Dominant Form Research Articles

Re-theorising namûs beyond ‘honour’: self-making, feminist agency and global epistemic justice

Namûs describes a ‘way of life’ integral to Kurdish sociality and to the sense of self for many Kurds who live it in a plurality of ways. Constituting a form of power over the subject which can potentially take the form of domination, namûs is also a social relation of care and power between subjects and is integral to its subject's ethical relationship of self-to-self and processes of self-making. Post-Enlightenment and liberal frameworks of ‘modern’ selfhood, however, have tended to render namûs equivalent to ‘honour’ and ‘honour-based violence’ (‘HBV’). Through this act of mistranslation, a life with namûs is constructed as violent, unworthy, racially inferior and harmful to women. Building upon multi-sited ethnographic fieldwork conducted in North Kurdistan, Turkey and Denmark, this article originally theorises namûs as a practice of ethical self-making that is epistemic, dignified and agentic in all its complexities. Women living with and through namûs actively work to cultivate this way of being, thereby interrupting the epistemic authority of liberal feminism. Namûs, this article argues, cannot be understood through blanket explanations of ‘crime’, ‘oppression’ and ‘patriarchy’, as the discourse on ‘honour’ would suggest. Breaking away from these injurious portrayals is, therefore, vital to realise global epistemological justice.

Auxin co-receptor IAA17/AXR3 controls cell elongation in Arabidopsis thaliana root solely by modulation of nuclear auxin pathway.

The nuclear TIR1/AFB-Aux/IAA auxin pathway plays a crucial role in regulating plant growth and development. Specifically, the IAA17/AXR3 protein participates in Arabidopsis thaliana root development, response to auxin and gravitropism. However, the mechanism by which AXR3 regulates cell elongation is not fully understood. We combined genetical and cell biological tools with transcriptomics and determination of auxin levels and employed live cell imaging and image analysis to address how the auxin response pathways influence the dynamics of root growth. We revealed that manipulations of the TIR1/AFB-Aux/IAA pathway rapidly modulate root cell elongation. While inducible overexpression of the AXR3-1 transcriptional inhibitor accelerated growth, overexpression of the dominant activator form of ARF5/MONOPTEROS inhibited growth. In parallel, AXR3-1 expression caused loss of auxin sensitivity, leading to transcriptional reprogramming, phytohormone signaling imbalance and increased levels of auxin. Furthermore, we demonstrated that AXR3-1 specifically perturbs nuclear auxin signaling, while the rapid auxin response remains functional. Our results shed light on the interplay between the nuclear and cytoplasmic auxin pathways in roots, revealing their partial independence but also the dominant role of the nuclear auxin pathway during the gravitropic response of Arabidopsis thaliana roots.

THE CONTESTATION OF CANING AND IMPRISONMENT FOR SEXUAL HARASSMENT: TRACING THE ROOTS OF JUDGES’ LEGAL CONSIDERATIONS IN ACEH, INDONESIA

Qanun Jinayat or the Islamic Criminal Code in Aceh responds to sexual violence by stipulating norms for caning, imprisonment, and fines for offenders of these types of crimes. This is a positive effort in combating sexual crime which has become a global problem. However, at the technical level, especially in court, the ideals of justice for victims, offenders, and the community, are "disturbed" by the emergence of normative contestations between caning and imprisonment. This paper, thus, dissects the reality of the contestation referred to the judge’s decision in the Court of Appeals, the factors that influence the judge’s verdict and its implications for the protection of victims. Primary data is the decisions of the Mahkamah Shar`iyah (Religious Court) at the first level, appeals and cassation for 2016-2020, while secondary data is in the Qanun Jinayat and other Aceh local qanuns. The data is tabulated in such a way as to find the dominant form of punishment, including all offenses regulated by the Qanun Jinayat and forms of caning and imprisonment which are continued at the Court of Appeal to find possible changes in the form of punishment from the Court of First Instance. Data were analyzed using the concepts of norm contestation, judges' legal considerations, and legal protection for victims of sexual violence. The findings revealed that the contestation occurred due to legal, extra legal and regulatory dualism scenarios. This has further triggered latent contestation of authority. As a result, victims of sexual violence crimes, especially children, have not received proper protection. Hence, further studies and specific stakeholder policies are needed.

