Sciences Division Research Articles

Increased Realism in Risk Assessment and Management of Agrochemicals for a Better Balance between Food Production and Environmental Protection

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVViewpointNEXTIncreased Realism in Risk Assessment and Management of Agrochemicals for a Better Balance between Food Production and Environmental ProtectionRobin Sur*Robin SurRegulatory Science − Environmental Safety, Bayer AG Crop Science Division, 40789 Monheim, Germany*Corresponding author: Robin Sur.More by Robin Surhttps://orcid.org/0000-0002-3403-8168, Thomas G. PreussThomas G. PreussRegulatory Science − Environmental Safety, Bayer AG Crop Science Division, 40789 Monheim, GermanyMore by Thomas G. Preuss, and Andrew C. ChappleAndrew C. ChappleRegulatory Science − Environmental Safety, Bayer AG Crop Science Division, 40789 Monheim, GermanyMore by Andrew C. ChappleCite this: ACS Agric. Sci. Technol. 2023, XXXX, XXX, XXX-XXXPublication Date (Web):June 6, 2023Publication History Received14 April 2023Accepted26 May 2023Revised24 May 2023Published online6 June 2023https://doi.org/10.1021/acsagscitech.3c00106© 2023 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (819 KB) Get e-Alerts Get e-Alerts

ACS Catalysis Science and Technology Division awards to Fabio Ribeiro and Andrew J. Medford

Two awards from the American Chemical Society Division of Catalysis Science and Technology are being announced. Fabio Ribeiro , the R. Norris and Eleanor Shreve Professor of Chemical Engineering at Purdue University, is the 2023 recipient of the Exceptional Achievements in Catalysis award, in recognition of his exceptionally meritorious, impactful, and enduring scientific and leadership contributions to the broad field of catalysis science. Andrew J. “AJ” Medford , an assistant professor of chemical and biomolecular engineering at the Georgia Institute of Technology, is the 2023 recipient of the Early Career in Catalysis award. This award recognizes independent contributions to the broad field of catalysis science that are of unusual merit and creativity in the early stages of a career.

Outlook: How I Learned to Love Machine Learning (A Personal Perspective on Machine Learning in Process Systems Engineering)

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVCommentaryNEXTOutlook: How I Learned to Love Machine Learning (A Personal Perspective on Machine Learning in Process Systems Engineering)Victor M. Zavala*Victor M. ZavalaDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, United StatesMathematics and Computer Science Division, 9700 South Cass Ave., Lemont, Illinois 60439, United States*E-mail: [email protected]More by Victor M. Zavalahttps://orcid.org/0000-0002-5744-7378Cite this: Ind. Eng. Chem. Res. 2023, XXXX, XXX, XXX-XXXPublication Date (Web):June 5, 2023Publication History Received9 May 2023Published online5 June 2023https://doi.org/10.1021/acs.iecr.3c01565© 2023 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts

ACS Catalysis Science and Technology Division awards to Fabio Ribeiro and Andrew J. Medford

ACS Catalysis Science and Technology Division awards to Fabio Ribeiro and Andrew J. Medford

Principles of biostatistics (3rd ed) Marcello Pagano, Kimberlee Gauvreau, Heather Mattie (2022). Boca Raton, FL: CRC Press

BiometricsVolume 79, Issue 2 p. 1589-1590 BOOK REVIEWS Principles of biostatistics (3rd ed) , Marcello Pagano, Kimberlee Gauvreau, Heather Mattie (2022). Boca Raton, FL: CRC Press Chuhsing Kate Hsiao, Corresponding Author Chuhsing Kate Hsiao [email protected] orcid.org/0000-0003-4905-8484 Division of Biostatistics and Data Science, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan Correspondence Chuhsing Kate Hsiao, Division of Biostatistics and Data Science, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17, Xu Zhou Road, Taipei, Taiwan. Email: [email protected]Search for more papers by this author Chuhsing Kate Hsiao, Corresponding Author Chuhsing Kate Hsiao [email protected] orcid.org/0000-0003-4905-8484 Division of Biostatistics and Data Science, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan Correspondence Chuhsing Kate Hsiao, Division of Biostatistics and Data Science, Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17, Xu Zhou Road, Taipei, Taiwan. Email: [email protected]Search for more papers by this author First published: 20 June 2023 https://doi.org/10.1111/biom.13876Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. Volume79, Issue2June 2023Pages 1589-1590 RelatedInformation

Using dapagliflozin in patients with heart failure.

