therapy courses in tuberculosis patients at bidar institute of medical sciences - IJPP- Print ISSN No: - 2393-9079 Online ISSN No:- 2393-9087 Article DOI No:- 10.18231/j.ijpp.2019.010, Indian Journal of Pharmacy and Pharmacology-Indian J Pharm Pharmacol

A prospective observational pharmacovigilance study of adverse drug reaction monitoring in patients of tuberculosis receiving category I and II treatment regimens at tertiary care hospital

Background: First line Anti-TB therapy with rifampicin, isoniazid, pyrazinamide, and ethambutol / streptomycin is very effective. However, major adverse reactions to antituberculous drugs can cause significant morbidity and mortality. One of the main reasons for non‑adherence to anti‑TB therapy (ATT) is ADRs, even under DOTS. Present study was carried out in tertiary care hospital. The objective of the study was to evaluate types and frequency of ADRs in intensive and continuation phase of category I and II Anti-TB medication.Methods: A prospective observational study conducted in Department of TB- Chest and Medicine, Govt. Medical College, Aurangabad, Maharashtra, India. All the TB patients reporting at DOTS Center of institute were enrolled and monitored for ADRs. The causality and severity of the reactions were determined using Naranjo algorithm and Hartwig questionnaire.Results: Total, n = 241 tuberculosis patients on DOTS therapy were enrolled for the study. Out of 241 patients, 17 were dropouts so 224 patients assessed for ADRs. 127 (56.69%) developed adverse drug reactions. The higher numbers of ADRs were observed in age group 31-40 yrs followed by 21-30 yrs, ADRs were more common in men. Pulmonary TB (73.66%) cases were more common than extra pulmonary TB. Majority of adverse drug reactions were Gastrointestinal (GI) problems (30.92%), followed by Liver dysfunction and Hepatotoxicity (20.39%) and skin problems (17.10%). The causality of ADRs, in majority cases were found to be Probable (56.57%). Around 19 patients require treatment interruption and most of the patients were managed with supportive medication without removing anti tubercular drug from regimen.Conclusions: ADRs are major limiting factor for completion of drug therapy under RNTCP and occurrence of drug resistance which requires attention of all health care professionals.

A Study on Treatment Defaulters in Tuberculosis Patients on Dots Therapy

Tuberculosis is an infectious airborne, chronic granulomatous bacterial disease which requires a prolonged treatment to get a complete cure and prevent death, relapse, resistance to drugs and spreading it to the community. Present study was focused on treatment defaulters among tuberculosis patients receiving dots therapy. A prospective observational study was carried out in the in-patient and outpatient department of pulmonary medicine and other departments with dots referral in a hospital setting for a period of eight months from September 2017- April 2018. During the study period all the patients who was administered with dots therapy for the treatment of tuberculosis were enrolled as per the study criteria. All the patients were interviewed to know there treatment status and also monitored there ADR to check compliance with dots therapy. All the datas were analyzed using descriptive statistics. Out of 90 patients, 21 patients interrupted the treatment, of which 12 were defaulters. The overall percentage of the default to the treatment was 13.3%. The case fatality rate was 4.4%. The mean age of defaulting was found to be 53.3 years and the highest percentage were in the age group 50-65years. Male patients, rural domicile, patients pursuing primary education, pulmonary TB patients were high among the defaulters. Distance (58.3%) transportation (25%), staying alone (16.7%), workload (25%) were the general problems felt by the defaulters. 41.7% were dissatisfied with the behavior of dots provider and 50% of them did not have family support. Patients interrupted treatment in there early phases (41.7% in intensive phase and 58% in early continuous phase). The reasons to default were feeling of wellbeing after the treatment (41.7%), side effects (25.0%). Migration, non-availability of medicines, affording transport charges, medical issues were the other reasons (8.3%). Out of 90 patients, 17 (18.9%) patients came out with a total of 24 ADRs. From this only 2 patients had defaulted from the treatment due to intolerance from the medicational Side effects. ADR monitoring improved the knowledge (from 4.9 to 8.2) and treatment (1.2 to 2.5) of the patient in the current study. From the study we came to conclude that Defaulting was seen mainly due to unawareness, carelessness, disbelief of the treatment method. This can be enhanced by patient education, interviewing them periodically, Monitoring the treatment condition and side effects. So the Clinical pharmacists is responsible in promoting the dots therapy to improve the patients adherence towards it, there by achieving a well treatment outcome

