The purpose of research is to improve the quality and effectiveness of the treatment of patients with stable angina and subclinical hypothyroidism, living in iodine deficiency regions by complex treatment of dishormonal, dismetabolic, hemodynamic and autonomic disorders and differentiated inclusion in complex therapy low doses of L-thyroxine and L-carnitine in the background of receiving potassium iodide. Use of a standard anti-ischemic therapy and potassium iodide in patients with subclinical hypothyroidism and stable angina, living in areas of iodine deficiency, does not improve the laboratory and instrumental manifestations of comorbid pathology. The combination of anti-ischemic therapy and L-thyroxine has positive influence to the improvement of the free-radical oxidation processes and heart rate variability only in the group of patients with subclinical hypothyroidism and duration less than 5 years of stable angina. In the group of patients with a disease duration of more than 5 years for achievement of the target levels of the main indicators of the free-radical oxidation processes and antioxidant defense, as well as the normalization of hemodynamic and autonomic regulation of cardiac activity appropriate to apply combined therapy using a standard anti-ischemic treatment, potassium iodide, L-thyroxine and L-carnitine. Thus, for adequate restore of the clinical condition, hemodynamic parameters and to prevent metabolic disorders in patients with stable angina and subclinical hypothyroidism it is advisable to use a differentiated combination therapy by L-thyroxine and L-carnitine with based receivement potassium iodide.