Doses Of Trimethoprim-sulfamethoxazole Research Articles

969 - Comparison of Long Term Low Dose Trimethoprim-Sulfamethoxazole and Nitrofurantoin Macrocrystals in the Treatment of Children with Recurrent Urinary Tract Infections-Results and Effect on Serum Hematologic-Hepatic-Renal Evaluation

No AccessJournal of Urology1 Jun 1987Comparison of Long Term Low Dose Trimethoprim-Sulfamethoxazole and Nitrofurantoin Macrocrystals in the Treatment of Children with Recurrent Urinary Tract Infections-Results and Effect on Serum Hematologic-Hepatic-Renal Evaluation Jeffery Wacksman, David Stewart, Paul McEnery, C. Frederic Strife, and Clark West Jeffery WacksmanJeffery Wacksman More articles by this author , David StewartDavid Stewart More articles by this author , Paul McEneryPaul McEnery More articles by this author , C. Frederic StrifeC. Frederic Strife More articles by this author , and Clark WestClark West More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)76118-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Comparison of Long Term Low Dose Trimethoprim-Sulfamethoxazole and Nitrofurantoin Macrocrystals in the Treatment of Children with Recurrent Urinary Tract Infections-Results and Effect on Serum Hematologic-Hepatic-Renal Evaluation." The Journal of Urology, 137(6), p. 346A © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 137Issue 6June 1987Page: 346A Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffery Wacksman More articles by this author David Stewart More articles by this author Paul McEnery More articles by this author C. Frederic Strife More articles by this author Clark West More articles by this author Expand All Advertisement PDF downloadLoading ...

Pseudomembranous Colitis Following Low Dose Trimethoprim-Sulfamethoxazole

A 94-year-old man had pseudomembranous colitis while taking low dose trirnethoprim-sulfamethoxazole for recurrent urinary tract infection. The suppressive effect of low dose trimethoprim-sulfamethoxazole on normal colonic flora appeared to be a factor in the development of pseudomembranous colitis in this patient.

Treatment of cystitis in women with a single dose of trimethoprim-sulfamethoxazole.

The efficacy of a single dose (four tablets) and of 10-day courses of trimethoprim-sulfamethoxazole (TMP-SMZ) was studied in 77 women with symptomatic cystitis and negative tests for antibody-coated bacteria. Cure rates after six weeks were 76% for single-dose therapy and 87% for 10 days of treatment. For Escherichia coli infections, cure rates after six weeks were 80% and 86%, respectively. However, 10-day treatment eliminated enteric bacilli from urethral and vaginal sites more often than did single-dose therapy. Two weeks after completion of treatment, perineal colonization was observed more often in the women who developed recurrent infections than in those who did not (P = 0.01). During these two weeks, recurrent infections were found somewhat more often in the women who had received single-dose therapy than in those who had undergone 10-day treatment (5 of 38 vs. 2 of 39; P = 0.07). With conventional courses of antibiotics, retreatment of all recurrent infections was less successful in women previously given single-dose therapy. Recurrent infections were also more frequent in women infected with bacteria other than E. coli. Both drug regimens were well tolerated. However, serious adverse reactions were fewer in patients treated with a single dose (8.5%) than in patients treated for 10 days (15%). Single-dose therapy with TMP-SMZ appears as effective as 10-day therapy in acute uncomplicated cystitis caused by E. coli.