A Study to assess the factor affecting compliance of DOTS Therapy among the Tuberculosis patient at selected DOTS centre of Mehsana District

A Study to assess the factor affecting compliance of DOTS Therapy among the Tuberculosis patient at selected DOTS centre of Mehsana District

A prospective observational pharmacovigilance study of adverse drug reaction monitoring in patients of MDR-TB at tertiary care hospital

Background: The emergence of drug resistant mycobacteria has become a significant public health problem world over creating an obstacle to effective TB control. ADRs are common in patients of MDR-TB on DOTs-Plus drug regimen. Present study was carried out in tertiary care hospital. Identification of types and frequency of adverse drug reactions in Intensive and continuation phase of MDR-TB Patients.Methods: It was a prospective observational study conducted in Department of TB- Chest and Medicine, Govt. Medical College, Aurangabad, Maharashtra, India. All the MDR-TB patients admitted at the directly observed treatment, short course plus (DOTS plus) Center at Medical College Hospital were enrolled and were monitored for ADRs. The causality and severity of the reactions were determined using Naranjo algorithm and Hartwig questionnaire, respectively.Results: A total of 121 tuberculosis patients of MDR-TB on DOTS therapy were enrolled for the study. Out of 121 patients, 13 were dropouts, 6 died, 7 defaulted so 108 patients assessed for ADRs, 48 patients developed 61 (56.48%) adverse drug reactions. The higher numbers of ADRs were observed in age group 31-40yrs followed by 21-30yrs which were more common in men. Majority of adverse drug reactions were Gastrointestinal (GI) problems 32 (52.45%), followed by Ototoxicity 7 (11.48%) and Psychiatric Manifestations 6 (9.84%) and skin problems 3 (4.92%). On evaluation of the causality of ADRs, majority were found to be Possible (59.02%). The severity assessment showed that most of the patients ADRs were of moderate level (50.82%).Some patients required treatment withdrawal and replacement with other drug and most of the patients were managed with supportive medication without removing anti-tubercular drug from their treatment regimen.Conclusions: ADRs are major factor limiting completion of drug therapy under RNTCP and occurrence of drug resistance which requires attention of all health care professionals.

Hubungan antara Tingkat Pengetahuan Pasien dan Pengawas Menelan Obat (PMO) dengan Kepatuhan Pasien Tuberkulosis di Puskesmas Kabupaten Jember


 Tuberculosis (TB) is an infectious disease that mostly affects developing countries. In Indonesia, TB incidence increases every year due to patient inadherence to the standard DOTS therapy. The TB patients inadherence can be associated with poor knowledge among patients and treatment observers. This cross-sectional research aimed to explore the correlation between knowledge level of TB patients and their treatment observers and patient adherence. Purposive sampling technique was used to collect data from 65 respondents from their primary health centers in Jember Regency, East Java. Knowledge of the respondents was evaluated using a 16 items questionnaire and patient adherence was assesed using the translated version of morisky medication adherence scale-8 (MMAS-8) questionnaire. The Spearman Rho correlation test resulted in p value of 0,043 between patients knowledge and patients adherence. Statistically significant correlation was also found between the knowledge of treatment observers and TB patients adherence (p= 0,015). These results suggested the needs to improve knowledge about TB not only for TB patients, but also their treatment observers. 
 