At Xavier University of Louisiana's College of Pharmacy, LaKeisha Williams is a Clinical Associate Professor in the Division of Clinical and Administrative Sciences and Tori Wiley was a student when article was written. The authors have disclosed no financial relationships related to this article. Unless otherwise specified, the information in the preceding summaries applies to adults, not children. Consult the package insert for information about each drug's safety during pregnancy and breastfeeding. Also consult a pharmacist, the package insert, or a comprehensive drug reference for more details on precautions, drug interactions, and adverse reactions.

Modification of the existing maximum residue levels and setting of import tolerances for fluopyram in various crops.

In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Bayer AG Crop Science Division submitted a request to the competent national authority in Italy to modify the existing maximum residue level (MRL) for the active substance fluopyram in kiwi. Additionally, the applicants Bayer Crop Science SA and Bayer SAS Crop Science Division submitted two applications to the competent national authority in Germany to modify the MRLs for fluopyram in certain stem vegetables, seed spices, apples and soyabeans based on intended EU uses as well as to lower the existing EU MRL in pome fruits and to raise the existing EU MRL in peanuts on the basis of authorised use of fluopyram in the USA. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all the crops under assessment except for palm hearts and bamboo shoots. Adequate analytical methods for enforcement are available to control the residues of fluopyram in commodities under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short-term intake of residues resulting from the use of fluopyram according to the reported agricultural practices is unlikely to present a risk to consumer health. A long-term consumer intake concern is identified if the current MRL of 0.8 mg/kg in pome fruits is maintained and new MRLs for other commodities under consideration are supported, with apples being the highest contributing commodity to the diet for which exposure exceedances were noted. The chronic risk for consumers is unlikely if a lower MRL of 0.6 mg/kg in pome fruits proposed by the applicant is considered. Further risk manager considerations are required.

Tumor Cell EnVoys Advance the Education of Platelets

HomeCirculation ResearchVol. 132, No. 11Tumor Cell EnVoys Advance the Education of Platelets No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextTumor Cell EnVoys Advance the Education of Platelets James I. Hearn and Elizabeth E. Gardiner James I. HearnJames I. Hearn https://orcid.org/0000-0002-3988-2659 Division of Genome Sciences and Cancer, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia (J.I.H., E.E.G.). Search for more papers by this author and Elizabeth E. GardinerElizabeth E. Gardiner Correspondence to: Elizabeth Gardiner, PhD, ACRF, John Curtin School of Medical Research, Australian National University, 131 Garran Rd, Canberra, ACT 2601 Australia. Email E-mail Address: [email protected] https://orcid.org/0000-0001-9453-9688 Division of Genome Sciences and Cancer, the John Curtin School of Medical Research, The Australian National University, Canberra, Australia (J.I.H., E.E.G.). The National Platelet Research and Referral Centre (NPRC), Canberra, Australia (E.E.G.). Search for more papers by this author Originally published25 May 2023https://doi.org/10.1161/CIRCRESAHA.123.322781Circulation Research. 2023;132:1462–1464This article is a commentary on the followingMechanism of Tumor-Platelet Communications in CancerFootnotesFor Disclosures, see page 1464The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Elizabeth Gardiner, PhD, ACRF, John Curtin School of Medical Research, Australian National University, 131 Garran Rd, Canberra, ACT 2601 Australia. Email elizabeth.[email protected]edu.au

Walking the 'design-build-test-learn' cycle: flux analysis and genetic engineering reveal the pliability of plant central metabolism.

This article is a Commentary on Morley et al. (2023), 239: 1834–1851.