The CAPN3 p.Lys 254del variant is not always associated with dominant CAPN3-related muscular dystrophy.

Limb-girdle muscular dystrophy R1 (LGMDR1) calpain 3-related usually presents as a recessively transmitted weakness of proximal limb-girdle muscles due to pathogenic variants in the CAPN3 gene. Pathogenic variants in this gene have also been found in patients with an autosomal dominantly inherited transmission pattern (LGMDD4). The mechanism underlying this difference in transmission patterns has not yet been elucidated. Camptocormia, progressive limb weakness, myalgia, back pain, and increased CK levels are common clinical features associated with dominant forms. The p.Lys254del pathogenic variant was associated with camptocormia in two LGMDD4 families. This study aimed to present carriers found in recessively transmitted LGMDR1 families bearing the p.Lys254del variant that do not show muscle weakness. DNA sequencing was performed on exon 5 of CAPN3 in family members to establish the carrier status of the pathogenic variant. They were evaluated clinically and MRI was performed when available. Two families presented with the p.Lys254del pathogenic variant in a homozygous or compound heterozygous state. Family members carrying only the pathogenic variant in the heterozygous state did not demonstrate the myopathic characteristics described in dominant patients. Camptocormia and other severe clinical symptoms were not observed. We conclude that the p.Lys254del pathogenic variant per se cannot be solely responsible for camptocormia in dominant patients. Other undisclosed factors may regulate the phenotype associated with the dominant inheritance pattern in CAPN3 pathogenic variant carriers.

RP1 Dominant p.Ser740* Pathogenic Variant in 20 Knowingly Unrelated Families Affected by Rod-Cone Dystrophy: Potential Founder Effect in Western Sicily.

Background and Objectives. Retinitis pigmentosa (RP) is the most common inherited rod-cone dystrophy (RCD), resulting in nyctalopia, progressive visual field, and visual acuity decay in the late stages. The autosomal dominant form (ADRP) accounts for about 20% of RPs. Among the over 30 genes found to date related to ADRP, RP1 pathogenic variants have been identified in 5-10% of cases. In a cohort of RCD patients from the Palermo province on the island of Sicily, we identified a prevalent nonsense variant in RP1, which was associated with ADRP. The objective of our study was to analyse the clinical and molecular data of this patient cohort and to evaluate the potential presence of a founder effect. Materials and Methods. From 2005 to January 2023, 84 probands originating from Western Sicily (Italy) with a diagnosis of RCD or RP and their relatives underwent deep phenotyping, which was performed in various Italian clinical institutions. Molecular characterisation of patients and familial segregation of pathogenic variants were carried out in different laboratories using Sanger and/or next-generation sequencing (NGS). Results. Among 84 probands with RCD/RP, we found 28 heterozygotes for the RP1 variant c.2219C>G, p.Ser740* ((NM_006269.2)*, which was therefore significantly prevalent in this patient cohort. After a careful interview process, we ascertained that some of these patients shared the same pedigree. Therefore, we were ultimately able to define 20 independent family groups with no traceable consanguinity. Lastly, analysis of clinical data showed, in our patients, that the p.Ser740* nonsense variant was often associated with a late-onset and relatively mild phenotype. Conclusions. The high prevalence of the p.Ser740* variant in ADRP patients from Western Sicily suggests the presence of a founder effect, which has useful implications for the molecular diagnosis of RCD in patients coming from this Italian region. This variant can be primarily searched for in RP-affected subjects displaying compatible modes of transmission and phenotypes, with an advantage in terms of the required costs and time for analysis. Moreover, given its high prevalence, the RP1 p.Ser740* variant could represent a potential candidate for the development of therapeutic strategies based on gene editing or translational read-through therapy for suppression of nonsense variants.

AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis

IntroductionObesity and imbalance in lipid homeostasis contribute greatly to heart failure with preserved ejection fraction (HFpEF), the dominant form of heart failure. Few effective therapies exist to control metabolic alterations and lipid homeostasis. ObjectivesWe aimed to investigate the cardioprotective roles of AdipoRon, the adiponectin receptor agonist, in regulating lipid accumulation in the two-hit HFpEF model. MethodsHFpEF mouse model was induced using 60 % high-fat diet plus L-NAME drinking water. Then, AdipoRon (50 mg/kg) or vehicle were administered by gavage to the two-hit HFpEF mouse model once daily for 4 weeks. Cardiac function was evaluated using echocardiography, and Postmortem analysis included RNA-sequencing, untargeted metabolomics, transmission electron microscopy and molecular biology methods. ResultsOur study presents the pioneering evidence that AdipoR was downregulated and impaired fatty acid oxidation in the myocardia of HFpEF mice, which was associated with lipid metabolism as indicated by untargeted metabolomics. AdipoRon, orally active synthetic adiponectin receptor agonist, could upregulate AdipoR1/2 (independently of adiponectin) and reduce lipid droplet accumulation, and alleviate fibrosis to restore HFpEF phenotypes. Finally, AdipoRon primarily exerted its effects through restoring the balance of myocardial fatty acid intake, transport, and oxidation via the downstream AMPKα or PPARα signaling pathways. The protective effects of AdipoRon in HFpEF mice were reversed by compound C and GW6471, inhibitors of AMPKα and PPARα, respectively. ConclusionsAdipoRon ameliorated the HFpEF phenotype by promoting myocardial fatty acid oxidation, decreasing fatty acid transport, and inhibiting fibrosis via the upregulation of AdipoR and the activation of AdipoR1/AMPKα and AdipoR2/PPARα-related downstream pathways. These findings underscore the therapeutic potential of AdipoRon in HFpEF. Importantly, all these parameters get restored in the context of continued mechanical and metabolic stressors associated with HFpEF.

Capitalism and the Organization of Displacement: Selma James’s Internationalism of the Unwaged

As political theorists explore work beyond traditional workplaces, how should we understand the vast class of insecure, informal, and unsalaried workers whose existence defies traditional categories of employment? In asking this question, I revisit the political theory of the Marxist feminist and cofounder of the International Wages for Housework movement, Selma James, to explore her “internationalism of the unwaged” and her writings on wagelessness. An example of political theory in service of struggle, James’s internationalism was widely circulated in anticolonial, Black radical, and autonomous Marxist circles in the 1970s. In this article, I argue that it was grounded in three intertwined and mutually reinforcing arguments: an account of how capitalist life is spatially divided into distinct workplaces; an anticapitalist theory of identity that explains social difference as maintained by the international division of labor and labor market hierarchies; and a diagnosis of work organization viewed from the perspective of the wageless worker. I trace how James developed these arguments about the spatial division of labor, hierarchies of identity, and internationalist political struggle and how her view of the common exploitation and division of workers formed the basis of a class-struggle identity politics. Her political theory was an important contribution to women’s international thought and transnational feminist critiques of global forms of domination and exploitation. It also offers a critique of capitalism’s organization of the displacement of work and workers and an account of wagelessness as a work situation, both of which illuminate capitalist organization of work and wageless life today.

Poison in the water: Arsenic's silent assault on fish health.