 Keywords: TB patient, treatment observer, knowledge, compliance

A Study of Treatment Outcomes in Patients with Tuberculosis and Diabetes Mellitus on DOTS Therapy in Goa

A Study of Treatment Outcomes in Patients with Tuberculosis and Diabetes Mellitus on DOTS Therapy in Goa

Assess the knowledge and associated factors of DOTS defaulter among tuberculosis clients

Backgroud of the study : Tuberculosis is the second most important cause of adult death worldwide due to infectious disease, after HIV/AIDS. Roughly 13.2 million (new and old cases), new cases 9.2 million every year are affected globally. Aims and Objectives: 1.To assess the factors associated with the DOTS defaulter among TB clients at selected area. 2. 2. To associate the knowledge on control and prevention of tuberculosis among TB clients at selected area. Methods and material: The main aim of the study was to assess the factors associated with DOTS defaulter among TB clients at selected area. The study was a descriptive in nature 30 samples were selected by simple random sampling technique. The tool used for this study was structured questionnaire method on DOTS therapy among TB clients. The collected data were tabulated and analyzed by using descriptive and inferential statistics. Results: The result reveals that out of 30 samples 15 members had moderate knowledge, 6 members had inadequate knowledge and 9 members had adequate knowledge and also the findings of the study revealed that there was a significant association between demographic variables. Conclusion: Despite meeting the WHO goals for default and treatment failure, it is important to aggressively address those aspects that can be changed so the country can continue to reduce the burden of TB on its community. Recommendations are made from the results of this study that may help improve adherence to DOTS programmes.

A Study to Assess the Knowledge of Staff Nurses Regarding DOTS Therapy in View of the Preparation of Informational Booklet at Tertiary Care Hospital, Amritsar, Punjab, India

A Study to Assess the Knowledge of Staff Nurses Regarding DOTS Therapy in View of the Preparation of Informational Booklet at Tertiary Care Hospital, Amritsar, Punjab, India

AN EVALUATION OF TREATMENT OUTCOME IN TUBERCULOSIS DIRECTLY OBSERVED TREATMENT SHORT COURSE FACILITIES IN JIGAWA STATE, NIGERIA (2010–2014)

Tuberculosis (TB) is a major public health problem worldwide. It is estimated that 2 billion people, a third of the world population, have TB infection, but are not down with the disease. Globally, incident cases of TB showed a rising trend, with a 6.6 million reported in 1990, 8.3 million in 2000, 9.24 million in 2004, and an estimated 9.27 million incident cases in 2007. The aim of this study was to evaluate the treatment outcome of TB patients in Nigeria in the state of Jigawa. A cross sectional retrospective study was conducted to evaluate the treatment outcome in directly observed treatment with a short course for tuberculosis (TB DOTS) in facilities in the state between the years 2010 to 2014. The study population were all the patients with TB, who had access to DOTS therapy. Data were collected from the various local governmental areas for tuberculosis control (LGA TB) register. The LGA TB control registers contained basic information of the patients, and a statistical software SPSS-V22.0 was used to analyse the data. A total of 963 TB patients were studied. More than half (57.4%) of the patients were male, and nearly three- fourths (71.2%) of the patients accessed care from urban local government areas in the state. The greater majority (96.3%) of the cases had pulmonary tuberculosis (PTB). Among the patients, more than two-fifths (45%) were cured, and a little over one-fifth (20.6%) of them were HIV positive. This study revealed that the treatment success rate (TSR) in the Jigawa State of Nigeria was higher than the overall TSR of Nigeria, and the defaulter rate in this state was lower than the Nigerian average.

