Compound feed are subject to requirements for their composition, since they use several types of grains that contain anti-nutritive substances that reduce the digestibility and use of nutrients. One of the tasks of domestic poultry farming is to reduce losses by increasing the digestibility and accessibility of feed. Among the most effective ways to solve this problem is to add enzymes to the feed of poultry. The inclusion of enzyme drugs in the composition of compound feed contributes to the inactivation of anti-nutritive substances, which contributes to an increase in the coeffi cient of digestibility of nutrients. The purpose of the work was to establish the feasibility and eff ectiveness of the enrichment of compound feed used in the production technology of chicken eggs with mixtures of enzyme drugs of domestic production of Amylosubtilin G3x, Cellolux-F and Protosubtilin G3x. Three groups of laying hens with 57 heads in each have been formed: a control group and two experimental groups. The duration of the experiment was 420 days. Laying hens of the control group have been received farm compound feed depending on their age. Laying hens of the 1st experimental group have been received compound feed of the control group enriched with the enzymes Amylosubtilin G3x and Cellolux-F depending on the age. In the compound feed of laying hens of the 2nd experimental group enzyme drugs were additionally introduced depending on the age Amilosubtilin G3x and Protosubtilin G3x. Higher egg production rates have been observed in the 1st experimental group – 357,81 eggs, which was 6,48 % higher than in the control group and 1,84 % higher than in the 2nd experimental group. The weight of eggs of laying hens of the 1st experimental group was 1,85 g or 2,97 % more, and the 2nd experimental group was 0,7 g or 1,12 % more than in the control group. The diff erence between the egg weight in laying hens of the 1st and 2nd experimental groups was 1,85 % or 1,15 g. The lowest feed consumption of 1,37 kg for the production of 10 eggs was in the laying hens of the 1st experimental group, which was less than the indicator of the control group by 10,94 and by 4,2 % than in the 2nd experimental group.