Domino Ring-Opening Cyclization Research Articles

Domino‐Ring Opening‐Cyclization (DROC) of Donor‐Acceptor (DA) Cyclopropanes

AbstractA new concept called “domino‐ring opening‐cyclization (DROC)” has been introduced by us where both the reactive centres of the DA cyclopropane participate in the bond formation, with a suitable reagent bearing both nucleophilic and electrophilic terminals in a domino fashion. The present review is intended to concisely describe the evolution of this new concept.

ChemInform Abstract: Enantioselective Synthesis of 4,5‐Dihydropyrroles via Domino Ring‐Opening Cyclization (DROC) of N‐Activated Aziridines with Malononitrile.

An efficient and practical strategy for the synthesis of highly functionalized racemic and non-racemic 4,5-dihydropyrroles via domino ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and stereoselectivity is described. The reaction serves as a tool for the synthesis of a large variety of substituted 4,5-dihydropyrroles in enantiomerically pure forms.

Enantioselective Synthesis of 4,5-Dihydropyrroles via Domino Ring-Opening Cyclization (DROC) of N-Activated Aziridines with Malononitrile

An efficient and practical strategy for the synthesis of highly functionalized racemic and non-racemic 4,5-dihydropyrroles via domino ring-opening cyclization (DROC) of activated aziridines with malononitrile in excellent yield and stereoselectivity is described. The reaction serves as a tool for the synthesis of a large variety of substituted 4,5-dihydropyrroles in enantiomerically pure forms.