Domains Of Health-related Quality Research Articles

Parent-child agreement on health-related quality of life: the role of perceived consequences of the child’s chronic illness

Objective We aimed to assess the parent-child agreement on various domains of health-related quality of life (HRQoL) in a Hungarian pediatric sample. We examined the associations of demographic, illness-specific factors and the perceived consequences of the illness with the parent-child disagreement. Design A cross-sectional study was carried out with child-parent pairs in a heterogeneous pediatric sample (n = 259). Outcome Measures Child and parent versions of Kidscreen-52 and the consequences scale of the Revised Illness Perception Questionnaire (IPQ-R) were applied. We used intraclass correlation coefficients to measure agreement. We computed directional discrepancies as dyadic indexes and applied them in multinomial regression analysis to identify factors influencing agreement. Results Agreement between children and parents on the KIDSCREEN-52 instrument was moderate to good (ICC = 0.41 to 0.66). Significant (p < 0.005) parent-child disagreement was observed on 6 out of 10 dimensions of HRQoL: Parents rated their children’s well-being lower on Physical Well-being, Psychological Well-being, Parent Relations and Home Life, Social Support and Peers, and Financial Resources scales and rated higher on Moods and Emotions compared to child-reported HRQoL. Both parent’s and child’s higher perceived illness consequences made disagreement significantly more likely on various domains. Conclusions Direction of disagreement may draw attention to potentially vulnerable domains of the child’s well-being, like moods and emotions and self-perception.

Health-Related Quality of Life in people with Multiple Sclerosis: How does this Population Compare to Population-based Norms in Different Health Domains?

PurposeThe purposes of this investigation were to (1) identify the domains of health-related quality of life most impacted in people with RRMS, (2) compare the health-related QOL in people with RRMS to general population norms, and (3) to describe subgroups within the RRMS population that have similar health and wellness needs.MethodsThis was a cross-sectional QOL investigation of adults with RRMS. The SF-36v2 survey and demographic information were collected electronically via Qualtrics. Participants (n = 120) were recruited through social media and the National Multiple Sclerosis Society of the United States. One-sample Z-tests were completed for all subscales, and component mean scores to determine if a difference between the sample and population norms existed.ResultsAll values of z were statistically significant, p < .01, for all subscale and composite scores. Social function, physical function, and the mental health component scores had the lowest subscale means. A first stage depression screen revealed that 49% of the surveyed population were at risk for depression, compared to 18% in the general population. Further dividing the sample into years since MS diagnosis, the recently diagnosed group had 61% at risk for depression.ConclusionsChallenges related to the mental health of individuals with RRMS are influencing overall health-related QOL. Early on in the disease course (0–3 years), mental health affected QOL more than physical health. More attention must be given to the nonphysical domains of health to advance the QOL for people with RRMS.

Influence of Sociodemographic and Clinical Characteristics on Sexual Function Domains of Health Related Quality of Life in Multiple Sclerosis Patients.

Background:Multiple sclerosis is a progressive inflammatory disease of the the central nervous system. Problems with sexual functions are the common features of multiple sclerosis and important factor that contribute to the quality of life among affected persons.Objective:The aim of the study was to evaluate the influence of sociodemographic and clinical characteristics on sexual functions domains of health related quality of life (HRQOL) in multiple sclerosis patients.Methods:This study included 100 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were an Expanded Disability Status Scale score between 1.0 and 6.5, age between 18 and 65 years, stable disease on enrollment. HRQOL was evaluated by the Multiple Sclerosis Quality of Life-54 questionnaire. Mann-Whitney and Kruskal-Wallis test were used for comparisons between sociodemographic and clinical characteristics and HRQOL scores.Results:Out of 60% of patients reported to have sexual dysfunction, and 55 % were female patients. Younger patients had statistical significant higher median value of sexual function score (91.68 vs. 58,28, p=0.001) and satisfaction with sexual life scores (62.5 vs 37.5 , p =0.019) comparing to older patients. Employed patients also showed statistical significant higher median value of sexual function score (82 vs. 66.7, p=0.003) comparing to unemployed patients and also statisticaly significant higher median scores considering satisfaction with sexual life among employed patients (p=0,001). There were no differences in sexual functions scores considering gender, marital status and education. Patients with higher level of disabilty, progressive type of disease, more relapses and longer diseas duration had statistical significant lower median value of sexual function score and also satifaction with sexual life scores, except for disease durationConclusion:Aging, dysability and progression are major factors that contribute to lower sexual function scores and satisfaction with sexual life among multiple sclerosis patients. Althoug women reported sexual problems more often then men, impact of these problems on quality of life are similar in men and women with MS.

HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN OLDER ADULT SUBJECTS WITH KNEE OSTEOARTHRITIS PAIN

Aim of the study: The study aims to find the health-related quality of life (HRQoL) in older adult subjects with knee osteoarthritis pain. Material and methods: A cross-sectional, telephonic study was done on knee osteoarthritis subjects above 50 years of age. Socio-demographic scales and details,(ShalliBavoria, et al., 2020) i.e., WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), SF-12 (Short Form survey), PHQ-9 (Patient Health Questionnaire) et al were applied( Soo-Hyun Park and Byeong-Hun Kang., 2020). Information was retrospectively compiled and a semi-structured proforma was selected to gather the clinical variables. Results: Results were identified by domains of Health related quality of life.Results showed that there is significant difference in general health related quality of life based on the KL grading of KOA.(P=0.02,P=0.04)Study concluded that general HRQoL worsens with higher grading of KOA.The results showed that there was a substantial discrepancy witnessed between males and females where females encountered more pain.As stiffness increases HRQoL decreases. More severity of pain was observed in depressed people.(Roger B. Fillingim, et al., 2020) Conclusion: Daily challenges and actions, of which some may be unusual to sufferers in a pastoral setting in India, underlie sedentary and effective strategies to Osteoarthritis and its control. The study concluded that a significant difference in pain and general quality of life-based on the KL grading of KOA (P=0.02, P=0.04) was observed.(Hye-Young Shim, etal, 2018) It was also found that there is a considerable difference in pain based on the duration of ]knee osteoarthritis (P=0.05).( Aliasghar A. Kiadalir, et al., 2017).

Neuropathic pain symptoms in inflammatory hand osteoarthritis (OA) lower quality of life and may require another approach than anti-inflammatory treatment

Purpose: Pain is a common, disabling and difficult to manage symptom in hand osteoarthritis (OA). Both nociceptive and neuropathic pain mechanisms may play a role in hand OA. These two types of pain may require different treatment. Therefore, this study aimed to investigate whether neuropathic pain symptoms are present in patients with inflammatory hand OA, to investigate characteristics of those patients and the impact of neuropathic pain symptoms on the physical domain of health related quality of life (HR-QoL), and whether neuropathic pain symptoms are influenced by anti-inflammatory treatment.

The factor structure of major depressive symptoms in a sample of Chinese earthquake survivors