Study on Effective of Bacillus subtilis for Domestic Wastewater Treatment in the Royal Thai Army Chemical Department Area

Recently, wastewater has been discharged from various sources into natural water sources, causing them to be contaminated with waste. Therefore, this study concentrates on guidelines for utilizing Bacillus Subtilis for wastewater treatment in the pond in front of the Science Division, Department of Army Science, which collects wastewater from office buildings and accommodations within the Royal Thai Army Science Department and discharges it to the public canal. Therefore, water must be treated before discharge. Samples were collected from a pond in front of the Science Division and a pond in front of the Pyro building for bacterial isolation (two soil samples and two water samples). The isolated and purified bacteria were used for preliminary morphological studies. All the isolated bacteria were gram-negative bacteria with 21 endospores. Protein, starch, and lipid degradation enzymes were tested using selected foods, namely skimmed milk agar, starch agar, and Tween 80 agar, and the point inoculation technique was applied. The results revealed that the isolates KCT03, KCT04, and KCT05 could produce these three groups of enzymes. The antagonism of the isolated bacteria was tested, and it was found that the three species were not antagonistic. All three samples were classified as bacteria, and KCT03 and KCT05 were found to be Bacillus subtilis. The efficiency of microbial wastewater treatment was tested at the laboratory level, and the experiment was planned to be a completely randomized design (CRD) consisting of three experimental sets and three repetitions to measure the water quality, pH, COD, BOD, TSS, TDS, oil, and fat. It was found that KCT03 was the best wastewater treatment.

Twenty years of collaborative research to enhance community practice for cancer prevention and control.

The Cancer Prevention and Control Research Network (CPCRN) was established in 2002 to conduct applied research and undertake related activities to translate evidence into practice, with a special focus on the unmet needs of populations at higher risk of getting cancer and dying from it. A network of academic, public health and community partners, CPCRN is a thematic research network of the Prevention Research Centers Program at the Centers for Disease Control and Prevention (CDC). The National Cancer Institute's Division of Cancer Control and Population Sciences (DCCPS) has been a consistent collaborator. The CPCRN has fostered research on geographically dispersed populations through cross-institution partnerships across the network. Since its inception, the CPCRN has applied rigorous scientific methods to fill knowledge gaps in the application and implementation of evidence-based interventions, and it has developed a generation of leading investigators in the dissemination and implementation of effective public health practices. This article reflects on how CPCRN addressed national priorities, contributed to CDC's programs, emphasized health equity and impacted science over the past twenty years and potential future directions.

Recent developments in photoresists for extreme-ultraviolet lithography

This report describes recent developments and current needs in the field of high-resolution photopolymers and photomolecules briefly describing prior generation lithographic patterning materials. It subsequently concentrates on recent advances in both inorganic and polymeric materials for extreme ultraviolet (EUV) lithography. It is also part of a series of papers written in celebration of the centenary of the Polymeric Materials: Science and Engineering (PMSE) division of the American Chemical Society (ACS). PMSE has long been home to polymer chemists who have made important contributions to advances in semiconductor manufacturing as a result of PMSE's focus on polymer coatings research. While EUV lithography has been an area of research for several decades, only within the last 5 years has the combination of new light sources, EUV optics, tool advances and resist discoveries come together to transition this area from the patterning method of the future to a leading-edge manufacturing technology. (148 words).

Distribution-Free Contextual Dynamic Pricing

Contextual dynamic pricing aims to set personalized prices based on sequential interactions with customers. At each time period, a customer who is interested in purchasing a product comes to the platform. The customer’s valuation for the product is a linear function of contexts, including product and customer features, plus some random market noise. The seller does not observe the customer’s true valuation, but instead needs to learn the valuation by leveraging contextual information and historic binary purchase feedback. Existing models typically assume full or partial knowledge of the random noise distribution. In this paper, we consider contextual dynamic pricing with unknown random noise in the linear valuation model. Our distribution-free pricing policy learns both the contextual function and the market noise simultaneously. A key ingredient of our method is a novel perturbed linear bandit framework, in which a modified linear upper confidence bound algorithm is proposed to balance the exploration of market noise and the exploitation of the current knowledge for better pricing. We establish the regret upper bound and a matching lower bound of our policy in the perturbed linear bandit framework and prove a sublinear regret bound in the considered pricing problem. Finally, we demonstrate the superior performance of our policy on simulations and a real-life auto loan data set. Funding: Y. Liu and W.W. Sun acknowledge support from the National Science Foundation Division of Social and Economic Sciences [Grant NSF-SES 2217440]. Supplemental Material: The supplementary material is available at https://doi.org/10.1287/moor.2023.1369 .

