The Xigaze ophiolite in the central Yarlung Zangbo suture zone (southern Tibet) provides evidence of the tectonic processes that formed the Neotethyan Ocean between the Indian and Eurasian plates. In this study, we present zircon U Pb geochronological, mineralogical, and geochemical data for mafic rocks from the Xigaze ophiolite to determine their petrogenesis and tectonic environment. The crustal section of the Xigaze ophiolite includes mainly gabbro lenses, amphibolite dikes, dolerite sills or dikes, and basaltic lavas. The absence of a well-developed gabbroic crust and sheeted dike complexes in the ophiolite indicates slow to ultraslow-spreading conditions and a heterogeneous structure of the oceanic lithosphere, which is not atypical for layered ophiolites. Zircons from the amphibolite and dolerite dike reveal crystallization ages of 125.0 ± 1.8 Ma to 123.8 ± 1.3 Ma, respectively. Geochemically, all mafic rocks have mid-ocean ridge basalt (MORB)-like affinities with enrichment in large ion lithophile elements (LILEs, U) relative to high field strength elements (HFSEs, Nb, Ta and Ti) and light rare earth elements (LREEs). They also exhibit high εNd(t) values ranging from +8.4 to +8.8 at 206 Pb/ 204 Pb = 16.75–17.64. Moreover, chromite and clinopyroxene grains from the mafic rocks have a wide compositional spectrum and are mainly plotted in the supra-subduction zone (SSZ) fields. These features indicate that MORB-like magmatism was triggered by decompression melting of the upwelling asthenospheric mantle with minor mass transfer from the subducting slab. The Xigaze ophiolite lacks boninite, high‑magnesium andesites, island arc tholeiites, and calc-alkaline lavas, which indicates that it is incompatible with the complete Izu-Bonin-Mariana forearc sequence. Combined with previous studies, we speculate that the Xigaze ophiolite represents an ancient SSZ-type oceanic lithosphere formed in the Gangdese forearc during the Early Cretaceous, and the upper plate extension is linked to the southward retreat and rollback of the Neotethyan slab. Thus, the Xigaze and other Neotethyan SSZ ophiolites with no systematic change in composition with stratigraphic age provide new insights into the diversity of melt evolution in the forearc crust. • Amphibolite and dolerite dikes in the Xigaze ophiolite were formed during the Early Cretaceous. • The mafic rocks were derived from upwelling asthenosphere with minor slab input. • The Xigaze ophiolite originated from the Gangdese forearc setting. • The SIR model appears likely to be oversimplified for variable forearc ophiolites.