INTRODUCTION: Safe blood donors form the backbone of safe blood transfusion services. Donor eligibility policies are a critical layer of blood safety designed to ensure selection of healthy donors and to protect recipients from any harm. This study was planned to analyze the pattern of whole blood donor deferrals, its characteristics and reasons at a tertiary care institute in Northern India, as the pattern varies according to epidemiology of diseases in different demographic areas.
 
 MATERIAL & METHODS: It was a cross sectional study of 2 years duration from December 2015 to November 2017. The data of the potential donors who were deferred was recorded on a separate proforma which included their demographic details, type of donation- voluntary donor (VD) and replacement donor (RD); first time (FT) and repeat donor (RPT); type of deferrals (permanent and temporary) and the reasons of deferrals. 
 
 RESULTS: Three thousand one hundred and thirty-three donors (voluntary-1446 and replacement-1687) donated and 597 donors were deferred (deferral rate- 16%) during this period. Majority of the deferrals i.e. 525 (88%) were temporary, 72 (12%) were permanent. The most common reason of temporary deferral was anemia. The commonest reason of permanent deferrals was a medical history of jaundice.
 
 CONCLUSION: Our study results indicate that the blood donor deferral can have subtle variations based on regional aspects that should be considered when national policies are developed as pattern of deferral varies according to epidemiology of diseases in different demographic areas.