BackgroundExperiencing natural disasters is associated with common mental disorders including major depressive disorder (MDD). However, the latent structure of MDD is widely debated, and few studies tested the MDD factor structure in Chinese natural disaster survivors. Therefore, the aim of the current study was to evaluate the factorial validity of the Patient Health Questionnaire-9 (PHQ-9) for DSM-5 major depressive disorder (MDD) symptoms in Chinese earthquake survivors.MethodParticipants were 1058 Chinese earthquake survivors. Self-reported measures included the PHQ-9 and the Short-Form Health Survey (SF-36). Confirmatory factor analysis (CFA) and structural equation modelling (SEM) was used to examine the latent structure of MDD and the associations between latent factors of MDD and different domains of health-related quality of life (HRQoL), respectively.ResultsIn the current sample, the model consisted of somatic and cognitive/affective (non-somatic) factors demonstrated significantly better fit than the other competing MDD models (χ2 = 173.89, df = 26, CFI = 0.986, TLI = 0.981, RMSEA = 0.073, BIC = 18,091.13). Further SEM analyses indicated that the non-somatic factor was significantly related to both physical (β = − 0.362, p < .01) and psychosocial HRQoL (β = − 0.773, p < .01), while the somatic factor was a uniquely predictor of physical HRQoL (β = − 0.336, p < .01). Furthermore, we found the somatic factor partially mediated the relationship between the cognitive/affective factor and physical HRQoL (all ps < .05).ConclusionsThe MDD symptoms was best captured by a two-factor model comprised of somatic and cognitive/affective factors in Chinese natural disaster survivors. The two MDD factors were differentially associated with physical and psychosocial HRQoL, and the cognitive/affective factor associated physical HRQoL partially through the somatic factor. The current findings increase our understanding of latent structure of MDD symptoms, and carry implications for assessment and intervention of post-disaster mental health problems.

Assessment of Health Related Quality of Life among Chronic Kidney Disease Patients: Challenges for Nephrologists in Pakistan

Introduction: During the past few decades, health related quality of life has been considered as an important predictor for positive health outcomes. Health-related quality of life assessment helps in determining the impact of disease on the everyday life of patients. Chronic kidney disease severely affects health related quality of life of patient.&#x0D; Objective: The objective of this study was to assess health related quality of life among patients with chronic kidney diseases in Pakistan.&#x0D; Methodology: A descriptive cross-sectional study design was used. Study respondents included CKD pre-dialysis and dialysis patients with or without comorbidities visiting tertiary care facilities located in twin cities of Pakistan. Sample size was calculated to be 386 pharmacists to achieve 95% confidence level with 5% margin of error. Convenient sampling technique was used to select respondents. A pre- validated questionnaire Kidney Disease Quality of Life questionnaire (KDQoL-36) was used. Data was coded and analyzed using SPSS 21 after collection. Mann-Whitney and Kruskal-Wallis (p ≥ 0.05) tests were according to different demographic variables.&#x0D; Results: The results of the current study showed lowest scores for HRQoL in domain of physical health composite (30.77±11.16) followed by domain of symptoms and problems associated with CKD whereas daily life had the highest scores. The results highlighted that females had better HRQoL in all domains mental health (46.30, ± 8.73), burden of kidney disease (69.47, ± 32.35), symptoms (29.79, ± 31.22) and effect of disease on daily activities (40.96, ± 32.11) while lowest score for physical health (30.90, ± 10.34). Married respondents had better HRQoL among all domains than unmarried patients except for physical health (32.26, ± 10.7). A significant difference (p ≥ 0.05) was observed among different domains of HRQoL of CKD patients with respect to different genders, marital status, age groups and qualification levels. Males had relatively better physical health scores but their daily activities were also affected more by their disease. Married respondents had relatively better HRQoL among all domains than unmarried patients except for physical health. No significant difference (p ≥ 0.05) was observed for different stages of disease.&#x0D; Conclusion: The present study concluded that patients with CKD had poor HRQoL regardless of novel treatments availability. A negative impact was observed across all domains of health related quality of life among chronic kidney disease patients. Necessary programs focusing on health education for patients with low literacy levels should be initiated to increase health awareness and improve mental health among CKD patients.