Arsenic occurs across the world in freshwater and marine environments, menacing the survival of aquatic organisms. Organic and inorganic forms of this substance can be found, in which the inorganic form is more hazardous than the organic form. Most aquatic bodies contain inorganic arsenic species, but organic species are believed to be the dominant form of arsenic in the majority of fish. Natural and anthropogenic both are the sources of water contamination with arsenic. Its bioaccumulation and transfer from one trophic level to another in the aquatic food chain make arsenic a vital environmental issue. Continuous exposure to low concentrations of arsenic in aquatic organisms including fish leads to its bioaccumulation, which may affect organisms of higher trophic levels including large fishes or humans. Humans can be exposed to arsenic through the consumption of fish contaminated with arsenic. Hence, the present review facilitates our understanding about sources of arsenic, its bioaccumulation, food chain transfer, and its effect on the fish health. Also, "Poison in the Water: Arsenic's Silent Assault on Fish Health" serves as a wake-up call to recognize the pressing need to address arsenic contamination in water bodies. By understanding its devastating impact on fish health, we can strive to implement sustainable practices and policies that safeguard our precious aquatic environments and ensure the well-being of both wildlife and human communities that depend on them.

Study of PM2.5 particles in the Gucheng, North China Plain: Morphology, mixing state, and source apportionment

The PM2.5 samples were collected at regular intervals from April to October 2017 at a meteorological station in Gucheng (GC) (39.08。 N, 115.44。E), Hebei Province, China. An important site in the North China Plains (NCP). The internal composition, mixing state, and elemental mapping were determined by scanning electron microscope (SEM) and Transmission electron microscope in scanning mode (STEM). Several core-shell (C–S) structures had sulfate and nitrate shells with mineral and sea salt cores, indicating particle aging and distant transport. The major water-soluble ions (WSIs) found were NH4+, Na+, K+, Ca2+, Mg2+, Br−, Cl−, NO2−, NO3−, PO43− and SO42−. The three most dominant ions were NH4+, NO3−, and SO42−, with an average concentration of 16.02, 14.90, and 11.03 μg/m3, respectively, accounting for more than 80% of the total WSIs in PM2.5. Ion balance measurements showed that the PM2.5 were slightly acidic. [NO3−/SO42−] ratio of 1.11 shows a slightly high contribution from the mobile sources. The sea salt contribution was investigated by the molar ratio Cl−/Na+, which was slightly higher (1.9) than that for seawater (1.7), indicating an additional source, other than sea salt, for Cl− and Na+. The SOR was higher at all temperatures than NOR; SOR was strongly correlated with temperature, indicating gas-phase oxidation of SO2 to SO42− by OH radicle. The SO42− being positively correlated with NH4+ suggests NH4HSO4 and (NH4)2SO4 to be the dominant forms of SO42− present. Based on the internal structure, principal component analysis (PCA), and positive matrix factorization (PMF) analysis, the major sources of sulfate were industrial emissions from the surrounding cities, also confirmed by the Hysplit backward trajectory analysis. Nitrates arise mainly from local vehicular and industrial emissions and ammonia from fertilizers and animal manure. The local emissions and the regional transport from Shanxi, Shaanxi, Tianjin, Beijing, and Inner Mongolia were the main contributors to PM2.5 particles.

Effects of intensive oyster farming on nitrogen speciation in surface sediments from a typical subtropical mariculture bay