121 Cross Government, Industry and Academia Knowledge Sharing Workshops on Opportunities for Advanced Materials (AM) in the UK

Abstract Key decision-making organisations such as the Organization for Economic Cooperation and Development (OECD), the International Organization for Standardization (ISO) and the European Commission (EC) have started to focus on the industrial and economic implications of advanced materials (AMs). Internationally, there is a strong push for a sustainable and circular economy in which 'safety by design', recyclability and re-use will be high on the agenda. It is important material scientists, industry, and regulators consider how to work together to support the safe use of AMs. In 2021, DEFRA, HSE Science Division, NPL, UK HSA and BSI held an online workshop with industry experts, materials scientists and regulators to create a UK knowledge sharing community on the safe exploitation of AMs. This first workshop assessed the level of interest in creating an UK AM knowledge sharing community focussing on the application of safe by design for safer adoption of AMs. The participants concluded that any definition of AM related to a novel material property may be necessary but would make it difficult to use from a practical regulatory perspective. A second event is planned for early 2023 to share views on the benefits and pitfalls of the safe commercialisation of AMs; including the societal benefits that may arise and the potential obstacles to the wider adoption of these new materials. These events are being attended by organisations developing AMs, those manufacturing and using AMs, and also health and safety experts and regulators. The poster will summarise the outcomes of the two workshops.

Combustion in a Sustainable World: From Molecules to Processes.

ADVERTISEMENT RETURN TO ISSUESpecial Issue Prefac...Special Issue PrefaceNEXTCombustion in a Sustainable World: From Molecules to ProcessesStephen J. Klippenstein*Stephen J. KlippensteinChemical Sciences and Engineering Division, Argonne National Laboratory, Lemont, Illinois 60439, United States*[email protected]More by Stephen J. Klippensteinhttps://orcid.org/0000-0001-6297-9187 and Katharina Kohse-Höinghaus*Katharina Kohse-HöinghausDepartment of Chemistry, Bielefeld University, 33615 Bielefeld, Germany*[email protected]More by Katharina Kohse-Höinghaushttps://orcid.org/0000-0002-4891-9038Cite this: J. Phys. Chem. A 2023, 127, 17, 3737–3742Publication Date (Web):May 4, 2023Publication History Received27 March 2023Published online4 May 2023Published inissue 4 May 2023https://doi.org/10.1021/acs.jpca.3c02016Copyright © Published 2023 by American Chemical SocietyRIGHTS & PERMISSIONSArticle Views755Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertscloseSUBJECTS:Aromatic compounds,Fuels,Oxidation,Pyrolysis,Redox reactions Get e-Alerts

The mature c-terminal domain of filamentous hemagglutinin is sufficient to provide protection against Bordetella pertussisin the murine nasal cavity

Abstract Bordetella pertussis is the causative agent of whooping cough. The transition from whole cell (wP) to acellular pertussis vaccines (aPs) triggered an increase in pertussis incidence despite wide-spread vaccine coverage. aPs contain protein antigens purified from B. pertussis: pertactin, fimbriae, filamentous hemagglutinin (FHA), and pertussis toxin (PT). Antibodies are critical for protection against B. pertussis, and have been demonstrated to trigger opsonization, block bacterial adhesion, and neutralize disease symptoms. Following aP-vaccination, however, antibodies target a diminished number of functional B cell epitopes as the antigens are chemically denatured during aP manufacturing. The effects of denaturation on PT are well documented, but this has not been studied for other vaccine antigens, such as FHA. Additionally, FHA is a large antigen, and most of the protein does not play a role in bacterial adhesion. To direct antibody responses toward non-denatured, functionally relevant portions of FHA we aimed to test the Mature C-terminal Domain (MCD) of FHA as vaccine antigen. Protection provided by MCD was compared to several vaccine preparations, including aP and native FHA. We observed that aP and wP vaccines lead to the induction of antibodies that recognize FHA, MCD and B. pertussis. Using a CD-1 murine model of vaccination and challenge we demonstrated that MCD is immunogenic and sufficient to decrease bacterial burden in the murine airway, providing ~85% reduction in B. pertussis present in the nasal cavity. Overall, our data supports the use of MCD as a vaccine antigen for protection against B. pertussis. Ongoing studies focus on the selection of the adjuvants and route of administration to optimize vaccine efficacy. Mariette Barbier is funded by NIH grant 5R01AI141671-04. Fredrick Damron is funded by NIH grant 5R01AI137155-04. The Vaccine Development Center Research Challenge Grant (no. HEPC.dsr.18.6) from the Division of Science and Research, WV Higher Education Policy Commission also contributed support.

