Donor Kidney Research Articles

BK Virus Nephropathy After Kidney Transplantation and Its Diagnosis Using Urinary Micro RNA

BK virus-associated nephritis (BKVAN) is an important cause of graft loss in renal transplant recipients B K viremia occurs in up to 30% of renal transplant recipients. Since the discovery of BKV in 1971, effective prophylaxis and treatment have not been established, and it is not uncommon for a transplant kidney to be lost without cure of BKVAN. BK virus infection is reactivated when cellular immunity is suppressed, which is often during the first year after kidney transplantation when cellular immunity is most suppressed. Clinically, it is caused by reactivation of latent infection or new infection from the donor kidney, leading to viremia, viremia, and transplant nephropathy. BK virus nephropathy is currently diagnosed definitively by measuring the amount of BK virus DNA in the blood and proving SV40-positive cells in transplant kidney tissue obtained by transplant kidney biopsy, but the time required for diagnosis and the low sensitivity of immunohistochemistry using antibodies are problematic. Therefore, we investigated whether the diagnosis of BK virus nephropathy could be made earlier by searching for miRNAs in the urine of renal transplant recipients.

Long-Term Risk of ESKD in Kidney Donors with Diabetes Mellitus Using eGFR 6 Months after Donation

Long-Term Risk of ESKD in Kidney Donors with Diabetes Mellitus Using eGFR 6 Months after Donation

Quality of Life in Kidney Donors: A Single-Center Experience

Quality of Life in Kidney Donors: A Single-Center Experience

Does Live Donor and Preemptive Kidney Transplantation Reduce the Impact of Socioeconomic Deprivation on Graft Outcome?

Does Live Donor and Preemptive Kidney Transplantation Reduce the Impact of Socioeconomic Deprivation on Graft Outcome?

Pediatric Kidney Donation and Transplantation in Kingdom of Saudi Arabia.

The evolution of pediatric kidney donation and transplantation in the Kingdom of Saudi Arabia underscores the transformative effects of strategic initiatives and institutional reforms aimed at fostering self-sufficiency and ethical stewardship in transplantation. The ascendance of the Saudi Center for Organ Transplantation as a regional hub for organ procurement and transplantation is a testament to Saudi Arabia's commitment to advancing health care delivery and promoting international collaboration in combating organ trafficking and commercialism. Moving forward, sustained investments in infrastructure, capacity building, and regulatory oversight will be paramount to addressing emerging challenges and consolidating Saudi Arabia's position as a global leader in transplantation. By prioritizing patient welfare, ethical principles, and operational excellence, Saudi Arabia is poised to shape the future trajectory of pediatric kidney transplantation and usher in a new era of health care innovation and equity within the region and beyond.

Sociodemographic Correlates of Mortality after Living Kidney Donation: Informing the Need for Nondonor Controls

Sociodemographic Correlates of Mortality after Living Kidney Donation: Informing the Need for Nondonor Controls

Evolution of Biologically Related Living Kidney Donations in the United States over 35 Years

Evolution of Biologically Related Living Kidney Donations in the United States over 35 Years

Racial and Relationship Trends in Living Kidney Donation: A Retrospective Analysis from Miami Transplant Institute

Racial and Relationship Trends in Living Kidney Donation: A Retrospective Analysis from Miami Transplant Institute

Reexamining Transplant Outcomes in Acute Kidney Injury Kidneys Through Machine Learning.

