Dominant Effect Research Articles

Categorization of Spatial and Temporal Ejecta Outcomes in Binary Systems Based on Variations of the Didymos System

With the increasing number of binary asteroid systems being discovered, ejecta studies must expand from solely investigating single-body systems to modeling more complex multiple-body systems. For example, the Double Asteroid Redirection Test provides an opportunity to study the dynamics of a debris cloud around Didymos and Dimorphos, a near-Earth binary asteroid system. Here we simulate 72 variations on the Didymos system in order to categorize types of ejecta outcomes and analyze the influence of the varying system parameters on each outcome. We have varied five parameters: the system separation, the mass ratio between the two bodies, the impact location, the target-body shape, and the target-body rotation period. The resulting provenance maps of the final ejecta distributions were blindly sorted into five categories, while the resulting cumulative distribution functions (CDFs), describing the rate at which particles hit the surface, were blindly sorted into eight categories. We count the occurrences of the parameter values in each of the categories and apply a Cramer’s V statistical test to evaluate the significance of the association between each varied effect and the overall grouping of the provenance maps and CDFs. We conclude that more dominant effects, such as a small rotation period, produce notably similar ejecta distributions that result in being assigned to the same category. Less dominant effects, such as target-body location, are sorted into several categories due to the larger influence of varying dominant effects.

Impacts of bamboo dominance and die‐off on seedling dynamics in a tropical secondary forest (Brazil)

AbstractAulonemia aristulata is a tropical bamboo species of mixed rhizome type and monocarpic flowering that can become super‐dominant after anthropogenic disturbances in tropical forests. The synchronized reproductive events of flowering and die‐off of monocarpic bamboo systems provide a rare opportunity to evaluate the temporal effects of bamboo dominance on forest regeneration. To evaluate the effects of bamboo dominance on forest regeneration, we compared the structure (abundance, richness, composition) and dynamics (mortality, recruitment, survival and growth) of tree and shrub seedling communities from two non‐contiguous forests stands (bamboo‐dominated vs. non‐dominated sites) for 2 years, before and after a synchronized reproductive event. Bamboo dominated plots had higher abundance, floristic richness and recruitment of tree and shrub seedlings when compared with bamboo non‐dominated plots. Bamboo die‐off did not represent an opportunity to improve establishment and investment in the vertical growth (height) of seedlings in bamboo‐dominated plots. We postulate that the mode of rhizome extension seen in bamboos might be a consistent trait determining the spatial pattern of occupation and population structure and thereby playing a fundamental role in the pattern of native tree community establishment after bamboo die‐off. The formulation of a management approach is necessary in order to better understand the biological traits of bamboo species and their influence on the spatial pattern of occupation and population structure. Additionally, this influence may differently impact restoration and definition of management practices, including the need for direct intervention by manually controlling bamboo cover following die‐off to promote and maintain seedling establishment and diversity.

Acceleration or retardation by a magnetic field of the anodic processes of iron in molybdate-bearing chloride solutions.

The modulation by a horizontal magnetic field of the anodic processes of iron in molybdate-bearing chloride solutions is determined. The magnetic field can accelerate or retard the anodic reaction depending on the rate-controlling steps at specified electrode potentials. The anodic current density arising from uniform dissolution from open or semi-open pits is increased by the magnetic field. The current density originating from occluded pits can be decreased by the magnetic field, where autocatalysis has a dominant effect on the pitting rate. The effect of the magnetic field on the pitting corrosion is a combination of the influence on electrochemical reactions at the interfaces of the pits and the disturbance of the autocatalysis process inside the pit enclave through the magnetohydrodynamic (MHD) effect. Micro-MHD effects for specific locations and macro-MHD effects for pitting systems are recommended to illustrate the magnetic effect on localized corrosion phenomena at various combinations of potentials and solution compositions.

Parameter-based analysis of clinical efficacy of combined bed nucleus of the stria terminalis-nucleus accumbens deep brain stimulation for treatment-resistant depression.