The spatial-temporal distributions of various nitrogen (N) species in surface sediments were examined in a typical subtropical mariculture bay (Maowei Sea) in the northern Beibu Gulf to assess the impact of intensive oyster culture activities on sedimentary N speciation. The results indicated that the mean contents of total nitrogen (TN), extractable (labile) nitrogen (LN) and residual nitrogen (RN) in the surface sediments were 33.3 ± 15.5 μmol g−1, 13.8 ± 1.3 μmol g−1 and 19.5 ± 15.0 μmol g−1, respectively, which lacked significant seasonal variability (P > 0.05). Four forms of LN, namely ion extractable form (IEF-N), weak acid extractable form (WAEF-N), strong alkali extractable form (SAEF-N) and strong oxidant extractable form (SOEF-N) were identified based on sequential extraction. SOEF-N was the dominant form of LN, accounting for 67.8 ± 2.5 % and 63.7 ± 5.9 % in summer and winter, respectively. Spatially, the contents of sedimentary TN, LN, RN, WAEF-N and SOEF-N in intensive mariculture areas (IMA) were significantly higher than those in non-intensive mariculture areas (NIMA) during summer (P < 0.05). Stable nitrogen isotope (δ15N) mixing model revealed that shellfish biodeposition was the predominant source of sedimentary TN in IMA with a contribution of 67.8 ± 23.0 %, approximately 5.4 times that of NIMA (12.6 ± 3.3 %). Significant positive correlations (P < 0.05) were observed between most forms of N species (WAEF-N, SOEF-N, LN and RN) and shellfish-biodeposited N in the surface sediments during summer, indicating that intensive oyster farming greatly enhanced sedimentary TN accumulation.

National Autonomy and the Phenomena of Neo-Colonialist Activities

The economic penetration of the developing states has become a competitive replacement for colonialism. Thus, National autonomy– the capacity of a nation–state to make and apply decisions shaping its political and economic future, has significantly been subjugated by neocolonialism- the determinations of the former colonial and new powers to maintain control over independent developing states. The peripheral states have become satellites of the center nations as their economies have been structured to serve international capitalism. The aim of this work is to place the relationship between the neo-colonialist activities and the national autonomies of the developing states. The paper adopted the survey research design. The instrument for data collection was structured questionnaire while the simple linear regression analysis was used to examine the extent of the relationship that exist between the variables. The two hypotheses were tested at 0.05 level of significance. Findings revealed that there exists a significant relationship between national autonomy and the phenomena of neo-colonialist activities, and that though colonialism may virtually be dead, but neo-colonialism continues as the 3rd world states have become victims of a subtle form of domination. The work recommends that autonomy should include choosing to orient economic and political decisions of the nation-state instead of the continues political hegemony and economic exploitation by the advanced states. Therefore, the developing states must be constructive in their relations with the advanced nations and ensure the respect and enhancement of local autonomy. African states; as Timamy postulated, should promote self-esteem, institutionalize human dignity and entrench the values of integrity. The leaders must realize that the present world order is part of the problem and not; in any way, the solution to Africa’s unending nightmare.

Functional characterization of variants found in Japanese patients with hereditary hemorrhagic telangiectasia.

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant form of vascular dysplasia. Genetic diagnosis is made by identifying loss-of-function variants in genes, such as ENG and ACVRL1. However, the causal mechanisms of various variants of unknown significance remains unclear. In this study, we analyzed 12 Japanese patients from 11 families who were clinically diagnosed with HHT. Sequencing analysis identified 11 distinct variants in ACVRL1 and ENG. Three of the 11 were truncating variants, leading to a definitive diagnosis, whereas the remaining eight were splice-site and missense variants that required functional analyses. In silico splicing analyses demonstrated that three variants, c.526-3C > G and c.598C > G in ACVRL1, and c.690-1G > A in ENG, caused aberrant splicing, as confirmed by a minigene assay. The five remaining missense variants were p.Arg67Gln, p.Ile256Asn, p.Leu285Pro, and p.Pro424Leu in ACVRL and p.Pro165His in ENG. Nanoluciferase-based bioluminescence analyses demonstrated that these ACVRL1 variants impaired cell membrane trafficking, resulting in the loss of bone morphogenetic protein 9 (BMP9) signal transduction. In contrast, the ENG mutation impaired BMP9 signaling despite normal cell membrane expression. The updated functional analysis methods performed in this study will facilitate effective genetic testing and appropriate medical care for patients with HHT.

