Doses Of Atropine Sulfate Research Articles

Atropine toxicity in the treatment of mental disease.

The effect of repeated administrations of 32 mgms. of atropine sulfate to 183 unselected mentally ill patients has been studied. There was one death in this series. One hundred and fifty-four of these cases have been statistically analysed. Five to six months following the termination of therapy the following was found: Sixteen percent of all patients were on convalescent status, markedly improved. Sixty percent of all neurotic patients were on convalescent status, markedly improved. Twenty percent of all catatonic schizophrenic patients were on convalescent status, markedly improved. Twenty-three percent of all manic-depressive patients, manic phase, were on convalescent status markedly improved. Eleven percent of all paranoid schizophrenic patients were on convalescent status, improved. It is apparent that toxic doses of atropine sulfate are necessary to be therapeutically effective. Further investigation into pharmacotoxic therapy with other drug agents appears to be a promising field for research.

The influence of certain commonly used drugs on the rate of gastric emptying in the normal human subject as determined by an intubation technique

The gastric emptying curve of five normal human subjects as obtained by repeated aspiration, measurement and reinjection of a test solution was essentially unaltered by clinical doses of atropine sulphate, amphetamine sulphate, prostigmine, nitroglycerine, “Syntropan,” acetyl-B-methylcholine chloride, ergotamine tartrate or sodium bicarbonate. Morphine sulphate produced a delayed inhibition of gastric emptying in each of five experiments.