Treatment-resistant depression (TRD) is a severely disabling psychiatric condition that responds poorly to conventional treatments. Deep brain stimulation (DBS) has been proposed for the treatment of patients with TRD in numerous studies. Several deep brain nuclei are considered as potential targets for TRD-DBS, but their clinical efficacy needs further validation. This study carried out dual-target combined stimulation of the bed nucleus of the stria terminalis (BNST) and nucleus accumbens (NAc) to investigate the effectiveness of the treatment for TRD patients. An 8-contact DBS electrode was used in the study with a surgical path that crossed the BNST and NAc targets. Stimulation parameters and the corresponding severity of symptoms evaluated by the 17-item Hamilton Depression Rating Scale (HAMD-17) and other scales were obtained at each follow-up. The accuracy of electrode positions, the effect of combined stimulation, and the corresponding stimulation parameters were evaluated. Sweet spot prediction models were used to assess the effective stimulation sites in the treatment. The study included 23 TRD patients undergoing DBS at a single center from March 2021 to May 2023. At the last follow-up (range 4-24 months), 14 patients had responded to the treatment (HAMD-17 score improved ≥ 50%), 7 of whom had achieved clinical remission (HAMD-17 score ≤ 7). Electrode position analysis suggested that the BNST may be more important for the improvement of depressive symptoms than the NAc. Overlapped volumes of volume of tissue activated (VTA) and BNST were significantly correlated with absolute (ρleft = -0.377, p < 0.001; ρright = -0.251, p < 0.001) and percent (ρleft = -0.249, p < 0.001; ρright = -0.098, p = 0.102) changes in HAMD-17 score. The sweet spot model of HAMD-17 improvement also suggested that the VTA overlap with the dorsal side of BNST was associated with the impact on depressive symptoms (t = -4.10, p < 0.05). Combined BNST-NAc stimulation of TRD can effectively improve depressive symptoms, in which the BNST seems to have a dominant therapeutic effect. The results of this study not only help to optimize the DBS programming parameters, but also offer an opportunity to further understand the differences between the two targets. In the future, larger prospective cohorts are needed to verify the results of combined BNST-NAc DBS.

Mechanism of inhibitory action of fruit cake extracts as a new environmentally inhibitors of carbon steel corrosion

In this study the firstly study reported on the use of plum, cherry, nectarine and apple pomace extract as corrosion inhibitors of steel in water solution. Potentiodynamic polarization study showed that extracts act as a mixed type inhibitors with dominant cathodic effect. Linear polarization resistance method (LRP) assesses the time-related effect of inhibitors during open circuit potential corrosion. The results show that the inhibitory efficiency of our extract increases with increasing time formation protective film to reach 99 % in a concentration of 500 ppm. LC - MS and FTIR spectroscopy techniques can be concluded that several water-soluble interaction products of chemical reaction in NaCl are identified namely flavanol–anthocyanin and flavanol-aldehyde adducts. Subsequently, the iron-mediated complexation and oxidation of the extract components (flvonoids) in the aqueous solution were explored using UV-spectrophotometric and HPLC methods. With the passage of time, iron-mediated oxidative degradation and coupling reactions occurred, resulting in the production of hydroxybenzoic acid derivatives. Consequently, the inhibition decreased after 24 h. The chemisorption type of interaction of the product formed in the inhibited solution forming the adsorption-polymerization layer with the steel surface is established. Based on the quantum-chemically calculated parameters of the electronic structure of flavanol–anthocyanin and flavanol-aldehyde adducts, it was established for the first time that the combination of reactive fragments in them, which are spatially located in different planes with a higher quantity of hydroxyl groups, increases their adsorption activity and, as a result, their inhibitory capacity.

Dual regulation effect and mechanism of human myeloid-derived suppressor cells on anticolorectal cancer cells activity of Vγ9Vδ2 T cells.

Myeloid-derived suppressor cells (MDSC) are a group of immature inhibitory cells of bone marrow origin. Human γδ T cells (mainly Vγ9Vδ2 T cells) have emerged as dominant candidates for cancer immunotherapy because of their unique recognition pattern and broad killing activity against tumor cells. Intestinal mucosal intraepithelial lymphocytes are almost exclusively γδ T cells, so it plays an important role in inhibiting the development of colorectal cancer. In this study, we investigated the effects and molecular mechanism of human MDSC on anticolorectal cancer cells activity of Vγ9Vδ2 T cells. Our results suggested that MDSC can reduce the NKG2D expression of Vγ9Vδ2 T cells through direct cell-cell contact, which is associated with membrane-type transforming growth factor-β. In contrast, MDSC can increase Vγ9Vδ2 T cells activation and production of IFN-γ, perforin, Granzyme B through direct cell-cell contact. This may be related to the upregulation of T-bet in Vγ9Vδ2 T cells by MDSC. However, MDSC had a dominant negative regulatory effect on the anticolorectal cancer cells activity of Vγ9Vδ2 T cells. Our study provides a theoretical basis for the immune regulatory function of human MDSC on γδ T cells. This will be conducive to the clinical development of a new antitumor therapy strategy.