HEALTH RELATED QUALITY OF LIFE AND IT'S ASSOCIATION WITH MEDICATION ADHERENCE FOR PATIENTS WITH PULMONARY TUBERCULOSIS

Background:Tuberculosis (TB) has been ranked to be one of the top ten causes of global mortality worldwide. The concept of health-related quality of life (HRQOL) might be of a multi-dimensional nature, it includes psychological, physical and social aspects. The effectiveness of medical interventions is influenced by adherence. Aim: This study aims to assess the correlation between health related quality of life (HRQOL) and medication adherence for Patients with pulmonary tuberculosis. Subjects and Method: A design based on descriptive correlational research was utilized. Convenient sample of pulmonary tuberculosis patients (56) at Almasaha Albahary at Port Said City and Chest Hospital at Damietta City. Three structured interviews were utilized to gather the required data. Data collection tools: Tool I: structured interviewing questionnaire, Tool II: Health Related Quality of life for patients with chronic illness, Tool III: Morisky Medication Adherence Scale (MMAS-8). Results: this study showed that 67.9% of the subjects were high psychological domain of health related quality of life and moreover, 75% of them were highly adhered to medications. Conclusion: it can conclude that three fifth of the studied patients had high QOL and three quarters of the patients had high adherence to medication. This study showed that there was statistically positive correlation between HRQOL domains (Physical, psychological, social) of HRQOL and drug adherence. Recommendation: the study recommended the event of program for patients with TB to enhance the patients’ knowledge, care management and modify their wrong beliefs associated with TB.

Health Related Quality of Life Post Labour Induction with Misoprostol Versus Dinoprostone At Muhimbili National Hospital in Dar Es Salaam, Tanzania: A cross Sectional Study.

Background:Labour induction using Misoprostol or Dinoprostone results to similar maternal and foetal clinical outcomes. However, the clinical outcome measures have rarely been combined with effects of interventions on patients' health related quality of life. This study aimed to assess postpartum health related quality of life of parturient after labour induction with vaginal administration of misoprostol versus dinoprostone.Methods:This was a comparative cross sectional study in which pregnant women who underwent labour induction with misoprostol and dinoprostone during the study period were included. Data were collected within 24 hours post-delivery using the 36 item short form health survey questionnaire which consists of 24 attributes distributed in five domains including bodily pains and physical performance three attributes each, mental health seven attributes, general health two attributes, social functioning six attributes and three attributes for labour induction satisfaction. We first estimated scores of all attributes in each domain using Likert scales and then the domain scores were converted into a 0 to 100 scales to express in percentage of total scores. Quality of life was compared in the two study groups using the independent samples T Test. Multivariate regression analysis was performed to control for marital status, gravidity, parity, baseline cervical status, time interval from induction to delivery and mode of delivery.Results:Women who received misoprostol reported better health related quality of life compared to those who received dinoprostone (mean score 92.89 vs. 87.25;P<.00). Misoprostol group had significantly higher scores in all domains of health related quality of life; reduced bodily pain (93.76 vs. 84.19;P<.00), physical performance (83.64 vs. 73.58;P<.00), mental health (96.40 vs. 93.55; P<.00), general health (93.78 vs. 90.23;P=.01), social functioning (94.81 vs. 91.25;P<.00) and satisfaction perceptions (94.96 vs. 90.71;P<.00).Conclusion:Health related quality of life information is of particular value in routine care of natal and postnatal mothers. Current and updated guidelines should address the impacts of labour induction interventions on maternal health related quality of life, and encourage the use of quality of life information in provision of holistic natal and postnatal care services. Clinical trials are recommended to determine the effectiveness of labour induction with either of the two methods and address the historical adverse outcomes associated to the use of misoprostol.

