ABSTRACT This study explores the impact of life course socioeconomic status (SES) and childhood trauma on depressive symptoms in Chinese middle-aged and older adults, while also examining the role of chronic diseases and implications for social work practice. Using data from 9,942 participants, structural equation was established to investigate these relationships. Results reveals that low childhood SES positively affects depressive symptoms through low SES in mid-to-late life (std. β = 0.168, p < .001), and domestic child abuse negatively impacts depressive symptoms through low SES in mid-to-late life (std. β=-0.020, p < .001). Additionally, experiencing peer bullying is directly associated with depressive symptoms (std. β = 0.145, p < .001). Exposure to domestic violence is directly related to depressive symptoms (std. β = 0.078, p < .001) and indirectly leads to more severe depressive symptoms through chronic disease (std. β = 0.023, p < .001). Social workers in healthcare settings can utilize these findings to better understand risk factors for depression and provide trauma-informed care and economic assistance across the life course. Additional training for social workers on the lasting impacts of childhood adversity is warranted. By intervening at both individual and policy levels, social work practitioners can help break cycles of poverty and poor health stemming from childhood.