The Cold-Formed Steel (CFS) construction in seismic regions requires carefully selecting and designing an approved seismic-force resisting system. Among the available seismically-resistant structural systems, the bolted CFS moment frames have recently gained some attention. However, given the currently existing design issues associated with the bolted connections in CFS moment frames, this paper seeks to conduct a numerical investigation into the potential substitution of bolt fasteners with the weld materials in CFS frames. The objective is to explore the possibility of including the welded connection as an alternative to bolted connections in subsequent editions of the ASCE 7 code. To this end, finite element models, consisting of two built-up CFS beams and twenty-three flare-bevel-groove and fillet weld specimens, are initially validated against the cyclically and monotonically loaded tests with data available in the relevant literature. Subsequently, the verified weld and CFS beam models are incorporated in the simulation of thirty-four CFS beam-to-column welded moment connections, each differing in beam dimension, weld length and size, and gusset plate thickness. The built-up beams comprise back-to-back and lip-to-lip double C-section profiles. Stress variations along the weld lines, derived initially from nonlinear finite element analyses and then computed from the theoretical elastic analysis, are compared to establish a basis for categorizing stress distribution patterns in the longitudinal welds. Finally, six CFS frames assembled with the welded moment connection and subjected to a combined column axial compression and cyclic lateral drift are examined, resulting in an estimated seismic modification coefficient, R, equal to 3.8. Overall, the welded moment connections demonstrate a stable seismic response with an average ductility ratio, μ, of 2.7. The dominant failure mode is a locally developed ductile fracture in the two end segments of the longitudinal welds, identified as critical regions.