Stakeholder Participation in Strategic Environmental Assessment of the Detailed Spatial Plan for Manokwari Urban Area, Papua Barat, Indonesia

Regional development as an effort to improve human welfare always has an impact on the environment. Therefore, this research aims to determine stakeholder participation in Strategic Environmental Assessment (SEA) of Detailed Spatial Plan (DSP) for the Manokwari Regency Urban Area. The research was carried out from February to March 2021, where the research location in the Manokwari Urban Area which is the location for the delineation of DSP. Data collection was carried out by means of observation, interviews and secondary data studies. Observations were carried out directly during the discussion of SEA documents. The researcher describes in detail about the conditions in the field, human activities and the context in which the activities were held. Interviews were conducted by asking written questions to respondents and using prepared questionnaires. Data was analyzed using a stakeholder analysis approach to ensure aspects, including: a) determining precisely the parties that will be involved; b) guarantee the implementation of the principle of participation; c) guarantee that the results of the DSP document obtain public legitimacy; d) level of stakeholder participation. The research results show that the most dominant form of stakeholder participation is the contribution of input/suggestions and the provision of information/data from stakeholders. This means that there is a willingness and ability of the stakeholders involved to express their opinions scientifically. Stakeholders' willingness to participate can increase motivation to make changes, while the ability to participate is related to human resources and learning abilities.

Evaluate Human Perception of the Built Environment in the Metro Station Area

Transit-oriented development (TOD) has become a dominant form of spatial planning and land use in large cities internationally. As the intersections of urban space and rail transportation, metro station areas play a key public service function in the lives of city residents. Based on the “5D” index and Node-Place theory in the metro station area, current research on the built environment in metro station areas focuses on improving the economic and transportation efficiency while neglecting public perception of the construction of station space. Sentiments, as an important part of the individual’s perception, are closely related to the built environment. Therefore, this study takes 187 metro stations within the fifth ring road of Beijing, China, as an example and extracts public sentiment information from social media data using a wide range of natural language processing techniques to quantitatively analyze the distribution of the public’s sentiment characteristics (including intensity, polarity, and category) in the metro station area and deeply explores the spatial correlation with the distribution of the objective built environment elements. The study shows that influenced by the spatial design of the metro station, density, land use functions, etc., the sentiment intensity of the station area within the Fifth Ring Road of Beijing is “strong in the east and weak in the west, strong in the north and weak in the south”, and the sentiment polarity has the characteristic of gradually negative from inside to outside in a circular pattern. Synthesizing the sentiment perception in the metro station area, our study further divided the Beijing metro station area into four major categories and eight specific subtypes.

Unraveling the role of bacterial communities in mangrove habitats under the urban influence, using a next-generation sequencing approach

Mangrove ecosystems are vital coastal habitats with rich biodiversity and play a significant role in carbon sequestration, these habitats are facing mounting threats from rapid urbanization. This study delves into assessing the sediment bacterial communities from the urban mangrove habitats of Campal and Panaji, within the Mandovi estuarine environment of Goa, to understand the intricate interplay between urbanization and bacterial dynamics in the mangrove habitats. We used a combined approach of 16S amplicon and shotgun sequencing methodologies to understand the bacterial taxonomic composition and functional profiles. The community structure revealed the dominance of bacterial groups from phylum Proteobacteria, Chloroflexi and Actinobacteria at both locations. The impact of urbanization was evident from the increased abundance of pathogenic groups at class and genus levels in this region. The core microbiome analysis showed the presence of Shewanella, Pseudomonas and Clostridium which are mostly pathogenic, anaerobic taxa Woeseia, Rheinheimera, like genera that are involved in the organic matter cycling and unclassified bacteria. Though increased pathogenic forms are reported, it is evident that the dominant taxa also included groups that contributed to the biogeochemical cycling of organic matter in sediment from these locations. Functional diversity elucidated through shotgun metagenomics analysis showcased the predominance of carbohydrate metabolism and the presence of glycoside hydrolases degrading plant-based starch, pectin and cellulosic organic matter. The occurrence of xenobiotic biodegradation pathways is an indication of the presence of xenobiotic degrading microbes as a natural means of degrading high amounts of pollutants at this location. Comparative analysis of the metagenomes from this study with similar earlier studies at Ribandar, Mandovi and Cortalim, Zuari mangrove habitats of Goa with varying pollution levels also reiterates the terrestrial influence on the microbial community in these habitats. It showed that Panaji and Campal locations had the presence of dominant pathogenic forms which was absent in the other two locations. The Ribandar and Coratlim location which is reported to have a comparatively lesser impact due to anthropogenic activity had an increased abundance of distinct genera which are predominant heterotrophic forms involved in remineralization and reduced levels of pathogens. Our findings highlight the profound influence of urbanization on the sediment mangrove bacterial communities and spotlight the resilience and adaptability of these microorganisms. This calls for immediate action and preventive measures to restore their functional potential in maintaining the health of these ecosystems amidst expanding urban landscapes.