Despite many people awaiting kidney transplant, kidney allografts from acute kidney injury (AKI) donors continue to be underutilized. We aimed to cluster kidney transplant recipients of AKI kidney allografts using an unsupervised machine learning (ML) approach. Using Organ Procurement and Transplantation Network-United Network for Organ Sharing (OPTN/UNOS) data, a consensus clustering cohort analysis was performed in 12356 deceased donor kidney transplant recipients between 2015 and 2019 in whom donors had a terminal serum creatinine ≥1.5mg/dL. Significant cluster characteristics were determined, and outcomes were compared. The median donor terminal creatinine was 2.2 (interquartile range [IQR] 1.7-3.3) mg/dL. Cluster analysis was performed on 12356 AKI kidney recipients, and three clinically distinct clusters were identified. Young, sensitized kidney re-transplant patients characterized Cluster 1. Cluster 2 was characterized by first-time kidney transplant patients with hypertensive and diabetic kidney diseases. Older diabetic recipients characterized Cluster 3. Clusters 1 and 2 donors were young and met standard kidney donor profile index (KDPI) criteria; Cluster 3 donors were older, more likely to have hypertension or diabetes, and meet high KDPI criteria. Cluster 1 had a higher risk of acute rejection, 3-year patient death, and graft failure. Cluster 3 had a higher risk of death-censored graft failure, patient death, and graft failure at 1 and 3 years. Cluster 2 had the best patient-, graft-, and death-censored graft survival at 1 and 3 years. Compared to non-AKI kidney recipients, the AKI clusters showed a higher incidence of delayed graft function (DGF, AKI: 43.2%, 41.7%, 45.3% vs. non-AKI: 25.5%); however, there were comparable long-term outcomes specific to death-censored graft survival (AKI: 93.6%, 93.4%, 90.4% vs. non-AKI: 92.3%), patient survival (AKI: 89.1%, 93.2%, 84.2% vs. non-AKI: 91.2%), and overall graft survival (AKI: 84.7%, 88.2%, 79.0% vs. non-AKI: 86.0%). In this unsupervised ML approach study, AKI recipient clusters demonstrated differing, but good clinical outcomes, suggesting opportunities for transplant centers to incrementally increase kidney utilization from AKI donors.

Molecular Signatures of Reperfusion in Ischemic Donor Kidneys: Distinguishing Rejection and Nonrejection Risk Genotypes through Single Nuclear RNA Sequencing

Molecular Signatures of Reperfusion in Ischemic Donor Kidneys: Distinguishing Rejection and Nonrejection Risk Genotypes through Single Nuclear RNA Sequencing

Long-Term Outcome of a Deceased Donor Kidney Transplant in a Patient with Active Chronic Lymphocytic Leukemia at Time of Transplantation

Long-Term Outcome of a Deceased Donor Kidney Transplant in a Patient with Active Chronic Lymphocytic Leukemia at Time of Transplantation

Rapid Acute Rejection with Cortical Necrosis after First-Dose Cemiplimab in a Living Donor Kidney Transplant

Rapid Acute Rejection with Cortical Necrosis after First-Dose Cemiplimab in a Living Donor Kidney Transplant

Adjusted Donor-Age (ADA) Score as a Tool for Characterizing Deceased Donor Kidneys: Multicentre Validation Study for a German Eurotransplant Cohort

Adjusted Donor-Age (ADA) Score as a Tool for Characterizing Deceased Donor Kidneys: Multicentre Validation Study for a German Eurotransplant Cohort

Donor kidney assessment by robotic optical coherence tomography

Donor kidney assessment by robotic optical coherence tomography

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits in a Patient with Recent Deceased Donor Kidney Transplant Successfully Treated with Rituximab Monotherapy

Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits in a Patient with Recent Deceased Donor Kidney Transplant Successfully Treated with Rituximab Monotherapy

Single-Center Short-Term Outcomes in Recipients of Deceased Donor Kidneys with AKI

Single-Center Short-Term Outcomes in Recipients of Deceased Donor Kidneys with AKI

Graft Kidney Artery Stenosis in a Deceased Donor Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: A Case Report

Graft Kidney Artery Stenosis in a Deceased Donor Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease: A Case Report

Social Network Interventions to Reduce Racial/Ethnic Living Donor Kidney Transplants (LDKT) Disparities: Preliminary Results from the Friends and Family of Kidney Transplant Patients Study

Social Network Interventions to Reduce Racial/Ethnic Living Donor Kidney Transplants (LDKT) Disparities: Preliminary Results from the Friends and Family of Kidney Transplant Patients Study

Time Course of Glycolytic Control Protein Expression in Urinary Extracellular Vesicles (UEV) of Deceased Donor Kidney Transplant Recipients

Time Course of Glycolytic Control Protein Expression in Urinary Extracellular Vesicles (UEV) of Deceased Donor Kidney Transplant Recipients

Racial Disparities in Access to Deceased Donor Kidney Transplantation in the United States, 1999-2023

Racial Disparities in Access to Deceased Donor Kidney Transplantation in the United States, 1999-2023