Keratodermas are a heterogeneous group of dermatological diseases characterized by thickening of the stratum corneum of the epidermis on the palms and soles. This article discusses the main forms of keratodermas, their hereditary characteristics, clinical manifestations, methods of diagnosis and treatment, as well as important aspects of patient monitoring. Keratoderma is divided into diffuse and focal forms, each of which has its own clinical characteristics and types of inheritance (autosomal dominant and autosomal recessive). In particular, diseases such as Unna-Thost keratoderma, Meleda disease, and Papillon — Lefèvre syndrome are mentioned. The main symptoms and morphological changes of the skin in various forms of keratoderma, as well as diagnostic methods, including clinical studies and histology, are described. Treatment of keratoderma is based on the use of retinol preparations and keratolytic agents; the need for an individual approach depending on the form of the disease is emphasized. The criterion for the effectiveness of treatment is a significant reduction in the severity of clinical manifestations. Attention is paid to side effects and complications associated with therapy, as well as the importance of consultation with specialists to prevent secondary diseases such as periodontal disease. Keratoderma is a complex disease that requires an integrated approach to diagnosis and treatment. The prognosis for patients is most often unfavorable, and complete cure is impossible. It is necessary to ensure careful monitoring of the patient's health status and evaluate the efficacy of the treatment used to reduce clinical manifestations. The text provides relevant information for dermatologists and other medical professionals involved in the diagnosis and treatment of skin diseases.
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