Sb surface terminated MnSb devices in the niccolite phase

The magneto-electronic properties of ferromagnetic MnSb grown by molecular beam epitaxy can be dominated by the presence of a surface state in the minority spin bandgap when the surface is Sb-terminated. The material resistivity is 120 µΩ.cm at 295 K, and although this is determined by the majority spin population, the anisotropic magnetoresistance, dependent on minority spins, is ∼0.24% for the Sb-terminated devices with Mn-terminated devices showing ∼0.02%. At 295 K, the extraordinary Hall constant is 0.5 Ω/T for the Sb-terminated surface and 1.5 Ω/T for the Mn-terminated surface with the extraordinary Hall constant and anisotropic magnetoresistance behaving with an anomalous temperature dependence between 295 and 1.5 K. The dominant MnSb structural phase on the GaAs (001) orientation is naturally doped p-type with a carrier density ∼1 × 1022 cm−3 determined by the normal Hall effect after the extraordinary Hall effect has saturated at higher fields than ∼2 T. Spintronic device possibilities are discussed, particularly the spin-light emitting diode and magnetic nano-structures. A natural p-type doping in MnSb limits the devices to dominant hole carrier effects although there is compatibility with both III–V and Si–Ge materials for hybrid device possibilities.

Scour Impact on the Horizontal Bearing Capacity of Pier-Type Dolphin Structures

A study using numerical analysis techniques was conducted to examine the scour effect of pier-type dolphin structures installed in the domestic marine environment, and the effect of scour on horizontal bearing capacity was examined. In this study, we designed the berthing structures, taking into account the environmental and ground conditions of the target maritime area, and after calculating the predicted scour area, stability evaluation was performed by removing the ground elements of the area. The increase in scour depth was found to induce a direct decrease in horizontal bearing capacity due to soil loss in contact with the foundation, establishing a relationship that increases horizontal displacement. However, in the foundation designed to withstand the design load by reflecting the safety rate, the increase in horizontal displacement formed by possible scour is not large, which did not have a dominant effect on the horizontal bearing capacity of the foundation. In the future, research is required to analyze the impact of each factor and formalize evaluation and design techniques to evaluate the scour safety of marine foundations and pier-type structures installed in various ground conditions and structural formats.

Pathogenic Variant Frequencies in Hereditary Haemorrhagic Telangiectasia Support Clinical Evidence of Protection from Myocardial Infarction.

Hereditary haemorrhagic telangiectasia (HHT) is a vascular dysplasia inherited as an autosomal dominant trait, due to a single heterozygous loss-of-function variant, usually in ACVRL1 (encoding activin receptor-like kinase 1 [ALK1]), ENG (encoding endoglin [CD105]), or SMAD4. In a consecutive single-centre series of 37 positive clinical genetic tests performed in 2021-2023, a skewed distribution pattern was noted, with 30 of 32 variants reported only once, but ACVRL1 c.1231C>T (p.Arg411Trp) identified as the disease-causal gene in five different HHT families. In the same centre's non-overlapping 1992-2020 series where 110/134 (82.1%) HHT-causal variants were reported only once, ACVRL1 c.1231C>T (p.Arg411Trp) was identified in nine further families. In a 14-country, four-continent HHT Mutation Database where 181/250 (72.4%) HHT-causal variants were reported only once, ACVRL1 c.1231C>T (p.Arg411Trp) was reported by 12 different laboratories, the adjacent ACVRL1 c.1232G>A (p.Arg411Gln) by 14, and ACVRL1 c.1120C>T (p.Arg374Trp) by 18. Unlike the majority of HHT-causal ACVRL1 variants, these encode ALK1 protein that reaches the endothelial cell surface but fails to signal. Six variants of this type were present in the three series and were reported 6.8-25.5 (mean 8.9) times more frequently than the other ACVRL1 missense variants (all p-values < 0.0039). Noting lower rates of myocardial infarction reported in HHT, we explore potential mechanisms, including a selective paradigm relevant to ALK1's role in the initiating event of atherosclerosis, where a plausible dominant negative effect of these specific variants can be proposed. In conclusion, there is an ~9-fold excess of kinase-inactive, cell surface-expressed ACVRL1/ALK1 pathogenic missense variants in HHT. The findings support further examination of differential clinical and cellular phenotypes by HHT causal gene molecular subtypes.

