In today’s digital age, innovative artificial intelligence (AI) methodologies, notably machine learning (ML) approaches, are increasingly favored for their superior accuracy in anticipating the characteristics of cementitious composites compared to typical regression models. The main focus of current research work is to improve knowledge regarding application of one of the new ML techniques, i.e., gene expression programming (GEP), to anticipate the ultra-high-performance concrete (UHPC) properties, such as flowability, flexural strength (FS), compressive strength (CS), and porosity. In addition, the process of training a model that predicts the intended outcome values when the associated inputs are provided generates the graphical user interface (GUI). Moreover, the reported ML models that have been created for the aforementioned UHPC characteristics are simple and have limited input parameters. Therefore, the purpose of this study is to predict the UHPC characteristics while taking into account a wide range of input factors (i.e., 21) and use a GUI to assess how these parameters affect the UHPC properties. This input parameters includes the diameter of steel and polystyrene fibers (µm and mm), the length of the fibers (mm), the maximum size of the aggregate particles (mm), the type of cement, its strength class, and its compressive strength (MPa) type, the contents of steel and polystyrene fibers (%), and the amount of water (kg/m3). In addition, it includes fly ash, silica fume, slag, nano-silica, quartz powder, limestone powder, sand, coarse aggregates, and super-plasticizers, with all measurements in kg/m3. The outcomes of the current research reveal that the GEP technique is successful in accurately predicting UHPC characteristics. The obtained R2, i.e., determination coefficients, from the GEP model are 0.94, 0.95, 0.93, and 0.94 for UHPC flowability, CS, FS, and porosity, respectively. Thus, this research utilizes GEP and GUI to accurately forecast the characteristics of UHPC and to comprehend the influence of its input factors, simplifying the procedure and offering valuable instruments for the practical application of the model’s capabilities within the domain of civil engineering.