PNS202 COMPARING PROMIS-29 AND EQ-5D-5L: SYNTHESISING EVIDENCE FROM LITERATURE AND COMPARING THE VALUE SETS

PROMIS-29 and EQ-5D-5L are widely-used preference-weighted patient-reported outcomes in the health utility field, each with large and growing impact on Health Technology Assessment worldwide. The instruments have different features in terms of domains of health related quality of life and preference elicitation, and so it is important to assess the impact of choosing either instrument for the decision-making process. This study presents a comparison of the instruments, synthesising existing evidence, and comparing the characteristics of the value sets available for EQ-5D-5L and PROPr (the US utilities for the PROMIS-29). First, a literature review was conducted in PubMed and Web of Science to identify research studies investigating the relationship between PROMIS-29 and EQ-5D-5L. Then, we investigated the differences in terms of the descriptive system for PROMIS-29 and EQ-5D-5L and how such differences are reflected in utility scores by assessing the characteristics of the value sets. We used the PROPr utilities for PROMIS-29 and three value sets for EQ-5D-5L (Australian, UK and US). A total of 59 unique abstracts were identified from the literature search. However, only one study examined the relationship between PROMIS-29 and EQ-5D-5L (using EQ-5D-3L crosswalk value set). The comparison between the value sets shows that differences exist in overall range, the shape of the distribution of possible values, the proportions of health states valued better and worse than dead, and values between adjacent states in the respective descriptive systems. There is a dearth of literature examining the relationship between PROMIS-29 and EQ-5D-5L, and important differences exist between PROMIS-29 and EQ-5D-5L value sets. Future work is needed to assess the differences between the two instruments using data from both the general population and patient populations.

Developing item banks to measure three important domains of health-related quality of life (HRQOL) in Singapore

ObjectivesTo develop separate item banks for three health domains of health-related quality of life (HRQOL) ranked as important by Singaporeans – physical functioning, social relationships, and positive mindset.MethodsWe adapted the Patient Reported Outcomes Measurement Information System Qualitative Item Review protocol, with input and endorsement from laymen and experts from various relevant fields. Items were generated from 3 sources: 1) thematic analysis of focus groups and in-depth interviews for framework (n = 134 participants) and item(n = 52 participants) development, 2) instruments identified from a literature search (PubMed) of studies that developed or validated a HRQOL instrument among adults in Singapore, 3) a priori identified instruments of particular relevance. Items from these three sources were “binned” and “winnowed” by two independent reviewers, blinded to the source of the items, who harmonized their selections to generate a list of candidate items (each item representing a subdomain). Panels with lay and expert representation, convened separately for each domain, reviewed the face and content validity of these candidate items and provided inputs for item revision. The revised items were further refined in cognitive interviews.ResultsItems from our qualitative studies (51 physical functioning, 44 social relationships, and 38 positive mindset), the literature review (36 instruments from 161 citations), and three a priori identified instruments, underwent binning, winnowing, expert panel review, and cognitive interview. This resulted in 160 candidate items (61 physical functioning, 51 social relationships, and 48 positive mindset).ConclusionsWe developed item banks for three important health domains in Singapore using inputs from potential end-users and the published literature. The next steps are to calibrate the item banks, develop computerized adaptive tests (CATs) using the calibrated items, and evaluate the validity of test scores when these item banks are administered adaptively.

Health related quality of life and its correlates among people with depression attending outpatient department in Ethiopia: a cross sectional study

BackgroundDepression is a common mental disorder negatively affects the cognitive, emotion, behavior, functionality and quality of life of people. Poor quality of life results in high rates of relapse, inability to perform occupational and social activities, impaired future outlook, and increases overall health care related costs. However, there is no available evidence regarding the health related quality of people with depression in Ethiopia. Therefore, evaluating the quality of life of people with depression is crucial.ObjectiveThe aim of this study was to assess the health related quality of life and its correlates among people with depression at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.MethodsAn institutional based cross-sectional study was conducted from May 1st to 30th, 2018. A randomly selected 394 clients with depression were participated in this study. Health related quality of life was measured using world health organization quality of life brief. The collected data were coded and entered to SPSS version 20 for analysis. Step wise multiple linear regression analysis was used to identify the correlates of quality of life and the strength of the correlation was measured by β coefficient with 95% confidence interval.ResultsThe mean (±SD) scores of quality of life of people with depression were 41.3 ± 7.5, 42.8 ± 8.2, 38.9 ± 8.9 and 41.8 ± 6.5 for physical, psychological, social and environmental domains, respectively. The Multiple regression analysis showed that age of respondents, age of onset of depression, perceived stigma, living arrangement, social support level and duration of illness were statistically significant predictors of health related quality of life of people with depression in all or at least one domain of quality of life.ConclusionsThis study revealed that nearly half of study participants scored below the mean score in each domain of health related quality of life. This demonstrates a need for improving the quality of life of people with depression through the integration of a positive mental health approach and bio-psychosocial view together with the pharmacological treatments of depression. Moreover, strengthening social support, early identification and treatment of depression and prevention of stigma are also highly recommended to improve the quality of life of people with depression.

