Dominant Megacolon Research Articles

A high-resolution genetic map of mouse Chromosome 15 encompassing the Dominant megacolon (Dom) locus

Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.

Association of megacolon with a new dominant spotting gene (Dom) in the mouse.

A new semidominant mutation in the mouse is described. In heterozygotes it produces white spotting and a deficiency of myenteric ganglion cells in the colon and, in homozygotes it is lethal prior to 13 days of gestation. The mutation, called dominant megacolon, symbol Dom, is located on chromosome (chr) 15, 20.6 +/- 1.6 units proximal to Ca. Hairy ears, Eh, a semidominant gene also on chr 15 is shown to have a suppressing effect on crossing over in this section of chr 15.