The origin of gamma-ray flares of blazars is still an open issue in jet physics. In this work, we reproduce the multiwavelength spectral energy distribution (SED) of flat-spectrum radio quasars 3C 454.3 under a one-zone leptonic scenario, investigate the variation of the physical parameters in different activity states, and analyze the possible origin of its γ-ray outburst. Based on the analysis of multiwavelength quasi-simultaneous observations of 3C 454.3 during MJD 55,400–56,000, we consider that the radiation includes synchrotron (Syn), synchrotron self-Compton (SSC), and external Compton (EC) radiations by the simulation, and the seed photons of the external Compton component mainly comes from the broad-line region and dusty molecular torus. The model results show that: (1) We can well reproduce the multiwavelength quasi-simultaneity SED of 3C 454.3 in various activity states by using a one-zone Syn+SSC+EC model. (2) By comparing the physical model parameters of the bright and the quiescent states, we suggest that this γ-ray flaring activity is more likely to be caused by the increase in the doppler factor.