Development and calibration of a novel social relationship item bank to measure health-related quality of life (HRQoL) in Singapore

BackgroundSocial relationships (SR) is an important domain of health-related quality of life. We developed and calibrated a novel item bank to measure SR in Singapore, a multi-ethnic city in Southeast Asia.MethodsWe developed an initial candidate pool of 51 items from focus groups, individual in-depth interviews and existing instruments that had been developed and/or validated for use in Singapore. We administered all items in English to a multi-stage sample of subjects, stratified for age and gender, with and without medical conditions, recruited from community and hospital settings. We calibrated their responses using Samejima’s Graded Response Model (SGRM). We evaluated a final 30-item bank with respect to Item Response Theory (IRT) model assumptions, model fit, differential item functioning (DIF), and concurrent and known-groups validity.ResultsAmong 503 participants (47.7% male, 41.4% above 50 years old, 34.0% Chinese, 33.6% Malay and 32.4% Indian), bi-factor model analyses supported essential unidimensionality: explained common variance of the general factor was 0.805 and omega hierarchical was 0.98. Local independence was deemed acceptable: the average absolute residual correlations were < 0.06 and 1.8% of the total item-pair residuals were flagged for local dependence. The overall SGRM model fit was adequate (p = 0.146). Five items exhibited DIF with respect to age, ethnicity and education, but were retained without modification of scores because they measured important aspects of SR. The SR scores correlated in the hypothesized direction with a self-reported measure of global health (Spearman’s rho = − 0.28, p < 0.001).ConclusionThe 30-item SR item bank has shown acceptable psychometric properties. Future studies to evaluate the validity of SR scores when items are administered adaptively are needed.

Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients

BackgroundProspective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining changes in these parameters in the first post-operative year in both groups.MethodsTwenty-two kidney transplant recipients and 22 healthy kidney donors were included in this prospective longitudinal study with a follow-up until twelve months. PF was assessed by handgrip strength (HGS), and by the physical domains of health-related quality of life (HRQOL) using the Short Form-36 questionnaire [PF (SF-36 PF) and physical component summary (PCS) score]. BC was measured by the Body Composition Monitor©, and PA was measured by the SenseWear™ pro3.ResultsAt baseline, recipients had significantly lower HGS (after adjustment for sex and body weight), SF-36 PF, PCS, and PA, as compared with their donors. In recipients HGS significantly increased in the first year after transplantation, but PA did not change in the first six months after transplantation. Furthermore, no significant increase in lean tissue mass was observed. For healthy donors no significant changes in these parameters were observed, with exception of SF-36 PF, which declined in the first three months after donation, but equaled baseline values after twelve months.ConclusionRecipients showed impressive improvements in PF and the physical domains of HRQOL in the first year after transplantation, reaching levels of healthy kidney donors already three to six months after transplantation. On the contrary, living kidney donation did not show any deterioration of the investigated parameters, supporting little impact for well-screened donors, while there is high benefit for transplant recipients.

Progressive Muscle Relaxation and Symptoms of Women with Breast Cancer Undergoing Adjuvan Chemotherapy

This study was performed to examine effect of PMR on health related quality of life domains in breast cancer women received adjuvan chemotherapy, with one group pre-test post-test design. It was conducted among 15 breast cancer women received adjuvan chemotherapy who met the ctriteria for inclusion in the study with consecutive sampling in surgical outpatient of Wahidin Sudiro Husodo Hospital. The participants were instructed practice PMR for 12 days twice a day. First day and thirteenth day EORTC QLQ-30 version 3.0 questionnaires used to collected data. Average range of all obtained EORTC QLQ-30 symptom scales improved significantly: fatigue, nausea-vomiting, pain, insomnia, lack of appettite; except for dyspnea. Dyspnea are initially mild to no complaints at all, whereas cognitive function requires a longer period to be optimal return. PMR improved domains of health related quality of life among breast cancer women received adjuvan chemotherapy.

