Although 30million individuals are engaged in fantasy sports games in the United States, little is known about the personality, attitudes, and intentions of fantasy sports game participants. This study (N=244) explored the role of gender, sensation seeking (SS), locus of control (LOC), and need for cognition (NFC) in predicting attitudes and intentions relative to participating in fantasy football league. A domain-specific construct (e.g., perceived football knowledge: PK) was employed as a moderator to control the potential attenuating effects of personality and related human behavior. A moderated multiple regression technique (MMR) examined the first-order and lower-order interaction effects on attitudes and behavioral intentions toward fantasy games. For males (n=123), SS, LOC, and PK were related to both attitudes and intentions toward participating and PK acted as a moderator between LOC and intentions. For females (n=121), none of the personality traits was associated with attitudes or intentions. The applied and theoretical implications of the findings are discussed along with future directions for research.