Rotor crack breathing under unbalanced disturbance

Rotor cracks are a type of failure seriously affecting the safe operation of rotating machinery. It has been reported that cracks under the dominant effect of gravity produce a breathing effect and consequently result in an abnormal vibration of the rotor. However, in practice the rotor cannot avoid unbalance disturbances. As the rotational speed of the rotor continues to rise, unbalance replaces the dominant role of gravity and changes the breathing pattern of cracks. Therefore, this work aimed to study the crack breathing process during the acceleration phase of an unbalanced cracked rotor by coupling the strain energy release rate (SERR) technique with the neutral axis (NA) method. It was found that when the unbalance is dominant, the fracture surface remains fixed instead of being uniformly open and closed. That is, during the entire acceleration phase of the rotor, the crack undergoes a process from uniform breathing to breath-hold breathing. The change of breathing mode induces the whirl phenomenon in the cracked rotor, which gradually disappears with increasing unbalance. This whirl phenomenon can be combined with superharmonic resonance characteristics as an assessment tool for crack fault diagnosis. The above findings are helpful in diagnosing rotor cracking faults under unbalanced disturbances.

Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.

Macrophages (Mφ) can exist along a spectrum of phenotypes that include pro-inflammatory (M1) or anti-inflammatory (M2) immune cells. Mφ colony stimulating factor (M-CSF) and granulocyte Mφ colony stimulating factor (GM-CSF) are cytokines important in hematopoiesis, polarization and activation of Mφ. To gain a greater understanding of the relationship between GM-CSF and M-CSF, we investigated an in vitro model of differentiation to determine if GM-CSF and M-CSF can antagonize each other, in terms of Mφ phenotype and functions. We determined that Mφ cultured in mixed M-CSF: GM-CSF ratios exhibit M1-like GM-CSF-treated macrophage phenotype when the ratios of the two cytokines are 1:1 in culture. Moreover, GM-CSF is dominant over M-CSF in influencing Mφ production of proinflammatory cytokines such as IL-6, TNFα, and IL-12p40, and the anti-inflammatory cytokine IL-10. Our data established that GM-CSF is more dominant over M-CSF, triggering the Mφ to become pro-inflammatory cells. These findings provide insight into how GM-CSF can influence Mφ activation with implications in inflammatory diseases where the Mφ status can play a significant role in supporting the inflammatory conditions.

Alternating dominant effects of temperature and precipitation along elevational gradient on the alpine and subalpine vegetation activities in southwestern China

Elevation plays a pivotal role in modulating hydroclimatic dynamics, changing vegetation activity and shaping vegetation distribution patterns in alpine regions. Nevertheless, a conspicuous knowledge gap persists regarding the interaction between climate drivers on vegetation activity. In this study, we investigated the spatio-temporal patterns of the Normalized Difference Vegetation Index (NDVI), a proxy for vegetation activity, and examined its interactions with temperature (T) and precipitation (P) along elevational gradient (EG) in the Alpine and Sub-alpine Woodlands of Southwest China (ASWSC) during 2001–2018. We found that approximately 24% vegetation in ASWSC exhibited significant greening trend, as a result of regional warming and slight wetting during the study period. The greening and browning rates were both elevational asymmetric, with higher rates at lower elevations. We also illustrated an alternating domination of T - P on vegetation activity along EG. This suggested a roughly antagonistic effect between the two drivers within the whole vegetation elevation range except for a synergistic effect in the sub-alpine forests zone between 2300 - 4200 m. The antagonistic effect tended to be more pronounced in warm and dry years, while the synergistic effect was more evident in cold and wet years. Specifically for different vegetation types, we found an insignificant T - P interactive effect along EG in indigenous evergreen needleleaf forest (ENF) and evergreen broadleaf forest (EBF), in contrast to the significant synergistic effect in the regenerated deciduous broadleaf forest (DBF) and mixed forest (MF) and antagonistic effect in shrubland and grassland types. In summary, our study revealed alternating-dominant effects of temperature and precipitation on vegetation activity along EG. These findings will deepen our understanding of vegetation resistance and resilience to climate change and eventually contribute to establishing a scientific foundation for effective ecosystem management and conservation practices in alpine region.

Triple-collinear splittings with massive particles

We analyze in detail the most singular behaviour of processes involving triple-collinear splittings with massive particles in the quasi-collinear limit, and present compact expressions for the splitting amplitudes and the corresponding splitting kernels at the squared-amplitude level. Our expressions fully agree with well-known triple-collinear splittings in the massless limit, which are used as a guide to achieve the final expressions. These results are important to quantify dominant mass effects in many observables, and constitute an essential ingredient of current high-precision computational frameworks for collider phenomenology.