Conversations with Gábor J. Székely

Gábor J. Székely was born in Budapest, Hungary on February 4, 1947. He graduated from Eötvös Loránd University (ELTE) with an M.S. degree in 1970, and a Ph.D. degree in 1971. He received his Candidate Degree from the Hungarian Academy of Sciences in 1976, and the Doctor of Science Degree (D. Sc.) from the Hungarian Academy of Sciences in 1986. Székely joined the Department of Probability Theory of ELTE in 1970. In 1989, he became the founding chair of the Department of Stochastics of the Budapest Institute of Technology (Technical University of Budapest). In 1995, he moved to the United States as a tenured full professor at Bowling Green State University (BGSU) in Bowling Green, Ohio. Before that, in 1990–1991, he was the first Lukacs Distinguished Professor at BGSU. Székely had several visiting positions, for example, at the University of Amsterdam in 1977 and at Yale University in 1989. Between 2006 and 2022, he served as a Program Director in the Statistics Program of the Division of Mathematical Sciences at the U.S. National Science Foundation. Székely has about 250 publications, including 6 books in several languages. In 1988, he received the Rollo Davidson Prize from Cambridge University, jointly with Imre Z. Ruzsa for their work on algebraic probability theory. In 2010, Székely became an Elected Fellow of the Institute of Mathematical Statistics mostly for his works dealing with physics concepts in statistics like energy statistics and distance correlation. He had the fortune to know and work with world-class mathematicians and statisticians like (in chronological order of their first meetings): P. Erdős, A. Rényi, Y. Linnik, B. de Finetti, A. N. Kolmogorov, H. Robbins, G. Pólya, L. Shepp, G. Wahba, C. R. Rao, B. Efron, P. Bickel and E. Seneta.

Development and validation of a rapid GC–MS method for seized drug screening

Controlled substances are one of the most commonly analyzed types of evidence in forensic laboratories. Persistent, high levels of case submissions in recent years have created a need for rapid screening techniques to decrease case backlogs and expedite confirmatory analyses. The most utilized technique for the analysis of seized drugs is gas chromatography mass spectrometry (GC-MS). While this approach typically takes tens of minutes, advances in the technique have enabled approximately 1 min run times with a short column and a rapid (10’s °C/s) temperature program. These advances were used in this work to develop and validate a rapid GC-MS method for screening seized drug samples. Method validation was completed to determine retention time repeatability and reproducibility, limits of detection, identification accuracy, selectivity, and carryover. Validation results showed the utility of this method for accurate and precise qualitative analyses for the screening of seized drugs across seven different drug classes. The optimized method was then applied to 15 real and mock case samples from the Maryland State Police Forensic Sciences Division. Controlled substances, cutting agents, and other diluents were identified from these samples using acceptance criteria of retention time and mass spectral comparisons currently used in casework. Using rapid GC-MS methods in casework could enable faster and more reliable presumptive testing results for the analysis of seized drug exhibits.

Forensic Science in Criminalistics in Indonesia: Development and Challenges

Since the birth of forensic science until now it has developed so rapidly. the division of forensic science is so complete that it is able to assist law enforcement in carrying out the task of disclosing criminal cases. The application of forensic science has also undergone standardization that is recognized by the international community, so that in future trials, the use of forensic science can be clearly accounted for. The use of forensic science in Indonesia is the same as following international standards using standards set by the National Accreditation Agency. So that in the end it is professional staff who are needed to manpower the needs of the use of forensic science, at least being able to prevent the perpetrators of crimes from continuing their crimes.

A Systematic Review of Inflammatory Bowel Disease Epidemiology and Health Outcomes in Sexual and Gender Minority Individuals

A Systematic Review of Inflammatory Bowel Disease Epidemiology and Health Outcomes in Sexual and Gender Minority Individuals