Klaus Nürnberger has provided an invaluable contribution to theology over the course of his career, and he continues to do so. His recent writings focus on a model of theology that takes seriously the truth claims made by the natural sciences. This article investigates Nürnberger’s understanding of God in the context of the science–religion conversation. It particularly focuses on how Nürnberger describes the immanence and transcendence of God. Intradisciplinary and/or interdisciplinary implications: This article provides an investigation of Klaus Nürnberger’s doctrine of God, with special reference to transcendence and immanence. It engages natural science, theology and philosophy as its conversation partners.