Revealing the fretting corrosion mechanisms of laser shock peened cold spray 316 L stainless steel

The influence of laser shock peening (LSP) on the fretting corrosion (FC) resistance of cold spray (CS) 316 L stainless steel (SS) was investigated. Results reveal that LSP allowed for less surface fracturing to occur during FC. The influence of FC also promoted the formation of Ni within the wear scar. Due to the accumulation of debris, galvanic corrosion occurred, increasing the wear-corrosion synergism. Despite this, the surface-strengthening effect of LSP had a dominant effect on FC degradation resistance, ultimately reducing material loss. Based on these findings, LSP is a viable treatment to control the FC resistance of CS 316 L SS.

Effects of alternating current on microbiologically synergistic corrosion of pipeline steel X80 applied by elastic stress

Microorganisms play an important role in multi-factor synergistic corrosion. The synergistic effects of which are greatly stronger than elastic stress and alternative current. Changes of alternative current directly dominate the effect of microbial synergy. With increasing AC current density, corrosion rate of pipeline steel X80 increased first and then decreased, reaching a peak at 100 A m−2. Number of SRB cells vaired as a function of AC current density. Lower current density promoted SRB growth while high current density inhibited SRB growth. When sessile cells are more than 105 cell cm−2, the dominant role of microorganisms is strong, and corrosion rate increases with current density. The maximum value is reached at 100 A m−2. However, when the cells are less than 103 cell cm−2, the dominant effect is greatly reduced, leading to a reduction in the synergistic effect of the multi-factor, and finally reduced corrosion rate to 200 A m−2.

Solvatochromic shifts and solvent effects on the electronic and transport behaviour of 1-Chloro Adamantane

Solvent influence on the photophysical and electronic properties of 1-Chloro Adamantane (CAD) are investigated using experimental and computational methods. Measured UV–vis absorption of CAD in various solvents exhibits substantial solvatochromatic shifts with respect to the solvent polarity. As a result of this, optical absorption of CAD undergoes the bathochromic shifts in the nonpolar solvents and hypsochromic shifts in the polar solvents with respect to polarity. Theoretical computations of EOM-CCSD and CIS quantum chemical methods calculated by means of SMD solvation model demonstrate the solvent influence on the electronic structure of CAD which are in good agreement with the experimental results. Computed results show prominent solvation effect on Lewis and non-Lewis occupancies. Large excited state dipole moment of the CAD in various solvation suggests excited states are more polarized than the ground state. In addition to this, molecular polarizabilities and energies of HOMO and LUMO show dominant solvent effects on the chemical reactivity of the CAD upon solvation. This solvent specific behaviour of CAD finds applications in optical filters with its significant hydrophobic nature.

Investigating the Spatial, Proximity, and Multiscale Effects of Influencing Factors in the Snowmelt Process in the Manas River Basin Using a Novel Zonal Spatial Panel Model

It is essential to investigate the influences of environmental elements on snow cover to understand the mechanism of the snowmelt process. These elements, as influencing factors, have spatial heterogeneity, which results in significant differences and uncertainties in the extent and range of their effects at different scales. However, little research has been conducted on the spatial interaction and mechanisms of these factors at multiple scales. This study selected the Manas River basin in the Tianshan Mountains as the study area. The study period is 2015–2020. The snow cover status index is calculated based on available Landsat8-OLS/TIRS data; influencing factors are collected from multiple datasets. Their relationships are explored using a novel zonal spatial panel model, fully considering the spatial, proximity, and scale effects. The findings are as follows: (1) There is a robust spatial interaction and proximity effect between snowmelt and various factors, and such effects display distinct spatial heterogeneity. The elevation (ELE), slope (SLP), land surface temperature (LST), and normalized digital vegetation index (NDVI) showed significant overall dominant effects on the snow melting process. The influencing factors with apparent proximity effects are LST, ELE, SLP, NDVI, and air temperature (TEMP), and their influence ranges are different. (2) The relative importance and significance rank of dominant influencing factors vary under different partition schemes and scales. As the scale decreases, the significance of terrain- and vegetation-related factors increases, whereas the significance of temperature- and elevation-related factors decreases, and the number of dominant factors also decreases. (3) The influencing factors represent distinct characteristics among each zone at the optimally partitioned scale we defined. The overall influencing pattern demonstrates a characteristic of being globally dictated by elevation and temperature, with local terrain factors, vegetation, and wind speed modifying this pattern. Our study provides practical data support and a theoretical basis for deepening our understanding of the influence mechanism of the snow melting process.