Predictors of mobility domain of health-related quality of life after rehabilitation in Parkinson\u2019s disease: a pilot study

BackgroundParkinson’s disease impacts health-related quality of life (HRQoL), however no studies inquired on predictors of HRQoL changes after rehabilitation. This study assessed the relationship between mobility domain of HRQoL measured by Parkinson’s Disease Questionnaires-39 (PDQ-39) and clinical-demographic characteristics and developed a model predicting changes after rehabilitation.MethodsSubjects with Parkinson’s disease underwent rehabilitation treatment and completed the following predictors: 10-m walking test (10MWT), Timed Up and Go (TUG), Berg Balance scale (BBS), Activities-specific Balance Confidence scales (ABC), Freezing of Gait (FOGQ) and PDQ-39. Two general linear models were calculated to predict the relationship between HRQoL at baseline and to predict HRQoL changes after rehabilitation.ResultsForty-two subjects (age 74.9 ± 7.3 years, Hoehn&Yahr 2.8 ± 0.6) completed the baseline evaluation. The first model (multiple R2 = 0.59, F = 5.86, P < 0.001) showed that ABC (B = − 0.51, CI = − 0.86 to 0.15, R2 = 0.41, P = 0.005) and FOGQ (B = 2.38, CI = 1.03 to 3.73, R2 = 0.07, P = 0.001) were statistically significant predictors of mobility aspect of HRQoL at baseline. Thirty seven subjects completed the rehabilitation sessions, data were entered in the second model (multiple R2 = 0.40, F = 4.24, P < 0.004) showing that gender (B = − 5.12, CI = − 9.86 to − 0.39, R2 = 0.23, P = 0.034), Hoehn&Yahr (B = 10.93, CI = + 3.27 to + 18.61, R2 = 0.22, P = 0.006) and PDQ-39 mobility at baseline (B = − 0.38, CI = − 0.63 to − 0.14, R2 = 0.55, P = 0.002) were statistically significant predictors of changes of the mobility aspect of HRQoL.ConclusionsBalance confidence and Freezing of Gait are associated with the mobility aspect of HRQoL. Changes in mobility domain of HRQoL (as assessed by PDQ-39) are likely to be greater in males, in people at higher stages of the disease and in people with more severe limitation in mobility domain of HRQoL (as assessed by PDQ-39) before rehabilitation. Results might be different when considering different outcomes or different measures for the same outcome (performance mobility test instead of self-report questionnaires). Further investigations are needed to better understand other components of HRQoL in addition to mobility.Trial registrationNCT02713971 registered March 8, 2016.

Health related quality of life of HIV/AIDS patients on highly active anti-retroviral therapy at a university referral hospital in Ethiopia

BackgroundHighly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life.MethodsHealth facility based cross-sectional study among 400 HIV/AIDS patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted. A pre-tested semi-structured questionnaire, which was adopted from World Health Organization Quality of life brief instrument, was used. The data were then analyzed using SPSS version 20 software for Windows.ResultsThe majority of the respondents reported to to have a good physical health (15.55). The World Health Organization clinical stage was found to be significantly associated with all the domains of health related quality of life. The current acute illness condition of the respondents, however, did not show significant association with any of the domains of health related quality of life.ConclusionsThe six domains of health related quality of life were found to be moderate. The physical health and spirituality of the patients were relatively higher than their social relationship. Sex, age, educational status, residence and marital status showed significant association with at least one domain of health related quality of life.