Epidemiological surveillance of tuberculosis among HIV/AIDS seropositive individuals attending ART center at a tertiary care teaching hospital

Background:HIBackground: HIV/ AIDS is an epidemic that is most prevalent in India affecting people of different age groups, occupations and gender. It has a severe impact on the health status of the affected individuals. With the increase in the transmission of HIV there is also an increase in the existence of TB as a co-infection. In this context, the aim of our study is to emphasize the factors affecting the occurrence, transmission and prognosis of HIV/AIDS patients along with TB co-infection.Methods: A cross sectional study was conducted from October 2015 to March 2016 at an ART center in South India. All the seropositive patients with/ without opportunistic infection above the age of 18 years were included in the study.Results: Overall 374 patients were included in the study, of which the most affected age group was 18-45 years. Women constituted 55.61% of the total population. 64.17% of the individuals were married. Majority of them belonged to rural areas (64.97%) and were illiterates (37.43%). Commonly observed WHO clinical stage was I and functional status was working. Heterosexuality (93.65%) was the predominant route of transmission. 170 had TB with PTB (60.58%) being prevalent than EPTB (33.52%). The number of smear positive and smear negative cases were 37.79% and 27.55% respectively. DOTS therapy was accessible to only 49.99%.Conclusions: There was an extensive prevalence of TB among HIV/AIDS individuals. This signifies a need for increased screening of TB among HIV seropositive individuals and vice-versa. Preventive and educational programmes should be organised to halt the transmission of HIV and to reduce the newly occurring HIV infections. V/ AIDS is an epidemic that is most prevalent in India affecting people of different age groups, occupations and gender. It has a severe impact on the health status of the affected individuals. With the increase in the transmission of HIV there is also an increase in the existence of TB as a co-infection. In this context, the aim of our study is to emphasize the factors affecting the occurrence, transmission and prognosis of HIV/AIDS patients along with TB co-infection.Methodology: A cross sectional study was conducted from October 2015 to March 2016 at an ART center in South India. All the seropositive patients with/ without opportunistic infection above the age of 18 years were included in the study.Results: Overall 374 patients were included in the study, of which the most affected age group was 18-45 years. Women constituted 55.61% of the total population. 64.17% of the individuals were married. Majority of them belonged to rural areas (64.97%) and were illiterates (37.43%). Commonly observed WHO clinical stage was I and functional status was working. Heterosexuality (93.65%) was the predominant route of transmission. 170 had TB with PTB (60.58%) being prevalent than EPTB (33.52%). The number of smear positive and smear negative cases were 37.79% and 27.55% respectively. DOTS therapy was accessible to only 49.99%.Conclusion: There was an extensive prevalence of TB among HIV/AIDS individuals. This signifies a need for increased screening of TB among HIV seropositive individuals and vice-versa. Preventive and educational programmes should be organised to halt the transmission of HIV and to reduce the newly occurring HIV infections.

A study on co-morbidities and treatment outcome based on updated definitions among tuberculosis patients registered at a tuberculosis unit, Bangalore

Background: Tuberculosis remains one of the world‘s deadliest communicable diseases and a major public health problem and is a most common opportunistic infection in people living with HIV. The treatment outcome of Tuberculosis is influenced by numerous factors of which presence of co-morbidities is one of the factors. The present study was done with following objectives, to assess the proportion of co-morbidities and treatment outcome of the Tuberculosis cases registered for DOTS treatment at the Tuberculosis unit.Methods: A Descriptive study was conducted at a Tuberculosis Unit in Bangalore with 80 subjects selected by purposive sampling satisfying inclusion & exclusion criteria. Data was collected using a pretested semi structured proforma administered to all the study subjects by trained investigators. Data regarding socio demographic profile, profile of tuberculosis, medical co-morbidities which the subjects were suffering were collected and these patients were followed up till their treatment completion and outcome of treatment was given based on new WHO definitions.Results: The present study showed that, 38 (47.50%) of the study subjects had one or the other comorbidities with chronic obstructive pulmonary disease being the most common 18(22.5%) followed by Diabetes 13(16.25%). On determining the treatment outcome of the study subjects the overall treatment success rate was 86.25% which included the cured and treatment completed subjects. However there was no statistically significant (p = 0.614) association between treatment success and presence of comorbidity.Conclusions: The cure rate among the tuberculosis patients, following DOTS therapy was found to be slightly less than the RNTCP standards.