Axial compressor blades tip leakage flow control using natural aspiration

Blades tip leakage flow structure in axial compressors has dominant effects on flow stability and losses. Accordingly, in the present study, three different ideas are introduced for alleviation of undesirable effects of the blades tip leakage flow. These ideas utilize circumferential tape, S-shape nozzle and natural aspiration slot, all imposed upstream the rotor blades row. The method of investigation is based on numerical simulation of the governing flow field. Results, in terms of the flow field structure and performance curves are compared with those of the untreated case. Final results, showed that the natural aspiration idea works better than the other ones. In comparison to the plane case, it is accompanied by augmentation of 3.5% in the total pressure ratio and 3% in the surge margin. It was also found that the mass flow rate passing through the blades row tip gap has increased by 2.33 g/s in the natural aspiration case.

Effect of RIBS/FINS and Aspect Ratio on Flow Boiling Characteristics in Conventional Channels

Abstract In this work, experiments are conducted with conventional rectangular channels of two different aspect ratios (AR = w/d) for the horizontal boiling flow conditions at atmospheric pressure. Distilled water was used as the working substance. The heat transfer coefficients (HTC) were measured for mass fluxes and heat fluxes ranging from 85.94 kg/m2-s to 343.77 kg/m2-s and 10 kW/m2 to 100 kW/m2, respectively, and at inlet subcooled temperatures of 303 K, 313 K, and 323 K. Visualization of the boiling phenomenon was done using a high-speed camera for the two channels under similar conditions. The results show that the AR has a dominant effect on the HTC. At low heat flux values, higher HTC was noticed for the channel of higher AR (AR = 1.25) whereas, at high heat flux conditions, the HTC is higher for the channel of lower AR (AR = 0.2). With an increase in inlet subcooled temperature, the HTC decreased for both channels due to increased thermal boundary layer thickness and reduced bubble formation. Further, the channel of AR = 1.25 with ribs/fins performed better than the smooth channel due to the high bubble nucleation rate.

Neurofilaments in health and Charcot-Marie-Tooth disease.

Neurofilaments (NFs) are the most abundant component of mature neurons, that interconnect with actin and microtubules to form the cytoskeleton. Specifically expressed in the nervous system, NFs present the particularity within the Intermediate Filament family of being formed by four subunits, the neurofilament light (NF-L), medium (NF-M), heavy (NF-H) proteins and α-internexin or peripherin. Here, we review the current knowledge on NF proteins and neurofilaments, from their domain structures and their model of assembly to the dynamics of their transport and degradation along the axon. The formation of the filament and its behaviour are regulated by various determinants, including post-transcriptional (miRNA and RBP proteins) and post-translational (phosphorylation and ubiquitination) modifiers. Altogether, the complex set of modifications enable the neuron to establish a stable but elastic NF array constituting the structural scaffold of the axon, while permitting the local expression of NF proteins and providing the dynamics necessary to fulfil local demands and respond to stimuli and injury. Thus, in addition to their roles in mechano-resistance, radial axonal outgrowth and nerve conduction, NFs control microtubule dynamics, organelle distribution and neurotransmission at the synapse. We discuss how the studies of neurodegenerative diseases with NF aggregation shed light on the biology of NFs. In particular, the NEFL and NEFH genes are mutated in Charcot-Marie-Tooth (CMT) disease, the most common inherited neurological disorder of the peripheral nervous system. The clinical features of the CMT forms (axonal CMT2E, CMT2CC; demyelinating CMT1F; intermediate I-CMT) with symptoms affecting the central nervous system (CNS) will allow us to further investigate the physiological roles of NFs in the brain. Thus, NF-CMT mouse models exhibit various degrees of sensory-motor deficits associated with CNS symptoms. Cellular systems brought findings regarding the dominant effect of NF-L mutants on NF aggregation and transport, although these have been recently challenged. Neurofilament detection without NF-L in recessive CMT is puzzling, calling for a re-examination of the current model in which NF-L is indispensable for NF assembly. Overall, we discuss how the fundamental and translational fields are feeding each-other to increase but also challenge our knowledge of NF biology, and to develop therapeutic avenues for CMT and neurodegenerative diseases with NF aggregation.