Salud y calidad de vida en adultos mayores de un área rural y urbana del Perú

To assess the health related quality of life in a sample of elderly population in a rural and urban Peruvian area. A cross-sectional study was performed in elderly population from four rural districts and one urban from the period October 2014 to January 2016. The association between the area of residence and five sociodemographic variables was assessed with the chi square test. Using the Wilcoxon rank sum test and assessing size effect, WHOQoL-OLD and WHOQoL-BREF domain scores and global score of the former obtained in the survey were measured and compared. Then, simple and multiple regressions were performed to adjust values to the sociodemographic differences. A total of 447 elderly people were surveyed with a mean age of 69 (DE=6,46), 207 from the rural area, most of whom worked and had less years of education.. The elderly population from the rural area had a higher quality of life in the domains "Physical", "Psychological" and "Environment" from WHOQoL-BREF and in "Sensory abilities", "Autonomy", "Past, Present and Future Activities", "Social participation" and the total score from WHOQoL-OLD, while those from the urban area only had a higher quality of life in "Intimacy". The area of residency exerts a differential effect on the distinct domains of health related quality of life in the evaluated elderly population.

Relationship between anxiety disorders and domains of health related quality of life among Nigerians with breast cancer

PurposeHealth Related Quality of life (HRQoL) is increasingly recognised as an important indicator of outcome and well-being in oncology care. We set out in this study to evaluate whether significant association exists between anxiety disorders (ADs) and HRQoL in breast cancer, such that any intervention addressing ADs would potentially improve HRQoL. MethodsA cross sectional evaluation of 200 attendees of an oncology clinic was done using designed questionnaire to gather socio-demographic and clinical data. Subsequently, the Schedule for clinical Assessment in Neuropsychiatry was used to ascertain ADs and the European Organization for Research and Treatment of Cancer QOL Questionnaire (THE EORTC QLQ-C30) Version 3 with its breast specific supplement (QLQ-BR-23) was used to profile HRQoL in participants. ResultsThe mean age of participants was 49.6(±11.2) years, and 54% of participants had stage III and IV breast cancer. Findings on EORTC QLQ-C30 following univariate analyses showed association between ADs and poorer mean scores on global health status, functional domains including physical, emotional, social, and cognitive functions (p < 0.05). On the symptom scale, those with ADs had higher symptom load including fatigue, pain, insomnia, appetite loss, diarrhoea and financial difficulties (p < 0.05). Similarly, the QLQ-BR-23 showed correlation between ADs and poorer mean scores on breast cancer specific issues like body image, future perspectives, sexual functioning, sexual enjoyment, systemic therapy side-effects, upset by hair loss and breast symptoms (p < 0.05). Findings after controlling for age, treatment, cancer duration, recurrence and stage showed the same pattern of relationship between ADs and HRQoL; however, the global health status, cognition, sexual functioning, and higher symptom load with respect to appetite loss and financial difficulties were not independently related with ADs. ConclusionsScaling up of oncological services, supportive care and targeted psychosocial interventions are indicated for optimal outcome of breast cancer. Longitudinal research with focus on the complex relationship between HRQoL and ADs along with their modifiable determinants across the trajectories of breast cancer is warranted.

Health related quality of life and depressive symptoms among seropositive African Americans

The primary aim of this descriptive correlational study was to determine which domains of health related quality of life (HRQOL) after controlling for demographic correlates predict depressive symptoms among N=70 seropositive African American men and women on Active Antiretroviral Therapy (ART). A demographic questionnaire, the Center for Epidemiological Studies Depression Scale (CESD-D), and the SF-36 Health Related Quality of Life (HRQOL) scale were administered. The regression analyses resulted in three models. The first model indicated that emotional well-being explained 38% of the variance in depressive symptoms (P=0.000) and in model two, emotional well-being and role limitations on emotional health explained 50% of the variance (P=0.000) and in the final and best fitting model emotional well-being, role limitations on emotional health and pain explained 53% of the variance in depressive symptoms (P=0.000) respectively. The findings underscore the need to explore the impact of HRQOL on mental health, and to also screen and treat seropositive African American men and women on (ART) for depressive symptoms.