* Abbreviations: CVAD — : central venous access device MAGIC — : Michigan Appropriateness Guide for Intravenous Catheters miniMAGIC — : Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics PICC — : peripherally inserted central catheter At the interface of clinical practice and medical science, evidence emerges. In domains of clinical practice that lack adequate evidence, clinical decisions are guided by a combination of clinical experience, clinician intuition, and resource availability (material and personnel). Consequently, where evidence gaps exist, clinical care can feel autonomous and innovative but is often inconsistent and may generate adverse outcomes for patients who are underappreciated. For children with serious illness, clinical decisions regarding achieving and sustaining venous access predominantly occur without much evidence, resulting in more variability than predictability in selecting central venous access devices (CVADs). In this supplement, an international group of pediatric experts propose a way forward using the Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics (miniMAGIC) evidence framework,1 which used the RAND Corporation–University of California, Los Angeles Appropriateness Method. miniMAGIC … Address correspondence to Matthew M. Davis, MD, MAPP, Division of Academic General Pediatrics and Primary Care, Ann & Robert H. Lurie Children’s Hospital, 225 E Chicago Ave, Box 162, Chicago, IL 60611. E-mail: mmdavis{at}luriechildrens.org