An Exploring Obstacles and Teaching Strategies Used by Main Character in “Like Stars on Earth” Movie

Speech act study is important for our daily because it gives a comprehension of what message is discovered in every utterance. Austin (1962) stated that in uttering a sentence, a speaker is generally involved in three levels of speech acts, they are locutionary act, illocutionary act, and perlocutionary act. This study focuses on analyzing illocutionary acts in “Like Stars on Earth” movie. This movie teaches teachers and parents in the world about how to understand the aptitudes and limitations of a child. This study used descriptive qualitative method within the framework of applied linguistics, i.e., discourse analysis. In collecting data, the writer was watching and observing the utterances of dialogues in a movie. The writer selected the data from the characters’ utterances which are related to the topic, especially about illocutionary speech acts to the data sheet. Then, categorizing the data into types of illocutionary speech acts. This study was taking the appropriate utterances and omitting inappropriate utterances. There were 359 utterances found in the utterances that uttered by the main character in this movie. Types of illocutionary acts were directive 195 times, representative 106 times, expressive 39 times, declarative 7 times, and commisive 12 times. From the total of the data above, the directives act served as the dominant form among the five types of illocutionary acts. It shows that the main character often gives expression to the hearer to do something.

Heart Failure with Preserved Ejection Fraction: The Pathophysiological Mechanisms behind the Clinical Phenotypes and the Therapeutic Approach.

Heart failure (HF) with preserved ejection fraction (HFpEF) is an increasingly frequent form and is estimated to be the dominant form of HF. On the other hand, HFpEF is a syndrome with systemic involvement, and it is characterized by multiple cardiac and extracardiac pathophysiological alterations. The increasing prevalence is currently reaching epidemic levels, thereby making HFpEF one of the greatest challenges facing cardiovascular medicine today. Compared to HF with reduced ejection fraction (HFrEF), the medical attitude in the case of HFpEF was a relaxed one towards the disease, despite the fact that it is much more complex, with many problems related to the identification of physiopathogenetic mechanisms and optimal methods of treatment. The current medical challenge is to develop effective therapeutic strategies, because patients suffering from HFpEF have symptoms and quality of life comparable to those with reduced ejection fraction, but the specific medication for HFrEF is ineffective in this situation; for this, we must first understand the pathological mechanisms in detail and correlate them with the clinical presentation. Another important aspect of HFpEF is the diversity of patients that can be identified under the umbrella of this syndrome. Thus, before being able to test and develop effective therapies, we must succeed in grouping patients into several categories, called phenotypes, depending on the pathological pathways and clinical features. This narrative review critiques issues related to the definition, etiology, clinical features, and pathophysiology of HFpEF. We tried to describe in as much detail as possible the clinical and biological phenotypes recognized in the literature in order to better understand the current therapeutic approach and the reason for the limited effectiveness. We have also highlighted possible pathological pathways that can be targeted by the latest research in this field.

The detailed profile of congenital heart diseases in 254 children with Down syndrome in Saudi Arabia

BackgroundDown syndrome is the most common chromosomal abnormality in humans. It is associated with several congenital anomalies, including a spectrum of congenital heart diseases. Understanding the true prevalence and distribution of congenital heart diseases is essential for health resource planning, outcomes, and family counseling.This study aimed to assess the prevalence and distribution of congenital heart disease in children with Down syndrome. It is a retrospective cohort review that included all patients treated at King Abdulaziz University Hospital. Frequencies were estimated using the SPSS software and comparisons were made using Student’s t test.ResultsThe ages of the 254 subjects ranged from less than 1 year to 53 years. Of these, 44.5% were female and 40.6% were Saudi nationals. Congenital heart disease was present in 66.5% with a significant difference between Saudi nationals 44.6%) and non-Saudi nationals 71.5% (P = 0.01). The atrioventricular septal defect was the most common pathology, representing 33.1% of all congenital heart diseases followed by perimembranous ventricular septal defect 18.9%, and right ventricular pathology 10.2%.ConclusionThe prevalence of congenital heart diseases in Saudi children with Down Syndrome is similar to that reported worldwide. Septal defects and right-sided pathologies are the dominant forms of congenital heart diseases, with atrioventricular septal defect and perimembranous ventricular septal defect representing the most common pathologies.

Whimsical criticism

ABSTRACT For many decades, Virginia Woolf's reputation in the history of literary criticism has been as a heroic rebel and challenger to the dominant forms and institutions of literary criticism. This legacy has rightfully been celebrated. Yet this view tends to treat Woolf's idiosyncratic and whimsical writings in relation to and in opposition to the prevailing standards of academic criticism rather than as a serious, normatively coherent form of criticism in its own right. Thus, this essay takes up the hypothesis that Woolf's critical writing constitutes a methodologically coherent criticism, even while it understands the values of reading and literature in deeply different terms. Taking up Woolf's whimsical criticism offers an important alternative practice of criticism capable of mediating between professional and everyday forms of reading. Pursuing Woolf's criticism also allows the essay to unfold some of the values that subtend and continue to shape the hidden norms of literary criticism today.

Ethnobotanical study of medicinal plants used by the indigenous community of the western region of Mizoram, India

BackgroundPlants have long been utilized as traditional medicines by the inhabitants. However, until recently, the traditional knowledge had not been extensively documented from the hilly state of Mizoram, India. The present study was designed to perform a quantitative analysis of ethnomedicinal plants used by Mizo tribes using quantitative ethnobotanical indices. The study attempts to find new ethnomedicinal plant species that could be a source for the discovery of new drug formulations.MethodsThe information was obtained through extensive and semi-structured interviews. Quantitative indices such as informant consensus factor (ICF), use value (UV), fidelity level (FL), relative frequency of citation (RFC), and relative importance index (RI) were used to quantify the advantages, significance, and coverage of ethnomedicine. All the collected data were analyzed using the ethnobotanyR package in R.ResultsA total of 124 ethnomedicinal plant species, distributed in 112 genera under 60 families, were documented from 206 informants. Herbs (49.19%) were the most dominant growth form, and leaves (49.19%) were the most common plant parts used for the preparation of herbal medicine while decoction (61.21%) was the most popular formulation. Asteraceae (11) were the most common families among the documented species. Digestive disease, burns, cuts, and wounds had the highest ICF value (0.94), and Lepionurus sylvestris had the highest FL (91%). Oroxylum indicum (6.25) was the most commonly utilized ethnomedicinal plant based on UV, RI had the highest value in Blumea lanceolaria (1.12), and O. indicum (0.29) had the highest RFC value. According to the findings, the traditional medicinal plant treatment is still widely used in the research area.ConclusionDocumentation of new ethnomedicinal species and their therapeutic usage will encourage further phytochemical and pharmacological research, potentially leading to the discovery of new drug formulations.